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- City Therapeutics
City Therapeutics Valuation Multiples
City Therapeutics is valued at $927M as of November 2026, a 78.9x revenue multiple. In the last fiscal year, City Therapeutics revenue was $14M and City Therapeutics EBITDA was ($59M).
City Therapeutics Overview
About City Therapeutics
City Therapeutics Inc is a clinical-stage biotechnology company developing the next generation of RNA interference (RNAi) therapeutics designed to silence the expression of disease-relevant proteins. Its current pipeline is focused on indications with unmet medical need, including thromboembolic diseases, Stargardt disease type 1 (Stargardt disease), and anemia of chronic disease.
Founded
2023
HQ
Employees
N/A
Website
Financials (Last FY)
EV
$1.1B
Valuation Multiples
Start free trialCity Therapeutics Financials
City Therapeutics reported last fiscal year revenue of $14M and negative EBITDA of ($59M).
In the same fiscal year, City Therapeutics generated ($59M) in EBITDA losses and had net loss of ($59M).
City Therapeutics P&L
In the most recent fiscal year, City Therapeutics reported revenue of $14M and EBITDA of ($59M).
City Therapeutics is unprofitable as of last fiscal year, with EBITDA margin of (437%) and net margin of (431%).
Financial data powered by Morningstar, Inc.
City Therapeutics Stock Performance
City Therapeutics has current market cap of $927M, and enterprise value of $1.1B.
Market Cap Evolution
City Therapeutics' stock price is $18.42.
City Therapeutics has an EPS (earnings per share) of $-1.16.
| EV | Market Cap | Price 1D | Price 1M | Price 3M | Price 12M | EPS |
|---|---|---|---|---|---|---|
| $1.1B | $927M | 7.3% | - | - | - | $-1.16 |
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Start Free TrialCity Therapeutics Valuation Multiples
City Therapeutics trades at 78.9x EV/Revenue multiple, and (18.1x) EV/EBITDA.
City Therapeutics Financial Valuation Multiples
As of November 7, 2026, City Therapeutics has market cap of $927M and EV of $1.1B.
City Therapeutics has a P/E ratio of (15.8x).
Multiples above and below 250x are considered non-meaningful (n/m). Valuation data powered by FactSet, Inc. and Morningstar, Inc.
Verified City Therapeutics Valuation Multiples
Access all public comps and forward-looking valuation multiples like EV/Revenue in 2027, based on consensus analyst estimates. Powered by FactSet and Morningstar.


City Therapeutics Margins & Growth Rates
In the most recent fiscal year, City Therapeutics reported EBITDA margin of (437%) and net margin of (431%).
City Therapeutics Margins
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City Therapeutics Operational KPIs
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City Therapeutics Competitors
City Therapeutics competitors include Philogen, Odyssey Therapeutics, Ribolia, GuangYuYuan Chinese, Mega Lifesciences, Nxera Pharma, ORIC Pharmaceuticals, Bide Pharmatech Co, Monte Rosa Therapeutics and Inventiva.
Most City Therapeutics public comparables operate across Biopharmaceuticals, Life Sciences Tools and BioTech.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| $353M | $295M | 1.6x | 2.9x | 1.9x | 4.0x | |||
| $3M | ($151M) | 208.5x | 1400.6x | (4.1x) | (3.2x) | |||
| $22M | ($33M) | 31.1x | 10.7x | (21.3x) | (34.4x) | |||
| $205M | $23M | 4.2x | - | 38.2x | - | |||
| $422M | $82M | 1.9x | 1.9x | 10.0x | 8.3x | |||
| $187M | ($26M) | 6.1x | 4.5x | (44.0x) | 17.4x | |||
| - | ($128M) | - | - | (5.1x) | (3.8x) | |||
| $199M | $33M | 3.8x | 3.5x | 23.1x | - | |||
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City Therapeutics VC Funding History
Before going public, City Therapeutics raised $235M in total equity funding, across 2 rounds.
Last private valuation of City Therapeutics was $281M, after raising $135M in October 2024 from Fidelity, Invus, Rock Springs Capital, and 4 other investors.
City Therapeutics Funding Rounds
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Start Free TrialAbout City Therapeutics
| When was City Therapeutics founded? | City Therapeutics was founded in 2023. |
| Where is City Therapeutics headquartered? | City Therapeutics is headquartered in United States. |
| Who is the CEO of City Therapeutics? | City Therapeutics' CEO is Andrew C. Orth. |
| Is City Therapeutics publicly listed? | Yes, City Therapeutics is a public company listed on Nasdaq. |
| What is the stock symbol of City Therapeutics? | City Therapeutics trades under CTY ticker. |
| When did City Therapeutics go public? | City Therapeutics went public in 2026. |
| Who are competitors of City Therapeutics? | City Therapeutics main competitors include Philogen, Odyssey Therapeutics, Ribolia, GuangYuYuan Chinese, Mega Lifesciences, Nxera Pharma, ORIC Pharmaceuticals, Bide Pharmatech Co, Monte Rosa Therapeutics, Inventiva. |
| What is the current market cap of City Therapeutics? | City Therapeutics' current market cap is $927M. |
| What is the current revenue of City Therapeutics? | City Therapeutics' last fiscal year revenue is $14M. |
| What is the current EV/Revenue multiple of City Therapeutics? | Current revenue multiple of City Therapeutics is 78.9x. |
| Is City Therapeutics profitable? | No, City Therapeutics is not profitable. |
| How many companies City Therapeutics has acquired to date? | City Therapeutics hasn't acquired any companies yet (or none have been disclosed publicly). |
| In how many companies City Therapeutics has invested to date? | City Therapeutics hasn't invested in any companies yet (or none have been disclosed publicly). |
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