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Silence Therapeutics PLC is a biotechnology company focused on discovering and developing novel molecules incorporating short-interfering ribonucleic acid or siRNA. Using its mRNAi GOLD platform, the company has generated siRNA product candidates both for internal development pipeline as well as for out-licensed programs with third-party collaborators. Its wholly owned pipeline is focused on three therapeutic areas: cardiovascular disease, hematology, and rare diseases. The different product candidates in its pipeline are Divesiran (SLN124), a siRNA product candidate that has the potential to treat several hematological disorders; Zerlasiran (SLN360), being developed as a potential treatment to reduce cardiovascular issues; SLN-312; SLN-548; and multiple other programs.
1994
116
LTM Revenue $41.6M
LTM EBITDA -$67.1M
-$76.4M
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Silence Therapeutics has a last 12-month revenue of $41.6M and a last 12-month EBITDA of -$67.1M.
In the most recent fiscal year, Silence Therapeutics achieved revenue of $43.3M and an EBITDA of -$49.0M.
Silence Therapeutics expects next 12-month revenue of XXX and NTM EBITDA of XXX
See Silence Therapeutics valuation multiples based on analyst estimates| FY 2023 | FY 2024 | FY 2025 | LTM | NTM | |
|---|---|---|---|---|---|
| Revenue | $32.3M | $43.3M | XXX | XXX | XXX |
| Gross Profit | $8.0M | $19.2M | XXX | XXX | XXX |
| Gross Margin | 25% | 44% | XXX | XXX | XXX |
| EBITDA | -$63.4M | -$49.0M | XXX | XXX | XXX |
| EBITDA Margin | -196% | -113% | XXX | XXX | XXX |
| Net Profit | -$49.0M | -$55.1M | XXX | XXX | XXX |
| Net Margin | -152% | -127% | XXX | XXX | XXX |
| Net Debt | n/a | n/a | XXX | XXX | XXX |
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As of April 15, 2025, Silence Therapeutics's stock price is $1.
Silence Therapeutics has current market cap of $70.8M, and EV of -$76.4M.
See Silence Therapeutics trading valuation data| EV | Market Cap | Price 1D | Price 1M | Price 3M | Price 12M | EPS |
|---|---|---|---|---|---|---|
| -$76.4M | $70.8M | XXX | XXX | XXX | XXX | $-0.12 |
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Sign UpAs of April 15, 2025, Silence Therapeutics has market cap of $70.8M and EV of -$76.4M.
Silence Therapeutics's trades at -2.4x LTM EV/Revenue multiple, and 1.5x LTM EBITDA.
Analysts estimate Silence Therapeutics's 2025E EV/Revenue multiple at XXX and 2025E EV/EBITDA multiple at XXX
See valuation multiples for Silence Therapeutics and 10K+ public comps| FY 2024 | FY 2025E | FY 2026E | FY 2027E | |
|---|---|---|---|---|
| EV | -$76.4M | XXX | XXX | XXX |
| EV/Revenue | -1.8x | XXX | XXX | XXX |
| EV/EBITDA | 1.6x | XXX | XXX | XXX |
| P/E | -1.6x | XXX | XXX | XXX |
| P/E/Growth | n/a | XXX | XXX | XXX |
| EV/FCF | 1.1x | XXX | XXX | XXX |
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Access all public comps and forward-looking valuation multiples like EV/Revenue in 2025, based on equity research analyst estimates.
Sign UpSilence Therapeutics's NTM/LTM revenue growth is -22%
Silence Therapeutics's revenue per employee for the last fiscal year averaged $0.4M, while opex per employee averaged $0.7M for the same period.
Over next 12 months, Silence Therapeutics's ratio of sales and marketing spend to revenue is estimated to be XXX , while its R&D spend to revenue to be XXX .
Analysts estimate Silence Therapeutics's 2025E EV/Revenue multiple at XXX and 2025E EV/EBITDA multiple at XXX
See operational valuation multiples for Silence Therapeutics and other 10K+ public comps| FY 2024 | NTM | FY 2025E | FY 2026E | FY 2027E | |
|---|---|---|---|---|---|
| Revenue Growth | 34% | XXX | XXX | XXX | XXX |
| EBITDA Margin | -113% | XXX | XXX | XXX | XXX |
| EBITDA Growth | -23% | XXX | XXX | XXX | XXX |
| Rule of 40 (SaaS-only) | -136% | XXX | XXX | XXX | XXX |
| Revenue per Employee | $0.4M | XXX | XXX | XXX | XXX |
| Opex per Employee | $0.7M | XXX | XXX | XXX | XXX |
| S&M Expenses to Revenue | n/a | XXX | XXX | XXX | XXX |
| G&A Expenses to Revenue | 62% | XXX | XXX | XXX | XXX |
| R&D Expenses to Revenue | 157% | XXX | XXX | XXX | XXX |
| Opex to Revenue | 187% | XXX | XXX | XXX | XXX |
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Benchmark public comps and private revenue and EBITDA valuation multiples across GRC software, cloud infrastructure, DevOps, online marketplaces and so much more!
| EV/Revenue | EV/EBITDA | |||||
|---|---|---|---|---|---|---|
| 2025E | 2026E | 2027E | 2025E | 2026E | 2027E | |
| Julphar | XXX | XXX | XXX | XXX | XXX | XXX |
| Benevolent AI | XXX | XXX | XXX | XXX | XXX | XXX |
| Galapagos | XXX | XXX | XXX | XXX | XXX | XXX |
| Pharming | XXX | XXX | XXX | XXX | XXX | XXX |
| Vivoryon Therapeutics | XXX | XXX | XXX | XXX | XXX | XXX |
| XXXXXXXX | XXX | XXX | XXX | XXX | XXX | XXX |
| XXXXXXXX | XXX | XXX | XXX | XXX | XXX | XXX |
Valuation data powered by FactSet, Inc.
Silence Therapeutics acquired XXX companies to date.
Last acquisition by Silence Therapeutics was XXXXXXXX, XXXXX XXXXX XXXXXX . Silence Therapeutics acquired XXXXXXXX for XXX (EV/Revenue multiple of XXX ).
See M&A valuation multiples| Acquired Company | EV | EV/Revenue | EV/EBITDA |
|---|---|---|---|
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
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Sign Up| When was Silence Therapeutics founded? | Silence Therapeutics was founded in 1994. |
| Where is Silence Therapeutics headquartered? | Silence Therapeutics is headquartered in United States of America. |
| How many employees does Silence Therapeutics have? | As of today, Silence Therapeutics has 116 employees. |
| Who is the CEO of Silence Therapeutics? | Silence Therapeutics's CEO is Mr. Craig A. Tooman. |
| Is Silence Therapeutics publicy listed? | Yes, Silence Therapeutics is a public company listed on PINX. |
| What is the stock symbol of Silence Therapeutics? | Silence Therapeutics trades under SLNCF ticker. |
| When did Silence Therapeutics go public? | Silence Therapeutics went public in 2007. |
| Who are competitors of Silence Therapeutics? | Similar companies to Silence Therapeutics include e.g. Julphar, Benevolent AI, Galapagos, Pharming. |
| What is the current market cap of Silence Therapeutics? | Silence Therapeutics's current market cap is $70.8M |
| What is the current revenue of Silence Therapeutics? | Silence Therapeutics's last 12-month revenue is $41.6M. |
| What is the current EBITDA of Silence Therapeutics? | Silence Therapeutics's last 12-month EBITDA is -$67.1M. |
| What is the current EV/Revenue multiple of Silence Therapeutics? | Current revenue multiple of Silence Therapeutics is -2.4x. |
| What is the current EV/EBITDA multiple of Silence Therapeutics? | Current EBITDA multiple of Silence Therapeutics is 1.5x. |
| What is the current revenue growth of Silence Therapeutics? | Silence Therapeutics revenue growth between 2023 and 2024 was 34%. |
| Is Silence Therapeutics profitable? | Yes, Silence Therapeutics is EBITDA-positive (as of the last 12 months). |
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