City Therapeutics Valuation Multiples

City Therapeutics is valued at $927M as of November 2026, a 78.9x revenue multiple. In the last fiscal year, City Therapeutics revenue was $14M and City Therapeutics EBITDA was ($59M).

City Therapeutics Overview

About City Therapeutics

City Therapeutics Inc is a clinical-stage biotechnology company developing the next generation of RNA interference (RNAi) therapeutics designed to silence the expression of disease-relevant proteins. Its current pipeline is focused on indications with unmet medical need, including thromboembolic diseases, Stargardt disease type 1 (Stargardt disease), and anemia of chronic disease.


Founded

2023

HQ

United States

Employees

N/A

Website

citytx.com

Financials (Last FY)

Revenue: $14M
EBITDA: ($59M)

EV

$1.1B

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City Therapeutics Financials

City Therapeutics reported last fiscal year revenue of $14M and negative EBITDA of ($59M).

In the same fiscal year, City Therapeutics generated ($59M) in EBITDA losses and had net loss of ($59M).


City Therapeutics P&L

In the most recent fiscal year, City Therapeutics reported revenue of $14M and EBITDA of ($59M).

City Therapeutics is unprofitable as of last fiscal year, with EBITDA margin of (437%) and net margin of (431%).

See analyst estimates for City Therapeutics
Last FY2025202620272028
Revenue$14M$14M
EBITDA($59M)($59M)
EBITDA Margin(437%)(437%)
EBIT Margin(442%)(442%)
Net Profit($59M)($59M)
Net Margin(431%)(431%)
Net Debt($66M)-

Financial data powered by Morningstar, Inc.

City Therapeutics Stock Performance

City Therapeutics has current market cap of $927M, and enterprise value of $1.1B.

Market Cap Evolution


City Therapeutics' stock price is $18.42.

City Therapeutics has an EPS (earnings per share) of $-1.16.

See more trading valuation data for City Therapeutics
EVMarket CapPrice 1DPrice 1MPrice 3MPrice 12MEPS
$1.1B$927M7.3%---$-1.16

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City Therapeutics Valuation Multiples

City Therapeutics trades at 78.9x EV/Revenue multiple, and (18.1x) EV/EBITDA.

See NTM and 2027E valuation multiples for City Therapeutics

City Therapeutics Financial Valuation Multiples

As of November 7, 2026, City Therapeutics has market cap of $927M and EV of $1.1B.

City Therapeutics has a P/E ratio of (15.8x).

Last FY2025202620272028
EV/Revenue78.9x78.9x
EV/EBITDA(18.1x)(18.1x)
EV/EBIT(17.9x)(17.9x)
P/E(15.8x)(15.8x)
EV/FCF(24.3x)(24.3x)

Multiples above and below 250x are considered non-meaningful (n/m). Valuation data powered by FactSet, Inc. and Morningstar, Inc.

Verified City Therapeutics Valuation Multiples

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City Therapeutics Margins & Growth Rates

In the most recent fiscal year, City Therapeutics reported EBITDA margin of (437%) and net margin of (431%).

See estimated margins and future growth rates for City Therapeutics

City Therapeutics Margins

Last FY2025202720282029
EBITDA Margin(437%)(437%)
EBIT Margin(442%)(442%)
Net Margin(431%)(431%)
FCF Margin(325%)(325%)

Data powered by FactSet, Inc. and Morningstar, Inc.

City Therapeutics Operational KPIs

Access forward-looking KPIs for City Therapeutics
Last FY2025202620272028
G&A Expenses to Revenue67%67%
R&D Expenses to Revenue431%431%
Opex to Revenue542%542%

Data powered by FactSet, Inc. and Morningstar, Inc.

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City Therapeutics Competitors

City Therapeutics competitors include Philogen, Odyssey Therapeutics, Ribolia, GuangYuYuan Chinese, Mega Lifesciences, Nxera Pharma, ORIC Pharmaceuticals, Bide Pharmatech Co, Monte Rosa Therapeutics and Inventiva.

Most City Therapeutics public comparables operate across Biopharmaceuticals, Life Sciences Tools and BioTech.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
Philogen$353M$295M1.6x2.9x1.9x4.0x
Odyssey Therapeutics$3M($151M)208.5x1400.6x(4.1x)(3.2x)
Ribolia$22M($33M)31.1x10.7x(21.3x)(34.4x)
GuangYuYuan Chinese$205M$23M4.2x-38.2x-
Mega Lifesciences$422M$82M1.9x1.9x10.0x8.3x
Nxera Pharma$187M($26M)6.1x4.5x(44.0x)17.4x
ORIC Pharmaceuticals-($128M)--(5.1x)(3.8x)
Bide Pharmatech Co$199M$33M3.8x3.5x23.1x-

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City Therapeutics VC Funding History

Before going public, City Therapeutics raised $235M in total equity funding, across 2 rounds.

Last private valuation of City Therapeutics was $281M, after raising $135M in October 2024 from Fidelity, Invus, Rock Springs Capital, and 4 other investors.


City Therapeutics Funding Rounds

DateStageInvestorsRaisedValuationRev. MultipleDeal Summary
Jun-26Series BFidelity; Casdin Capital; Invus; Rock Springs Capital; NYBC Ventures; Sofinnova Investments; Slate Path Capital; AN Ventures; Viking Global Investors; Regeneron Ventures; ARCH Venture Partners$100M-City Therapeutics completed a $99.5 million Series B financing on June 9, 2026, to advance its next-generation RNAi therapeutics platform and pipeline. New investors in the round included Viking Global Investors, Sofinnova Investments, Casdin Capital, and NYBC Ventures, alongside existing investors ARCH Venture Partners, Fidelity Management & Research Company, Invus, Slate Path Capital, Rock Springs Capital, Regeneron Ventures, and AN Ventures. The financing is intended to support continued development of City Therapeutics’ RNA interference-based medicine programs. The company is described as a biopharmaceutical company focused on next-generation RNAi therapeutics, with the round positioned as a platform and pipeline expansion event rather than a strategic acquisition or buyout. City Therapeutics is based in Cambridge, Massachusetts. The available information identifies the company as an RNAi-focused biopharmaceutical firm, but does not provide revenue, EBITDA, employee count, or deal valuation beyond the financing amount.
Oct-24Series AFidelity; Invus; Rock Springs Capital; Slate Path Capital; AN Ventures; Regeneron Ventures; ARCH Venture Partners$135M$281MCity Therapeutics is a Cambridge, MA-based biopharmaceutical company developing next-generation RNAi-based medicines through engineering small interfering RNAs (siRNAs) to address challenges like off-target effects, stability, and delivery, enabling broader therapeutic applications across multiple areas. Co-founded by RNAi pioneer John Maraganore (former Alnylam CEO, now executive chair), Ari Nowacek, Robert Nelsen (ARCH Venture Partners), and Sebastian Trousil, the company launched in October 2024 with a $135 million Series A financing led by ARCH Venture Partners. Participants included Fidelity Management & Research Company, Invus, Slate Path Capital, Rock Springs Capital, Regeneron Ventures, AN Ventures, and others. The funding supports building a pipeline of innovative RNAi therapeutics, with the lead program expected to enter clinical development by end of 2025 and the product engine targeting one to two new IND filings annually starting in 2026. Key platform innovations include novel RNAi triggers like cleavage-inducing tiny RNAs and tailored targeting ligands for improved potency, specificity, and tissue access. The post-money valuation for this Series A was $280.73 million, with a price per share of $10.03. Leadership includes CSO Tracy Zimmermann (ex-Generation Bio, Alnylam), and the board features Barry Greene (ex-Alnylam, Sage Therapeutics) and Ron Philip (Orbital Therapeutics). City Therapeutics positions itself to lead the next wave of RNAi medicines, potentially rivaling monoclonal antibodies in impact, building on Alnylam alumni expertise. A follow-on Series A-II round of $16 million occurred on May 27, 2025, bringing total funding to $181 million.

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About City Therapeutics

When was City Therapeutics founded?City Therapeutics was founded in 2023.
Where is City Therapeutics headquartered?City Therapeutics is headquartered in United States.
Who is the CEO of City Therapeutics?City Therapeutics' CEO is Andrew C. Orth.
Is City Therapeutics publicly listed?Yes, City Therapeutics is a public company listed on Nasdaq.
What is the stock symbol of City Therapeutics?City Therapeutics trades under CTY ticker.
When did City Therapeutics go public?City Therapeutics went public in 2026.
Who are competitors of City Therapeutics?City Therapeutics main competitors include Philogen, Odyssey Therapeutics, Ribolia, GuangYuYuan Chinese, Mega Lifesciences, Nxera Pharma, ORIC Pharmaceuticals, Bide Pharmatech Co, Monte Rosa Therapeutics, Inventiva.
What is the current market cap of City Therapeutics?City Therapeutics' current market cap is $927M.
What is the current revenue of City Therapeutics?City Therapeutics' last fiscal year revenue is $14M.
What is the current EV/Revenue multiple of City Therapeutics?Current revenue multiple of City Therapeutics is 78.9x.
Is City Therapeutics profitable?No, City Therapeutics is not profitable.
How many companies City Therapeutics has acquired to date?City Therapeutics hasn't acquired any companies yet (or none have been disclosed publicly).
In how many companies City Therapeutics has invested to date?City Therapeutics hasn't invested in any companies yet (or none have been disclosed publicly).

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