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Septerna Inc is a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by a proprietary Native Complex Platform. Its industrial-scale platform aims to unlock the full potential of GPCR therapies. The group discovery and development of a pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic disease. Its pipeline includes SEP-786 (PTH1R), SEP-631 (MRGPRX2), TSHR, and GLP-1R, GIPR, GCGR.
2019
75
LTM Revenue $0.9M
LTM EBITDA -$87.0M
-$55.7M
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Septerna has a last 12-month revenue of $0.9M and a last 12-month EBITDA of -$87.0M.
In the most recent fiscal year, Septerna achieved revenue of $1.1M and an EBITDA of -$79.4M.
Septerna expects next 12-month revenue of XXX and NTM EBITDA of XXX
See Septerna valuation multiples based on analyst estimates| FY 2023 | FY 2024 | FY 2025 | LTM | NTM | |
|---|---|---|---|---|---|
| Revenue | $0.2M | $1.1M | XXX | XXX | XXX |
| Gross Profit | n/a | n/a | XXX | XXX | XXX |
| Gross Margin | NaN% | NaN% | XXX | XXX | XXX |
| EBITDA | -$44.7M | -$79.4M | XXX | XXX | XXX |
| EBITDA Margin | -29604% | -7388% | XXX | XXX | XXX |
| Net Profit | -$27.7M | $4.2M | XXX | XXX | XXX |
| Net Margin | -18328% | 389% | XXX | XXX | XXX |
| Net Debt | n/a | n/a | XXX | XXX | XXX |
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As of April 15, 2025, Septerna's stock price is $6.
Septerna has current market cap of $270M, and EV of -$55.7M.
See Septerna trading valuation data| EV | Market Cap | Price 1D | Price 1M | Price 3M | Price 12M | EPS |
|---|---|---|---|---|---|---|
| -$55.7M | $270M | XXX | XXX | XXX | XXX | $-5.71 |
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Sign UpAs of April 15, 2025, Septerna has market cap of $270M and EV of -$55.7M.
Septerna's trades at -64.3x LTM EV/Revenue multiple, and 0.6x LTM EBITDA.
Analysts estimate Septerna's 2025E EV/Revenue multiple at XXX and 2025E EV/EBITDA multiple at XXX
See valuation multiples for Septerna and 10K+ public comps| FY 2024 | FY 2025E | FY 2026E | FY 2027E | |
|---|---|---|---|---|
| EV | -$55.7M | XXX | XXX | XXX |
| EV/Revenue | -51.8x | XXX | XXX | XXX |
| EV/EBITDA | 0.7x | XXX | XXX | XXX |
| P/E | -3.8x | XXX | XXX | XXX |
| P/E/Growth | n/a | XXX | XXX | XXX |
| EV/FCF | 0.8x | XXX | XXX | XXX |
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Access all public comps and forward-looking valuation multiples like EV/Revenue in 2025, based on equity research analyst estimates.
Sign UpSepterna's NTM/LTM revenue growth is -71%
Septerna's revenue per employee for the last fiscal year averaged $14K, while opex per employee averaged $1.1M for the same period.
Over next 12 months, Septerna's ratio of sales and marketing spend to revenue is estimated to be XXX , while its R&D spend to revenue to be XXX .
Analysts estimate Septerna's 2025E EV/Revenue multiple at XXX and 2025E EV/EBITDA multiple at XXX
See operational valuation multiples for Septerna and other 10K+ public comps| FY 2024 | NTM | FY 2025E | FY 2026E | FY 2027E | |
|---|---|---|---|---|---|
| Revenue Growth | 612% | XXX | XXX | XXX | XXX |
| EBITDA Margin | -7388% | XXX | XXX | XXX | XXX |
| EBITDA Growth | 78% | XXX | XXX | XXX | XXX |
| Rule of 40 (SaaS-only) | -7459% | XXX | XXX | XXX | XXX |
| Revenue per Employee | $14K | XXX | XXX | XXX | XXX |
| Opex per Employee | $1.1M | XXX | XXX | XXX | XXX |
| S&M Expenses to Revenue | n/a | XXX | XXX | XXX | XXX |
| G&A Expenses to Revenue | 1541% | XXX | XXX | XXX | XXX |
| R&D Expenses to Revenue | 6078% | XXX | XXX | XXX | XXX |
| Opex to Revenue | 7618% | XXX | XXX | XXX | XXX |
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Benchmark public comps and private revenue and EBITDA valuation multiples across GRC software, cloud infrastructure, DevOps, online marketplaces and so much more!
| EV/Revenue | EV/EBITDA | |||||
|---|---|---|---|---|---|---|
| 2025E | 2026E | 2027E | 2025E | 2026E | 2027E | |
| Julphar | XXX | XXX | XXX | XXX | XXX | XXX |
| Galapagos | XXX | XXX | XXX | XXX | XXX | XXX |
| Pharming | XXX | XXX | XXX | XXX | XXX | XXX |
| Vivoryon Therapeutics | XXX | XXX | XXX | XXX | XXX | XXX |
| Armata Pharmaceuticals | XXX | XXX | XXX | XXX | XXX | XXX |
| XXXXXXXX | XXX | XXX | XXX | XXX | XXX | XXX |
| XXXXXXXX | XXX | XXX | XXX | XXX | XXX | XXX |
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Septerna acquired XXX companies to date.
Last acquisition by Septerna was XXXXXXXX, XXXXX XXXXX XXXXXX . Septerna acquired XXXXXXXX for XXX (EV/Revenue multiple of XXX ).
See M&A valuation multiples| Acquired Company | EV | EV/Revenue | EV/EBITDA |
|---|---|---|---|
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
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Sign Up| When was Septerna founded? | Septerna was founded in 2019. |
| Where is Septerna headquartered? | Septerna is headquartered in United States of America. |
| How many employees does Septerna have? | As of today, Septerna has 75 employees. |
| Who is the CEO of Septerna? | Septerna's CEO is Dr. Jeffrey T. Finer, M.D.,PhD. |
| Is Septerna publicy listed? | Yes, Septerna is a public company listed on NAS. |
| What is the stock symbol of Septerna? | Septerna trades under SEPN ticker. |
| When did Septerna go public? | Septerna went public in 2024. |
| Who are competitors of Septerna? | Similar companies to Septerna include e.g. Julphar, Galapagos, Pharming, Vivoryon Therapeutics. |
| What is the current market cap of Septerna? | Septerna's current market cap is $270M |
| What is the current revenue of Septerna? | Septerna's last 12-month revenue is $0.9M. |
| What is the current EBITDA of Septerna? | Septerna's last 12-month EBITDA is -$87.0M. |
| What is the current EV/Revenue multiple of Septerna? | Current revenue multiple of Septerna is -64.3x. |
| What is the current EV/EBITDA multiple of Septerna? | Current EBITDA multiple of Septerna is 0.6x. |
| What is the current revenue growth of Septerna? | Septerna revenue growth between 2023 and 2024 was 612%. |
| Is Septerna profitable? | Yes, Septerna is EBITDA-positive (as of the last 12 months). |
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