Biosplice Therapeutics Valuation, Funding & Investors

Biosplice Therapeutics is valued at $12B as of August 2018.

Last Biosplice Therapeutics valuation

$12B

Series B · Aug 2018

Last Biosplice Therapeutics funding round

$120M

Undisclosed stage · Apr 2021

Cumulative funding Biosplice Therapeutics raised

$778M

across 3 funding rounds

Key investors in Biosplice Therapeutics

  • Vickers Venture Partners
  • Starling Group
  • Sands Capital Ventures
  • aMoon Fund
  • Eventide
  • Polar Light Ventures

Biosplice Therapeutics Overview

About Biosplice Therapeutics

Biosplice Therapeutics is a clinical-stage biotechnology firm headquartered in San Diego, California. The company develops small-molecule modulators of splicing factors to treat degenerative diseases, fibrosis, and cancers, with lead candidates in phase II trials for osteoarthritis and dry age-related macular degeneration.


Founded

2008

HQ

United StatesSan Diego, CA

Status

Privately held

Customer focus

B2B

Revenue model

Product sales

Valuation

$12B (Aug 2018)

Biosplice Therapeutics Valuation

Biosplice Therapeutics is currently valued at $12B, based on its Series B in August 2018.

The $438M round was led by Starling Group and Vickers Venture Partners, with participation from Swicorp.

Biosplice Therapeutics' valuation has grown 2.0x from $6B at its Series A in September 2013 to $12B in August 2018, across 2 priced rounds.

Biosplice Therapeutics valuation by funding round

Biosplice Therapeutics valuation by funding round
DateStageValuation
Aug 2018Series B$12B
Sep 2013Series A$6B

Biosplice Therapeutics Funding History

Biosplice Therapeutics has raised a total of $778M across 3 funding rounds.

Biosplice Therapeutics' first fundraising round was a $220M Series A in September 2013. The most recent completed round was a $120M undisclosed-stage round in April 2021.

Biosplice Therapeutics funding rounds

Biosplice Therapeutics funding rounds
DateStageInvestorsRaisedValuationDeal Summary
Apr 2021Undisclosed stageaMoon Fund (lead); Eventide (lead); Verition Fund Management; Sands Capital Ventures; Symbiosis Group$120M-Biosplice Therapeutics, a clinical-stage biotechnology company based in San Diego, develops small-molecule therapeutics targeting alternative pre-mRNA splicing to treat diseases including osteoarthritis, cancer, and neurological disorders. Its platform stems from discoveries in Wnt pathway modulation and CLK/DYRK kinases, enabling regulation of tissue-specific mRNA splice sites. Key assets include lorecivivint in Phase 3 for osteoarthritis and cirtuvivint for oncology. On April 15, 2021, Biosplice closed a $120 million equity financing round, described as Series B in some sources, with new investors including aMoon Fund, Eventide Asset Management, Sands Capital, Symbiosis Group, and Verition Fund Management. Proceeds were allocated to advance clinical development of lorecivivint, its Phase 3 osteoarthritis therapy, and expand oncology and neurology programs. The company had previously raised significant capital, including $438 million in 2018 (as Samumed) at a $12 billion valuation, contributing to total funding exceeding $561 million across six rounds by 2021. Biosplice licensed lorecivivint to partners like Haisco Pharmaceutical (up to $140 million for China rights) and Samil Pharmaceutical ($70 million for Korea). It later discontinued a baldness program (dalosirvat) and reduced staff by 41 in late 2021 amid pipeline focus on osteoarthritis and oncology.
Aug 2018Series BStarling Group (lead); Vickers Venture Partners (lead); Swicorp$438M$12BBiosplice Therapeutics, formerly known as Samumed, is a San Diego-based biotech company developing small-molecule therapeutics that modulate alternative pre-mRNA splicing, with a focus on CLK/DYRK kinases and Wnt pathway biology for applications in oncology, osteoarthritis, and other areas. The company raised $438 million in a major private financing round in 2018, which was the second largest that year behind Moderna, backed by investors including Starling Group, Vickers Venture Partners, and Swicorp (Ingka Group, Ikea's venture arm). This round came after operating undercover from 2008 to 2016. Sources mention a $12B valuation associated with 2018 and specifically $12.44B as of 8/6/2018, but do not confirm it as post-money for this exact round. Post-2018, Biosplice secured an additional $120 million in April 2021 and has advanced key assets like lorecivivint, a topical CLK inhibitor for knee osteoarthritis that completed phase 3 trials in 2021, with ongoing long-term studies. The company licensed lorecivivint to Haisco Pharmaceutical for up to $140 million in China (September 2021) and to Samil Pharmaceutical for $70 million in Korea (April 2021). It also has an oncology candidate, cirtuvivint (SM08502), a DYRK1A inhibitor in phase 1 trials, and entered a pre-clinical collaboration with Novo Nordisk for DYRK inhibitors in diabetes. By late 2021, Biosplice faced challenges, announcing layoffs of 41 employees (nearly half from clinical operations) effective February 2022, and dropping its male pattern baldness program, amid questions over its high valuation trajectory. Total funding across rounds reached approximately $884 million, with employee count around 45 and estimated current valuation listed at $12B in some trackers, though recent developments suggest a reevaluation.
Sep 2013Series APolar Light Ventures; Starling Group; Vickers Venture Partners$220M$6B-

Who has invested in Biosplice Therapeutics?

9 investors have backed Biosplice Therapeutics across its funding rounds, including Vickers Venture Partners, Starling Group, Sands Capital Ventures, aMoon Fund, Eventide and Polar Light Ventures.

Lead investors include aMoon Fund, Eventide, Starling Group and Vickers Venture Partners.


Biosplice Therapeutics Investors

Investors in Biosplice Therapeutics by funding rounds participated
InvestorHQRoundsRoleFirst check
Starling GroupUAEDubai2LeadSep 2013
Vickers Venture PartnersSingaporeSingapore2LeadSep 2013
SwicorpSaudi ArabiaRiyadh1ParticipantAug 2018
EventideUnited StatesBoston, MA1LeadApr 2021
Verition Fund ManagementUnited StatesGreenwich, CT1ParticipantApr 2021
aMoon FundIsraelRa'anana1LeadApr 2021
Sands Capital VenturesUnited StatesWashington, DC1ParticipantApr 2021

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Biosplice Therapeutics Competitors

Biosplice Therapeutics competitors include listed companies like Baxter International and Zydus Lifesciences, and private ones like Biomat USA, ArsenalBio, BioRay Pharmaceuticals and Rakuten Medical.

Public and private companies comparable to Biosplice Therapeutics
CompanyHQStatusRevenueEBITDAValuationRevenue Multiple
Baxter InternationalUnited StatesUnited StatesPublicly listed$11B$714M$12B1.7x
Zydus LifesciencesIndiaIndiaPublicly listed$2.8B$831M$12B4.2x
Biomat USAUnited StatesLos Angeles, CAPrivate--$4.2B-
ArsenalBioUnited StatesUnited StatesPrivate--$1.9B-
BioRay PharmaceuticalsChinaShanghaiPrivate$131M-$1.9B14.5x
Rakuten MedicalUnited StatesSan Diego, CAPrivate--$1.7B-

Biosplice Therapeutics Public Comps

Biosplice Therapeutics is still privately-owned, but its public comps include Baxter International, Zydus Lifesciences, Fresenius Medical Care, Smith & Nephew, United Imaging, Wuxi XDC, Madrigal Pharmaceuticals, Corcept Therapeutics, Cipla and Recordati.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
Baxter International$11B$714M1.7x1.7x27.2x8.5x
Zydus Lifesciences$2.8B$831M4.6x4.2x15.5x16.7x
Fresenius Medical Care$23B$3.8B1.1x1.1x6.4x6.0x
Smith & Nephew$6.2B$1.5B2.4x2.3x9.8x8.9x
United Imaging$2.1B$367M5.5x4.8x30.7x26.9x
Wuxi XDC$886M$256M13.1x10.4x45.4x33.3x
Madrigal Pharmaceuticals$958M($302M)12.4x8.7x(39.3x)-
Corcept Therapeutics$761M$47M15.9x12.0x259.2x59.8x

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Common questions about Biosplice Therapeutics

When was Biosplice Therapeutics founded?Biosplice Therapeutics was founded in 2008.
Where is Biosplice Therapeutics headquartered?Biosplice Therapeutics is headquartered in San Diego, CA, United States.
Is Biosplice Therapeutics publicly listed?No, Biosplice Therapeutics is a private, VC-backed company.
What is Biosplice Therapeutics' valuation?Biosplice Therapeutics was last valued at $12B in its Series B in August 2018.
How much funding has Biosplice Therapeutics raised?Biosplice Therapeutics has raised $778M across 3 funding rounds.
What was Biosplice Therapeutics' last funding round?Biosplice Therapeutics' last funding round was a $120M undisclosed-stage round in April 2021, led by aMoon Fund and Eventide.
Who are Biosplice Therapeutics' investors?Biosplice Therapeutics' investors include Starling Group, Vickers Venture Partners, Swicorp, Eventide, Verition Fund Management, aMoon Fund, Sands Capital Ventures, Polar Light Ventures and Symbiosis Group.
Which companies are comparable to Biosplice Therapeutics?Companies comparable to Biosplice Therapeutics include Baxter International, Zydus Lifesciences, Biomat USA, ArsenalBio, BioRay Pharmaceuticals and Rakuten Medical.

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