Stoke Therapeutics - Public Comps and Valuation Multiples

Stoke Therapeutics Overview

About Stoke Therapeutics

Stoke Therapeutics Inc is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Its proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to restore naturally-occurring protein levels selectively. Its first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome. The company provides early programs focused on multiple targets, including haploinsufficiency diseases of the central nervous system and eye, to up-regulate the protein expression of the underlying disease gene in a mutation-agnostic manner.

Founded

2014

HQ

Employees

128

Website

stoketherapeutics.com

Sectors

Drug Development & Therapeutics
Biopharmaceuticals
BioTech

Financials

LTM Revenue $141M

LTM EBITDA -$22.3M

EV

$1.0B

Valuation Multiples

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Stoke Therapeutics Financials

As of August 2025, Stoke Therapeutics reported last 12-month revenue of $141M and EBITDA of -$22.3M.

In the same period, Stoke Therapeutics achieved -$15.9M in LTM net income.

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Stoke Therapeutics P&L

In the most recent fiscal year, Stoke Therapeutics reported revenue of $36.6M and EBITDA of -$99.2M.

Stoke Therapeutics expects next 12-month revenue of XXX and NTM EBITDA of XXX

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	LTM	NTM	Last FY	FY 2025	FY 2026	FY 2027
Revenue	$141M	XXX	$36.6M	XXX	XXX	XXX
Gross Profit	n/a	XXX	n/a	XXX	XXX	XXX
Gross Margin	n/a	XXX	n/a	XXX	XXX	XXX
EBITDA	-$22.3M	XXX	-$99.2M	XXX	XXX	XXX
EBITDA Margin	-16%	XXX	-271%	XXX	XXX	XXX
EBIT	-$28.0M	XXX	-$101M	XXX	XXX	XXX
EBIT Margin	-20%	XXX	-277%	XXX	XXX	XXX
Net Profit	-$15.9M	XXX	-$89.0M	XXX	XXX	XXX
Net Margin	-11%	XXX	-243%	XXX	XXX	XXX
Net Debt	XXX	XXX	n/a	XXX	XXX	XXX

Financial data powered by Morningstar, Inc.

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Financial performance metrics for Stoke Therapeutics including revenue, profitability, and margin analysis across different time periods. The company reported last twelve months revenue of $141M. EBITDA for the last twelve months was -$22.3M. In the most recent fiscal year, Stoke Therapeutics achieved $36.6M in revenue and -$99.2M in EBITDA.
Financial Metric	Last Twelve Months (LTM)	Next Twelve Months (NTM)	Most Recent Fiscal Year	Current Fiscal Year (2025)	Next Fiscal Year (2026)	Two Years Forward (2027)
Total Revenue	$141M	Analyst estimates available to subscribers	$36.6M	Analyst estimates available to subscribers	Analyst estimates available to subscribers	Analyst estimates available to subscribers
Gross Profit	n/a	Analyst estimates available to subscribers	n/a	Analyst estimates available to subscribers	Analyst estimates available to subscribers	Analyst estimates available to subscribers
Gross Profit Margin	n/a	Analyst estimates available to subscribers	NaN% gross profit margin	Analyst estimates available to subscribers	Analyst estimates available to subscribers	Analyst estimates available to subscribers
EBITDA (Earnings Before Interest, Taxes, Depreciation, Amortization)	-$22.3M	Analyst estimates available to subscribers	-$99.2M	Analyst estimates available to subscribers	Analyst estimates available to subscribers	Analyst estimates available to subscribers
EBITDA Margin	-15.8% EBITDA margin	Analyst estimates available to subscribers	-271.4% EBITDA margin	Analyst estimates available to subscribers	Analyst estimates available to subscribers	Analyst estimates available to subscribers
EBIT (Earnings Before Interest and Taxes)	-$28.0M	Analyst estimates available to subscribers	-$101M	Analyst estimates available to subscribers	Analyst estimates available to subscribers	Analyst estimates available to subscribers
EBIT Margin	-19.8% EBIT margin	Analyst estimates available to subscribers	-277.3% EBIT margin	Analyst estimates available to subscribers	Analyst estimates available to subscribers	Analyst estimates available to subscribers
Net Income (Net Profit)	-$15.9M	Analyst estimates available to subscribers	-$89.0M	Analyst estimates available to subscribers	Analyst estimates available to subscribers	Analyst estimates available to subscribers
Net Profit Margin	-11.2% net profit margin	Analyst estimates available to subscribers	-243.4% net profit margin	Analyst estimates available to subscribers	Analyst estimates available to subscribers	Analyst estimates available to subscribers
Net Debt Position	Detailed debt information available to subscribers	Detailed debt information available to subscribers	n/a	Detailed debt information available to subscribers	Detailed debt information available to subscribers	Detailed debt information available to subscribers

Financial Performance Summary for Stoke Therapeutics

This financial data table provides comprehensive performance metrics for Stoke Therapeutics, a company based in United States of America. The metrics include revenue, profitability measures, and operational efficiency indicators across multiple time periods.

Recent Performance Highlights

Stoke Therapeutics generated $141M in revenue over the last twelve months.
The company achieved -$22.3M in EBITDA over the last twelve months.
Net income over the last twelve months reached -$15.9M.

Fiscal Year Performance

In the most recent fiscal year, Stoke Therapeutics reported $36.6M in total revenue.
Fiscal year EBITDA was -$99.2M.
The company maintained a gross profit margin of NaN% in the most recent fiscal year.
EBITDA margin for the fiscal year was -271.4%.
Net profit margin reached -243.4% in the most recent fiscal year.

This financial data is sourced from Morningstar, Inc. and represents the most recent available information for Stoke Therapeutics. Forward-looking estimates and detailed financial projections are available through our premium subscription service.

Stoke Therapeutics Stock Performance

Stoke Therapeutics has current market cap of $1.3B, and EV of $1.0B.

Market Cap Evolution

Stoke Therapeutics Stock Data

As of September 12, 2025, Stoke Therapeutics's stock price is $23.

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EV	Market Cap	Price 1D	Price 1M	Price 3M	Price 12M	EPS
$1.0B	$1.3B	XXX	XXX	XXX	XXX	$-0.29

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Stoke Therapeutics Valuation Multiples

Stoke Therapeutics's trades at 28.5x EV/Revenue multiple, and -10.5x EV/EBITDA.

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Stoke Therapeutics Financial Valuation Multiples

As of September 12, 2025, Stoke Therapeutics has market cap of $1.3B and EV of $1.0B.

Equity research analysts estimate Stoke Therapeutics's 2025E EV/Revenue multiple at XXX and 2025E EV/EBITDA multiple at XXX

Stoke Therapeutics has a P/E ratio of -80.8x.

	LTM	NTM	Last FY	FY 2025	FY 2026	FY 2027
Market cap (current)	$1.3B	XXX	$1.3B	XXX	XXX	XXX
EV (current)	$1.0B	XXX	$1.0B	XXX	XXX	XXX
EV/Revenue	7.4x	XXX	28.5x	XXX	XXX	XXX
EV/EBITDA	-46.7x	XXX	-10.5x	XXX	XXX	XXX
EV/EBIT	-37.2x	XXX	-10.3x	XXX	XXX	XXX
EV/Gross Profit	n/a	XXX	n/a	XXX	XXX	XXX
P/E	-80.8x	XXX	-14.4x	XXX	XXX	XXX
EV/FCF	63.4x	XXX	-11.9x	XXX	XXX	XXX

Valuation data powered by FactSet, Inc. and Morningstar, Inc.

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Stoke Therapeutics Margins & Growth Rates

Stoke Therapeutics's last 12 month revenue growth is -48%

Stoke Therapeutics's revenue per employee in the last FY averaged $0.3M, while opex per employee averaged $1.1M for the same period.

Stoke Therapeutics's rule of 40 is -1327% (metric relevant for SaaS companies only, counted as combined revenue growth rate and EBITDA margin).

Stoke Therapeutics's rule of X is -136% (created by Bessemer, rule of X is another metric relevant for SaaS companies only, ~1.5x stronger vs. the traditional Rule of 40, counted as revenue growth rate multiplied by 2.5 plus EBITDA margin).

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Stoke Therapeutics Operational Valuation Multiples

	LTM	NTM	Last FY	FY 2025	FY 2026	FY 2027
Revenue Growth	-48%	XXX	-15%	XXX	XXX	XXX
EBITDA Margin	-16%	XXX	-271%	XXX	XXX	XXX
EBITDA Growth	425%	XXX	n/a	XXX	XXX	XXX
Rule of 40	-1327%	XXX	-319%	XXX	XXX	XXX
Bessemer Rule of X	XXX	XXX	-136%	XXX	XXX	XXX
Revenue per Employee	XXX	XXX	$0.3M	XXX	XXX	XXX
Opex per Employee	XXX	XXX	$1.1M	XXX	XXX	XXX
S&M Expenses to Revenue	XXX	XXX	n/a	XXX	XXX	XXX
G&A Expenses to Revenue	XXX	XXX	n/a	XXX	XXX	XXX
R&D Expenses to Revenue	XXX	XXX	244%	XXX	XXX	XXX
Opex to Revenue	XXX	XXX	377%	XXX	XXX	XXX

Valuation data powered by FactSet, Inc. and Morningstar, Inc.

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