Zenflow Funding, Investors & Competitors

Zenflow has raised $132M across 5 funding rounds, most recently a $52M Series D in October 2026.

Last Zenflow funding round

$52M

Series D · Oct 2026

Cumulative funding Zenflow raised

$132M

across 5 funding rounds

Key investors in Zenflow

  • F-Prime
  • UpHonest Capital
  • Propel(X)
  • SV Tech Ventures
  • Invus Opportunities
  • MedTech Venture Partners
  • Cook Medical
  • Y Combinator

Zenflow Overview

About Zenflow

Zenflow is a medical device company developing minimally invasive treatments for benign prostatic hyperplasia. The BPH treatment uses a chip-implanted implant delivered via cystoscope, FDA-approved in 2023. Redwood City, California-headquartered since 2014, Zenflow conducts trials at Mayo Clinic.


Founded

2014

HQ

United StatesSan Francisco, CA

Status

Privately held

Customer focus

B2B

Revenue model

Product sales

Zenflow Funding History

Zenflow has raised a total of $132M across 5 funding rounds.

Zenflow's first fundraising round was a $100K seed round in March 2015. The most recent completed round was a $52M Series D in October 2026.

Zenflow funding rounds

Zenflow funding rounds
DateStageInvestorsRaisedDeal Summary
Oct 2026Series DCook Medical (lead)$52MCook Medical led an oversubscribed USD 52 million Series D financing round for Zenflow in October 2026. Zenflow is a medical device company developing minimally invasive treatment solutions for benign prostatic hyperplasia (BPH). Founded in 2014 and based in San Francisco, California, the company developed the Zenflow Spring, an FDA-approved implant and delivery system for treating enlarged prostate. The device provides symptom relief without the side effects associated with medications or the invasiveness of traditional surgery. Zenflow's approach allows for faster recovery, maintains sexual function, and is reversible. Cook Medical committed to an exclusive distribution agreement positioning itself as a key commercial partner, leveraging its sales infrastructure and deep relationships with urologists. The round included participation from ClavystBio, F-Prime, Invus Opportunities, and MedTech Venture Partners.
Nov 2024Series CCook Medical (lead); MedTech Venture Partners; F-Prime; Invus Opportunities$24MZenflow, Inc. is a medical device company based in South San Francisco, California, developing the Spring® System, a minimally invasive treatment for urinary obstruction caused by benign prostatic hyperplasia (BPH), an enlarged prostate condition affecting over 40 million patients in the U.S. The Spring System uses a small spring-like coil to gently prop open the urethra, restoring normal function while preserving natural anatomy, avoiding tissue removal, ablation, or piercing, and offering reversibility at the patient's and physician's discretion. On November 18, 2024, Zenflow closed a $24 million Series C financing round led by new investor Cook Medical, with participation from existing investors Invus Opportunities, F-Prime Capital, Medical Technology Venture Partners, and others. Cook Medical described the investment as strategic, aligning with their focus on minimally invasive technologies that restore flow in urology. Cook Medical, family-owned since 1963, emphasized their commitment to physician-developed technologies eliminating open surgery needs. The company has over two dozen employees and is approximately 10 years old. Proceeds from the round will support Zenflow's Pre-Market Approval (PMA) submission to the FDA and preparations for commercialization upon approval. CEO Shreya Mehta highlighted the company's clinical evidence foundation positioning it for PMA advancement, with Cook Medical's expertise aiding commercialization efforts. Wilson Sonsini advised the existing investors on the transaction.
Apr 2021Series BInvus Opportunities (lead); Propel(X); CloudStone Capital; Astia; SV Tech Ventures; F-Prime; Golden Seeds$24MZenflow, Inc. is a medical device company developing the Spring® System, a minimally invasive treatment for benign prostatic hyperplasia (BPH), the enlargement of the prostate gland that causes urinary obstruction symptoms in millions of men. The Spring System uses a small spring-like coil to gently prop open the urethra, restoring normal function while preserving natural anatomy. Over 40 million patients suffer from BPH in the United States alone, and approximately 400 million men worldwide experience this condition. In June 2021, Zenflow closed a $24 million Series B financing round led by Invus Opportunities with participation from F-Prime Capital, Medical Technology Venture Partners, Golden Seeds, Astia Angels, CloudStone Capital, SV Tech Ventures, and others. The proceeds were designated to support the company's pivotal clinical trial and advance FDA clearance of the Spring System. At the time of the Series B round, the company had conducted clinical studies treating approximately 300 patients total (200 in the pivotal study and 100 in prior studies), generating what leadership described as positive and rigorous clinical evidence. Following the Series B, the company appointed Susan Stimson as President to lead commercialization efforts. By November 2024, Zenflow announced a Series C round of $24 million that included new investor Cook Medical, with proceeds supporting Pre-Market Approval (PMA) submission and commercial preparation for FDA approval.
Feb 2018Series AF-Prime (lead); Invus (lead); MedTech Venture Partners (lead); Newton Fund; Propel(X); Shangbay Capital; SV Tech Ventures; StartX (Stanford-StartX Fund); UpHonest Capital$31MZenflow, Inc. is a medical device company based in the San Francisco Bay Area, developing the Spring System, a minimally invasive implant for treating benign prostatic hyperplasia (BPH), which causes urinary obstruction in enlarged prostates affecting nearly 400 million men worldwide. Founded in 2014 by Nick Damiano and Shreya Mehta through Stanford Biodesign, the company was one of the first medical device startups funded by Y Combinator and supported by StartX and the Rosenman Institute at QB3. On February 7, 2018, Zenflow closed a $31.4 million Series A equity financing round led by Invus Opportunities, F-Prime Capital Partners, and Medical Technology Venture Partners, with participation from other investors including Stanford-StartX Fund, SV Tech Ventures, ShangBay Capital, Propel(X), Newton Fund, and UpHonest Capital. The funds were allocated to additional clinical studies in the UK, Australia, New Zealand, and Mexico, pursuing FDA Investigational Device Exemption for a U.S. pivotal trial, and preparing for commercial launch. Zenflow had previously raised $5.2 million in seed funding between 2015 and 2017, mostly from angels, and received grants from NIH and NSF. Early traction included the 2016 ZEST Study, a first-in-human trial in New Zealand with all patients followed beyond 12 months, showing promising safety and lasting symptom relief. The Spring System aims to offer a simple, physician-led procedure with fast recovery and minimal side effects compared to existing BPH treatments. Zenflow continued raising capital post-Series A, including a Series B of $24 million and a Series C of $24 million in 2024 from similar investors like Invus, F-Prime, and MedTech Venture Partners, plus new backers like Cook Medical, bringing total funding to over $87 million across multiple rounds.
Mar 2015SeedY Combinator; SP Investment Fund; UpHonest Capital$100K-

Who has invested in Zenflow?

16 investors have backed Zenflow across its funding rounds, including F-Prime, UpHonest Capital, Propel(X), SV Tech Ventures, Invus Opportunities and MedTech Venture Partners.

Lead investors include Cook Medical, Invus Opportunities, F-Prime, Invus and MedTech Venture Partners.


Zenflow Investors

Investors in Zenflow by funding rounds participated
InvestorHQRoundsRoleFirst check
F-PrimeUnited StatesUnited States3LeadFeb 2018
Propel(X)United StatesSan Francisco, CA2ParticipantFeb 2018
Cook MedicalUnited StatesBloomington, IL2LeadNov 2024
MedTech Venture PartnersUnited StatesSan Francisco, CA2LeadFeb 2018
SV Tech VenturesUnited StatesSan Francisco, CA2ParticipantFeb 2018
Invus OpportunitiesUnited StatesNew York City, NY2LeadApr 2021
UpHonest CapitalUnited StatesSan Francisco, CA2ParticipantMar 2015
Newton FundUnited StatesSan Francisco, CA1ParticipantFeb 2018
Y CombinatorUnited StatesSan Francisco, CA1ParticipantMar 2015
InvusUnited StatesNew York City, NY1LeadFeb 2018
CloudStone CapitalChinaBeijing1ParticipantApr 2021
Shangbay CapitalUnited StatesSan Francisco, CA1ParticipantFeb 2018
AstiaUnited StatesSan Francisco, CA1ParticipantApr 2021

This data is available for Pro users. Sign up to see all 16 Zenflow investors.

Start Free Trial

Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples

Sign up to see data on 350K+ funding rounds and disclosed revenue and EBITDA valuation multiples, from seed, through growth stage, to pre-IPO.

Start Free Trial

Zenflow Competitors

Zenflow competitors include listed companies like Johnson & Johnson, Roche, Thermo Fisher Scientific and Danaher, and private ones like Biosplice Therapeutics and Neuralink.

Public and private companies comparable to Zenflow
CompanyHQStatusRevenueEBITDAValuationRevenue Multiple
Johnson & JohnsonUnited StatesUnited StatesPublicly listed$94B$40B$665B6.9x
RocheSwitzerlandSwitzerlandPublicly listed$78B$26B$382B5.3x
Thermo Fisher ScientificUnited StatesUnited StatesPublicly listed$45B$11B$257B6.2x
DanaherUnited StatesUnited StatesPublicly listed$25B$6.9B$162B7.0x
Biosplice TherapeuticsUnited StatesSan Diego, CAPrivate--$12B-
NeuralinkUnited StatesUnited StatesPrivate--$9B-

Zenflow Public Comps

Zenflow is still privately-owned, but its public comps include Samsung, Johnson & Johnson, Roche, Thermo Fisher Scientific, Siemens, Abbott, Danaher, Intuitive Surgical, Medtronic and Stryker.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
Samsung$247B$68B3.1x1.6x11.3x2.7x
Johnson & Johnson$94B$40B7.4x6.9x17.3x18.8x
Roche$78B$26B5.3x5.3x15.7x13.3x
Thermo Fisher Scientific$45B$11B6.6x6.2x27.9x24.0x
Siemens$88B$15B3.0x2.8x18.0x15.5x
Abbott$44B$12B4.9x4.4x18.5x16.8x
Danaher$25B$6.9B7.4x7.0x26.4x22.0x
Intuitive Surgical$10B$3.6B15.2x13.1x43.0x28.5x

This data is available for Pro users. Sign up to see all Zenflow competitors and their valuation data.

Start Free Trial

Common questions about Zenflow

When was Zenflow founded?Zenflow was founded in 2014.
Where is Zenflow headquartered?Zenflow is headquartered in San Francisco, CA, United States.
Is Zenflow publicly listed?No, Zenflow is a private, VC-backed company.
How much funding has Zenflow raised?Zenflow has raised $132M across 5 funding rounds.
What was Zenflow's last funding round?Zenflow's last funding round was a $52M Series D in October 2026, led by Cook Medical.
Who are Zenflow's investors?Zenflow's investors include F-Prime, Propel(X), Cook Medical, MedTech Venture Partners, SV Tech Ventures, Invus Opportunities, UpHonest Capital, Newton Fund, Y Combinator, Invus and 6 others.
Which companies are comparable to Zenflow?Companies comparable to Zenflow include Johnson & Johnson, Roche, Thermo Fisher Scientific, Danaher, Biosplice Therapeutics and Neuralink.

See companies similar to Zenflow

Start Your
Free Trial Today

Try Multiples for free for 3 days. Got questions or need a demo? Schedule a call with us below.

Start Trial