BioCryst Pharmaceuticals Valuation Multiples

BioCryst Pharmaceuticals is valued at $2.1B as of November 2026, a 3.5x revenue multiple. In the last 12 months, BioCryst Pharmaceuticals revenue was $736M.

BioCryst Pharmaceuticals Overview

About BioCryst Pharmaceuticals

BioCryst Pharmaceuticals Inc is a biotechnology company involved mainly in the research and development of novel small-molecule drugs, to block key enzymes involved in infectious and inflammatory diseases. Biocryst's research is based on multiple scientific disciplines like biology, computer modeling, and medicinal chemistry. Its products and candidates target the following therapeutic areas: acute uncomplicated influenza; uncomplicated seasonal influenza; hereditary angioedema; filoviruses, including the Ebola and Marburg viruses; and oncology.


Founded

1991

HQ

United States

Employees

580

Financials (LTM)

Revenue: $736M
Net Income: ($447M)

EV

$2.6B

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BioCryst Pharmaceuticals Financials

BioCryst Pharmaceuticals reported last 12-month revenue of $736M.

In the same LTM period, BioCryst Pharmaceuticals generated $720M in gross profit and had net loss of ($447M).

Revenue (LTM)


BioCryst Pharmaceuticals P&L

In the most recent fiscal year, BioCryst Pharmaceuticals reported revenue of $875M and EBITDA of $337M.

BioCryst Pharmaceuticals is profitable as of last fiscal year, with gross margin of 98%, EBITDA margin of 39%, and net margin of 30%.

See analyst estimates for BioCryst Pharmaceuticals
LTMLast FY202320242025202620272028
Revenue$736M$875M$331M$451M$875M
Gross Profit$720M$856M$327M$438M$856M
Gross Margin98%98%99%97%98%
EBITDA-$337M($132M)($2M)$337M
EBITDA Margin-39%(40%)(0%)39%
EBIT Margin(51%)39%(31%)(1%)39%
Net Profit($447M)$264M($227M)($89M)$264M
Net Margin(61%)30%(68%)(20%)30%
Net Debt-$339M---

Financial data powered by Morningstar, Inc.

BioCryst Pharmaceuticals Stock Performance

BioCryst Pharmaceuticals has current market cap of $2.1B, and enterprise value of $2.6B.

Market Cap Evolution


BioCryst Pharmaceuticals' stock price is $8.24.

BioCryst Pharmaceuticals share price decreased by 2.7% in the last 30 days, and increased by 14.8% in the last year.

BioCryst Pharmaceuticals has an EPS (earnings per share) of $1.03.

See more trading valuation data for BioCryst Pharmaceuticals
EVMarket CapPrice 1DPrice 1MPrice 3MPrice 12MEPS
$2.6B$2.1B-2.7%-2.7%-15.1%14.8%$1.03

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BioCryst Pharmaceuticals Valuation Multiples

BioCryst Pharmaceuticals trades at 3.5x EV/Revenue multiple, and 7.7x EV/EBITDA.

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EV / Revenue (LTM)


BioCryst Pharmaceuticals Financial Valuation Multiples

As of November 3, 2026, BioCryst Pharmaceuticals has market cap of $2.1B and EV of $2.6B.

BioCryst Pharmaceuticals has a P/E ratio of (4.7x).

LTMLast FY202320242025202620272028
EV/Revenue3.5x3.0x7.9x5.8x3.0x
EV/EBITDA-7.7x(19.7x)n/m7.7x
EV/EBIT(7.0x)7.6x(25.1x)n/m7.6x
EV/Gross Profit3.6x3.0x8.0x5.9x3.0x
P/E(4.7x)8.0x(9.3x)(23.7x)8.0x
EV/FCF-7.6x(26.8x)(49.0x)7.6x

Multiples above and below 250x are considered non-meaningful (n/m). Valuation data powered by FactSet, Inc. and Morningstar, Inc.

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BioCryst Pharmaceuticals Margins & Growth Rates

BioCryst Pharmaceuticals decreased revenue by 19% and EBITDA by 151% in the last fiscal year.

In the most recent fiscal year, BioCryst Pharmaceuticals reported gross margin of 98%, EBITDA margin of 39%, and net margin of 30%.

See estimated margins and future growth rates for BioCryst Pharmaceuticals

BioCryst Pharmaceuticals Margins

Last FY202420252026202720282029
Gross Margin98%97%98%98%
EBITDA Margin39%(0%)39%(24%)
EBIT Margin39%(1%)39%(72%)
Net Margin30%(20%)30%(82%)
FCF Margin39%(12%)39%27%

BioCryst Pharmaceuticals Growth Rates

FY+1/FY23/2424/2525/2626/2727/2828/29
Revenue Growth(19%)36%94%(19%)
Gross Profit Growth(19%)34%95%(19%)
EBITDA Growth(151%)(99%)(17488%)(151%)
EBIT Growth(249%)(98%)(13509%)(249%)
Net Profit Growth(321%)(61%)(397%)(321%)
FCF Growth(44%)(45%)(749%)(44%)

Data powered by FactSet, Inc. and Morningstar, Inc.

BioCryst Pharmaceuticals Operational KPIs

BioCryst Pharmaceuticals' revenue per employee in the last FY averaged $1.5M, while opex per employee averaged $0.9M for the same period.

BioCryst Pharmaceuticals' Rule of 40 is (43%) (metric relevant for SaaS companies only, counted as combined revenue growth rate and EBITDA margin).

BioCryst Pharmaceuticals' Rule of X is (72%) (created by Bessemer, Rule of X is another metric to measure SaaS companies, ~1.5x stronger vs. the traditional Rule of 40, counted as revenue growth rate multiplied by 2.5 plus EBITDA margin).

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LTMLast FY202320242025202620272028
Rule of 40-(43%)---
Bessemer Rule of X-(72%)---
Revenue per Employee-$1.5M---
Opex per Employee-$0.9M---
R&D Expenses to Revenue26%19%65%39%19%
Opex to Revenue-61%131%101%61%

Data powered by FactSet, Inc. and Morningstar, Inc.

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BioCryst Pharmaceuticals Competitors

BioCryst Pharmaceuticals competitors include Palvella Therapeutics, Zymeworks, Lakefront Biotherapeutics, Vericel, Dermapharm Holding, Sinocelltech Group, Aurinia Pharmaceuticals, BioKangtai, Vera Therapeutics and Jamjoom Pharma.

Most BioCryst Pharmaceuticals public comparables operate across Biopharmaceuticals and BioTech.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
Palvella Therapeutics-($38M)--(48.2x)(23.7x)
Zymeworks$106M($82M)17.0x6.6x(22.0x)25.9x
Lakefront Biotherapeutics$1.2B$350M1.7x8.9x6.0x(14.8x)
Vericel$276M$23M7.2x6.1x88.4x22.8x
Dermapharm Holding$1.3B$351M2.5x2.4x9.1x8.5x
Sinocelltech Group$235M($45M)11.0x11.3x(56.8x)-
Aurinia Pharmaceuticals$283M$124M6.4x5.6x14.5x9.4x
BioKangtai$402M$73M4.9x4.9x26.9x22.1x

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Acquisitions by BioCryst Pharmaceuticals

BioCryst Pharmaceuticals has acquired 1 company to date.

Last acquisition by BioCryst Pharmaceuticals was on October 14th 2025. BioCryst Pharmaceuticals acquired Astria Therapeutics for $700M (EV/Revenue multiple available to Pro users).

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Latest Acquisitions by BioCryst Pharmaceuticals

Astria Therapeutics
Description
Astria Therapeutics Inc is a biopharmaceutical company engaged to bring life-changing therapies to patients and families affected by rare and niche allergic and immunological diseases. Its program, STAR-0215, is a monoclonal antibody inhibitor of plasma kallikrein in preclinical development for the treatment of hereditary angioedema. Their second product candidate is STAR-0310, a monoclonal antibody OX40 antagonist that is in preclinical development for the treatment of atopic dermatitis, or AD, an immune disorder associated with loss of skin barrier function and itching.
HQ CountryUnited States
HQ City
Cambridge
Deal Date14 Oct 2025
Valuation$700M
EV/Revenue
EV/EBITDA

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About BioCryst Pharmaceuticals

When was BioCryst Pharmaceuticals founded?BioCryst Pharmaceuticals was founded in 1991.
Where is BioCryst Pharmaceuticals headquartered?BioCryst Pharmaceuticals is headquartered in United States.
How many employees does BioCryst Pharmaceuticals have?As of today, BioCryst Pharmaceuticals has over 580 employees.
Who is the CEO of BioCryst Pharmaceuticals?BioCryst Pharmaceuticals' CEO is Charles K. Gayer.
Is BioCryst Pharmaceuticals publicly listed?Yes, BioCryst Pharmaceuticals is a public company listed on Nasdaq.
What is the stock symbol of BioCryst Pharmaceuticals?BioCryst Pharmaceuticals trades under BCRX ticker.
When did BioCryst Pharmaceuticals go public?BioCryst Pharmaceuticals went public in 1994.
Who are competitors of BioCryst Pharmaceuticals?BioCryst Pharmaceuticals main competitors include Palvella Therapeutics, Zymeworks, Lakefront Biotherapeutics, Vericel, Dermapharm Holding, Sinocelltech Group, Aurinia Pharmaceuticals, BioKangtai, Vera Therapeutics, Jamjoom Pharma.
What is the current market cap of BioCryst Pharmaceuticals?BioCryst Pharmaceuticals' current market cap is $2.1B.
What is the current revenue of BioCryst Pharmaceuticals?BioCryst Pharmaceuticals' last 12 months revenue is $736M.
What is the current revenue growth of BioCryst Pharmaceuticals?BioCryst Pharmaceuticals revenue growth (NTM/LTM) is 0%.
What is the current EV/Revenue multiple of BioCryst Pharmaceuticals?Current revenue multiple of BioCryst Pharmaceuticals is 3.5x.
Is BioCryst Pharmaceuticals profitable?No, BioCryst Pharmaceuticals is not profitable.
What is the current net income of BioCryst Pharmaceuticals?BioCryst Pharmaceuticals' last 12 months net income is ($447M).
How many companies BioCryst Pharmaceuticals has acquired to date?As of November 2026, BioCryst Pharmaceuticals has acquired 1 company.
What was the largest acquisition by BioCryst Pharmaceuticals?$700M acquisition of Astria Therapeutics on 14th October 2025 was the largest M&A BioCryst Pharmaceuticals has done to date.
What companies BioCryst Pharmaceuticals acquired?BioCryst Pharmaceuticals acquired Astria Therapeutics.
In how many companies BioCryst Pharmaceuticals has invested to date?BioCryst Pharmaceuticals hasn't invested in any companies yet (or none have been disclosed publicly).

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