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- Biosplice Therapeutics
Biosplice Therapeutics Valuation, Funding & Investors
Biosplice Therapeutics is valued at $12B as of August 2018.
Last Biosplice Therapeutics valuation
$12B
Series B · Aug 2018
Last Biosplice Therapeutics funding round
$120M
Undisclosed stage · Apr 2021
Cumulative funding Biosplice Therapeutics raised
$778M
across 3 funding rounds
Key investors in Biosplice Therapeutics
Vickers Venture Partners
Starling Group
Sands Capital Ventures
aMoon Fund
Eventide
Polar Light Ventures
About Biosplice Therapeutics
Biosplice Therapeutics is a clinical-stage biotechnology firm headquartered in San Diego, California. The company develops small-molecule modulators of splicing factors to treat degenerative diseases, fibrosis, and cancers, with lead candidates in phase II trials for osteoarthritis and dry age-related macular degeneration.
Founded
2008
HQ
Website
Status
Privately held
Customer focus
B2B
Revenue model
Product sales
Valuation
$12B (Aug 2018)
Biosplice Therapeutics Valuation
Biosplice Therapeutics is currently valued at $12B, based on its Series B in August 2018.
The $438M round was led by Starling Group and Vickers Venture Partners, with participation from Swicorp.
Biosplice Therapeutics' valuation has grown 2.0x from $6B at its Series A in September 2013 to $12B in August 2018, across 2 priced rounds.
Biosplice Therapeutics valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Aug 2018 | Series B | $12B |
| Sep 2013 | Series A | $6B |
Biosplice Therapeutics Funding History
Biosplice Therapeutics has raised a total of $778M across 3 funding rounds.
Biosplice Therapeutics' first fundraising round was a $220M Series A in September 2013. The most recent completed round was a $120M undisclosed-stage round in April 2021.
Biosplice Therapeutics funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Apr 2021 | Undisclosed stage | aMoon Fund (lead); Eventide (lead); Verition Fund Management; Sands Capital Ventures; Symbiosis Group | $120M | - | Biosplice Therapeutics, a clinical-stage biotechnology company based in San Diego, develops small-molecule therapeutics targeting alternative pre-mRNA splicing to treat diseases including osteoarthritis, cancer, and neurological disorders. Its platform stems from discoveries in Wnt pathway modulation and CLK/DYRK kinases, enabling regulation of tissue-specific mRNA splice sites. Key assets include lorecivivint in Phase 3 for osteoarthritis and cirtuvivint for oncology. On April 15, 2021, Biosplice closed a $120 million equity financing round, described as Series B in some sources, with new investors including aMoon Fund, Eventide Asset Management, Sands Capital, Symbiosis Group, and Verition Fund Management. Proceeds were allocated to advance clinical development of lorecivivint, its Phase 3 osteoarthritis therapy, and expand oncology and neurology programs. The company had previously raised significant capital, including $438 million in 2018 (as Samumed) at a $12 billion valuation, contributing to total funding exceeding $561 million across six rounds by 2021. Biosplice licensed lorecivivint to partners like Haisco Pharmaceutical (up to $140 million for China rights) and Samil Pharmaceutical ($70 million for Korea). It later discontinued a baldness program (dalosirvat) and reduced staff by 41 in late 2021 amid pipeline focus on osteoarthritis and oncology. |
| Aug 2018 | Series B | Starling Group (lead); Vickers Venture Partners (lead); Swicorp | $438M | $12B | Biosplice Therapeutics, formerly known as Samumed, is a San Diego-based biotech company developing small-molecule therapeutics that modulate alternative pre-mRNA splicing, with a focus on CLK/DYRK kinases and Wnt pathway biology for applications in oncology, osteoarthritis, and other areas. The company raised $438 million in a major private financing round in 2018, which was the second largest that year behind Moderna, backed by investors including Starling Group, Vickers Venture Partners, and Swicorp (Ingka Group, Ikea's venture arm). This round came after operating undercover from 2008 to 2016. Sources mention a $12B valuation associated with 2018 and specifically $12.44B as of 8/6/2018, but do not confirm it as post-money for this exact round. Post-2018, Biosplice secured an additional $120 million in April 2021 and has advanced key assets like lorecivivint, a topical CLK inhibitor for knee osteoarthritis that completed phase 3 trials in 2021, with ongoing long-term studies. The company licensed lorecivivint to Haisco Pharmaceutical for up to $140 million in China (September 2021) and to Samil Pharmaceutical for $70 million in Korea (April 2021). It also has an oncology candidate, cirtuvivint (SM08502), a DYRK1A inhibitor in phase 1 trials, and entered a pre-clinical collaboration with Novo Nordisk for DYRK inhibitors in diabetes. By late 2021, Biosplice faced challenges, announcing layoffs of 41 employees (nearly half from clinical operations) effective February 2022, and dropping its male pattern baldness program, amid questions over its high valuation trajectory. Total funding across rounds reached approximately $884 million, with employee count around 45 and estimated current valuation listed at $12B in some trackers, though recent developments suggest a reevaluation. |
| Sep 2013 | Series A | Polar Light Ventures; Starling Group; Vickers Venture Partners | $220M | $6B | - |
Who has invested in Biosplice Therapeutics?
9 investors have backed Biosplice Therapeutics across its funding rounds, including Vickers Venture Partners, Starling Group, Sands Capital Ventures, aMoon Fund, Eventide and Polar Light Ventures.
Lead investors include aMoon Fund, Eventide, Starling Group and Vickers Venture Partners.
Biosplice Therapeutics Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 2 | Lead | Sep 2013 | ||
| 2 | Lead | Sep 2013 | ||
| 1 | Participant | Aug 2018 | ||
| 1 | Lead | Apr 2021 | ||
| 1 | Participant | Apr 2021 | ||
| 1 | Lead | Apr 2021 | ||
| 1 | Participant | Apr 2021 | ||
This data is available for Pro users. Sign up to see all 9 Biosplice Therapeutics investors. Start Free Trial | ||||
Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
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Start Free TrialBiosplice Therapeutics Competitors
Biosplice Therapeutics competitors include listed companies like Baxter International and Zydus Lifesciences, and private ones like Biomat USA, ArsenalBio, BioRay Pharmaceuticals and Rakuten Medical.
| Company | HQ | Status | Revenue | EBITDA | Valuation | Revenue Multiple |
|---|---|---|---|---|---|---|
| Publicly listed | $11B | $714M | $12B | 1.7x | ||
| Publicly listed | $2.8B | $831M | $12B | 4.2x | ||
| Private | - | - | $4.2B | - | ||
| Private | - | - | $1.9B | - | ||
| Private | $131M | - | $1.9B | 14.5x | ||
| Private | - | - | $1.7B | - |
Biosplice Therapeutics Public Comps
Biosplice Therapeutics is still privately-owned, but its public comps include Baxter International, Zydus Lifesciences, Fresenius Medical Care, Smith & Nephew, United Imaging, Wuxi XDC, Madrigal Pharmaceuticals, Corcept Therapeutics, Cipla and Recordati.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| $11B | $714M | 1.7x | 1.7x | 27.2x | 8.5x | |||
| $2.8B | $831M | 4.6x | 4.2x | 15.5x | 16.7x | |||
| $23B | $3.8B | 1.1x | 1.1x | 6.4x | 6.0x | |||
| $6.2B | $1.5B | 2.4x | 2.3x | 9.8x | 8.9x | |||
| $2.1B | $367M | 5.5x | 4.8x | 30.7x | 26.9x | |||
| $886M | $256M | 13.1x | 10.4x | 45.4x | 33.3x | |||
| $958M | ($302M) | 12.4x | 8.7x | (39.3x) | - | |||
| $761M | $47M | 15.9x | 12.0x | 259.2x | 59.8x | |||
This data is available for Pro users. Sign up to see all Biosplice Therapeutics competitors and their valuation data. Start Free Trial | ||||||||
Common questions about Biosplice Therapeutics
| When was Biosplice Therapeutics founded? | Biosplice Therapeutics was founded in 2008. |
| Where is Biosplice Therapeutics headquartered? | Biosplice Therapeutics is headquartered in San Diego, CA, United States. |
| Is Biosplice Therapeutics publicly listed? | No, Biosplice Therapeutics is a private, VC-backed company. |
| What is Biosplice Therapeutics' valuation? | Biosplice Therapeutics was last valued at $12B in its Series B in August 2018. |
| How much funding has Biosplice Therapeutics raised? | Biosplice Therapeutics has raised $778M across 3 funding rounds. |
| What was Biosplice Therapeutics' last funding round? | Biosplice Therapeutics' last funding round was a $120M undisclosed-stage round in April 2021, led by aMoon Fund and Eventide. |
| Who are Biosplice Therapeutics' investors? | Biosplice Therapeutics' investors include Starling Group, Vickers Venture Partners, Swicorp, Eventide, Verition Fund Management, aMoon Fund, Sands Capital Ventures, Polar Light Ventures and Symbiosis Group. |
| Which companies are comparable to Biosplice Therapeutics? | Companies comparable to Biosplice Therapeutics include Baxter International, Zydus Lifesciences, Biomat USA, ArsenalBio, BioRay Pharmaceuticals and Rakuten Medical. |
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