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- Upstream Bio
Upstream Bio Valuation Multiples
Upstream Bio is valued at $177M as of November 2026. In the last 12 months, Upstream Bio revenue was $3M and Upstream Bio EBITDA was ($170M).
Upstream Bio Overview
About Upstream Bio
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases.
Founded
2021
HQ
Employees
52
Website
Sectors
Financials (LTM)
Market Cap
$177M
Valuation Multiples
Start free trialUpstream Bio Financials
Upstream Bio reported last 12-month revenue of $3M and negative EBITDA of ($170M).
In the same LTM period, Upstream Bio generated $3M in gross profit, ($170M) in EBITDA losses, and had net loss of ($163M).
Revenue (LTM)
Upstream Bio P&L
In the most recent fiscal year, Upstream Bio reported revenue of $3M and EBITDA of ($160M).
Upstream Bio is unprofitable as of last fiscal year, with gross margin of 100%, EBITDA margin of (5613%), and net margin of (5026%).
Financial data powered by Morningstar, Inc.
Upstream Bio Stock Performance
Upstream Bio has current market cap of $177M.
Market Cap Evolution
Upstream Bio's stock price is $3.23.
Upstream Bio share price decreased by 5.3% in the last 30 days, and by 88.7% in the last year.
Upstream Bio has an EPS (earnings per share) of $-2.62.
| Market Cap | Price 1D | Price 1M | Price 3M | Price 12M | EPS |
|---|---|---|---|---|---|
| $177M | 0.0% | -5.3% | -51.2% | -88.7% | $-2.62 |
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Start Free TrialUpstream Bio Valuation Multiples
Upstream Bio Financial Valuation Multiples
As of November 8, 2026, Upstream Bio has market cap of $177M.
Upstream Bio has a P/E ratio of (1.1x).
Multiples above and below 250x are considered non-meaningful (n/m). Valuation data powered by FactSet, Inc. and Morningstar, Inc.
Verified Upstream Bio Valuation Multiples
Access all public comps and forward-looking valuation multiples like EV/Revenue in 2027, based on consensus analyst estimates. Powered by FactSet and Morningstar.


Upstream Bio Margins & Growth Rates
Upstream Bio decreased revenue by 5% but EBITDA grew by 7% in the last fiscal year.
In the most recent fiscal year, Upstream Bio reported gross margin of 100%, EBITDA margin of (5613%), and net margin of (5026%).
Upstream Bio Margins
Upstream Bio Growth Rates
Data powered by FactSet, Inc. and Morningstar, Inc.
Upstream Bio Operational KPIs
Upstream Bio's revenue per employee in the last FY averaged $0.1M, while opex per employee averaged $3.1M for the same period.
Upstream Bio's Rule of 40 is (6354%) (metric relevant for SaaS companies only, counted as combined revenue growth rate and EBITDA margin).
Upstream Bio's Rule of X is (6362%) (created by Bessemer, Rule of X is another metric to measure SaaS companies, ~1.5x stronger vs. the traditional Rule of 40, counted as revenue growth rate multiplied by 2.5 plus EBITDA margin).
Data powered by FactSet, Inc. and Morningstar, Inc.
Upstream Bio Competitors
Upstream Bio competitors include Z Squared, Whitehawk Therapeutics, Medeze Group, Mayne Pharma Group, Compugen, Alpha Cognition, PepGen, Bright Minds Biosciences, PegBio and Keros Therapeutics.
Most Upstream Bio public comparables operate across Biopharmaceuticals and BioTech.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| - | ($0K) | - | - | (2709814.8x) | - | |||
| $7M | ($27M) | 4.6x | 31.6x | (1.2x) | - | |||
| $22M | $7M | 6.0x | 5.9x | 18.0x | 18.2x | |||
| $262M | $55M | 0.6x | 0.5x | 2.7x | 6.0x | |||
| $73M | $31M | 0.8x | 3.1x | 1.9x | - | |||
| $10M | ($23M) | 13.6x | 6.0x | (6.2x) | (7.5x) | |||
| - | ($88M) | - | - | (0.8x) | - | |||
| - | ($10M) | - | - | (12.7x) | (2.5x) | |||
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Upstream Bio VC Funding History
Before going public, Upstream Bio raised $408M in total equity funding, across 3 rounds.
Last private valuation of Upstream Bio was $676M, after raising $8M in February 2023 from HBM Partners.
Upstream Bio Funding Rounds
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Start Free TrialAbout Upstream Bio
| When was Upstream Bio founded? | Upstream Bio was founded in 2021. |
| Where is Upstream Bio headquartered? | Upstream Bio is headquartered in United States. |
| How many employees does Upstream Bio have? | As of today, Upstream Bio has over 52 employees. |
| Who is the CEO of Upstream Bio? | Upstream Bio's CEO is Everett Rand Sutherland. |
| Is Upstream Bio publicly listed? | Yes, Upstream Bio is a public company listed on Nasdaq. |
| What is the stock symbol of Upstream Bio? | Upstream Bio trades under UPB ticker. |
| When did Upstream Bio go public? | Upstream Bio went public in 2024. |
| Who are competitors of Upstream Bio? | Upstream Bio main competitors include Z Squared, Whitehawk Therapeutics, Medeze Group, Mayne Pharma Group, Compugen, Alpha Cognition, PepGen, Bright Minds Biosciences, PegBio, Keros Therapeutics. |
| What is the current market cap of Upstream Bio? | Upstream Bio's current market cap is $177M. |
| What is the current revenue of Upstream Bio? | Upstream Bio's last 12 months revenue is $3M. |
| What is the current revenue growth of Upstream Bio? | Upstream Bio revenue growth (NTM/LTM) is (34%). |
| Is Upstream Bio profitable? | No, Upstream Bio is not profitable. |
| What is the current EBITDA of Upstream Bio? | Upstream Bio has negative EBITDA and is not profitable. |
| What is Upstream Bio's EBITDA margin? | Upstream Bio's last 12 months EBITDA margin is (6236%). |
| What is the current FCF of Upstream Bio? | Upstream Bio's last 12 months FCF is ($74M). |
| What is Upstream Bio's FCF margin? | Upstream Bio's last 12 months FCF margin is (2714%). |
| How many companies Upstream Bio has acquired to date? | Upstream Bio hasn't acquired any companies yet (or none have been disclosed publicly). |
| In how many companies Upstream Bio has invested to date? | Upstream Bio hasn't invested in any companies yet (or none have been disclosed publicly). |
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