XyloCor Therapeutics Funding, Investors & Competitors

XyloCor Therapeutics has raised $107M across 3 funding rounds, most recently a $68M Series B in January 2025.

Last XyloCor Therapeutics funding round

$68M

Series B · Jan 2025

Cumulative funding XyloCor Therapeutics raised

$107M

across 3 funding rounds

Key investors in XyloCor Therapeutics

  • EQT
  • Sofinnova Investments
  • Lumira Ventures
  • Fountain Healthcare Partners
  • Longwood Fund
  • Jeito Capital

XyloCor Therapeutics Overview

About XyloCor Therapeutics

XyloCor Therapeutics develops gene therapies for refractory angina in coronary artery disease patients. United States-based, its lead XC001 delivers FGF-1 via plasmid vector to promote angiogenesis. Collaborating with Weill Cornell Medicine, XyloCor advances Phase 2 trials targeting patients ineligible for stents or bypass.


Founded

2013

HQ

United StatesPhiladelphia, PA

Status

Privately held

Customer focus

B2C

Revenue model

Product sales

XyloCor Therapeutics Funding History

XyloCor Therapeutics has raised a total of $107M across 3 funding rounds.

XyloCor Therapeutics' first fundraising round was a $17M Series A in December 2018. The most recent completed round was a $68M Series B in January 2025.

XyloCor Therapeutics funding rounds

XyloCor Therapeutics funding rounds
DateStageInvestorsRaisedDeal Summary
Jan 2025Series BJeito Capital (lead); EQT; Lumira Ventures; Fountain Healthcare Partners$68MXyloCor Therapeutics, a US-based clinical-stage biopharmaceutical company headquartered in King of Prussia, Pennsylvania, develops novel gene therapies for cardiovascular disease, with its lead candidate XC001 (encoberminogene rezmadenovec) targeting refractory angina via a non-surgical endocardial delivery method using a novel injection catheter. The company completed a $67.5 million Series B financing round on January 7, 2025, led by new investor Jeito Capital, with participation from existing investors EQT, Fountain Healthcare Partners, and Lumira Ventures. Rachel Mears from Jeito Capital joined the XyloCor Board of Directors. Proceeds will fund two randomized, double-blind Phase 2 clinical trials: EXACT-2 for XC001 in refractory angina and a second trial evaluating XC001 as an adjunctive treatment to coronary artery bypass graft (CABG) surgery. XC001 addresses unmet needs for over one million US patients with chronic cardiovascular conditions lacking treatment options, building on prior achievements in advancing this gene therapy approach. Jeito Capital, a Paris-based private equity firm with €534 million under management specializing in biopharma, emphasized XyloCor's experienced leadership, world-class cardiologists, and scientists, aligning with its strategy to accelerate game-changing innovations in cardiology for faster patient access in Europe and the US.
Mar 2021Series AFountain Healthcare Partners (lead); EQT; Longwood Fund; Lumira Ventures; Sofinnova Investments$23MXyloCor Therapeutics is a clinical-stage biopharmaceutical company developing novel gene therapies for cardiovascular disease, particularly advanced coronary artery disease and refractory angina. Its lead candidate, XC001 (encoberminogene rezmadenovec), is an investigational gene therapy studied in Phase 1/2 trials, including the EXACT study for refractory angina and as an adjunct to coronary artery bypass graft (CABG) surgery for high-risk patients. On March 22, 2021, XyloCor closed an additional $22.6 million in its oversubscribed Series A financing (labeled Series A - III), led by Fountain Healthcare Partners with participation from new investors Longwood Fund and Lumira Ventures, plus existing investors Sofinnova Investments and LSP (Life Sciences Partners). This brought total investment to $41.9 million since its 2018 Series A start, building on a prior $17-19 million tranche. Proceeds funded initiation of a new clinical trial for XC001 in CABG patients and expansion of the refractory angina program. Aidan King from Fountain Healthcare Partners, Daniel Hétu from Lumira Ventures, and Perry Nisen from Sofinnova Investments joined the board. Later, XyloCor raised a $67.5 million Series B on January 7, 2025, led by Jeito Capital with EQT Life Sciences, Fountain Healthcare Partners, and Lumira Ventures; one source mentions a $130M current valuation but not tied to 2021. The company has raised over $111M across 8 rounds total, focusing on advancing XC001 to Phase 2b trials (EXACT-2) via non-surgical delivery.
Dec 2018Series AEQT (lead); Sofinnova Investments (lead)$17MXyloCor Therapeutics is a biopharmaceutical company developing gene therapies for cardiovascular disease, focusing on refractory angina with lead candidate XC001, a cardiovascular angiogenic gene therapy. On December 6, 2018, XyloCor closed a $17 million Series A financing round co-led by Sofinnova Ventures and LSP (Life Sciences Partners), with EQT mentioned in later contexts but not as a lead for this specific round. Proceeds funded advancement of XC001 development and expansion of business operations. Al Gianchetti, former GlaxoSmithKline executive, served as CEO. This initial Series A was later extended in multiple tranches, reaching $41.9 million total by 2021 with participation from Sofinnova Investments and LSP, joined by Fountain Healthcare Partners, Longwood Fund, and Lumira Ventures. The company progressed XC001 to a Phase 1/2 clinical trial (EXACT). Subsequent rounds included a $67.5 million Series B in January 2025 led by Jeito Capital with EQT Life Sciences and others.

Who has invested in XyloCor Therapeutics?

6 investors have backed XyloCor Therapeutics across its funding rounds, including EQT, Sofinnova Investments, Lumira Ventures, Fountain Healthcare Partners, Longwood Fund and Jeito Capital.

Lead investors include Jeito Capital, Fountain Healthcare Partners, EQT and Sofinnova Investments.


XyloCor Therapeutics Investors

Investors in XyloCor Therapeutics by funding rounds participated
InvestorHQRoundsRoleFirst check
EQTSwedenStockholm3LeadDec 2018
Lumira VenturesCanadaToronto2ParticipantMar 2021
Fountain Healthcare PartnersUnited StatesNew York City, NY2LeadMar 2021
Sofinnova InvestmentsUnited StatesSan Francisco, CA2LeadDec 2018

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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples

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XyloCor Therapeutics Competitors

XyloCor Therapeutics competitors include listed companies like Roche and Johnson & Johnson, and private ones like Heyuan Biotechnology, ArsenalBio, Formation Bio and Immunai.

Public and private companies comparable to XyloCor Therapeutics
CompanyHQStatusRevenueEBITDAValuationRevenue Multiple
RocheSwitzerlandSwitzerlandPublicly listed$77B$26B$346B4.9x
Heyuan BiotechnologyChinaShanghaiPrivate--$3B-
ArsenalBioUnited StatesUnited StatesPrivate--$1.9B-
Formation BioUnited StatesNew York City, NYPrivate--$1B-
ImmunaiUnited StatesNew York City, NYPrivate--$1B-
Johnson & JohnsonUnited StatesUnited StatesPublicly listed$94B$40B$651B6.8x

XyloCor Therapeutics Public Comps

XyloCor Therapeutics is still privately-owned, but its public comps include Eli Lilly, Johnson & Johnson, AbbVie, Merck, Roche, Novartis, AstraZeneca, Amgen, Novo Nordisk and Gilead Sciences.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
Eli Lilly$65B$28B16.5x13.1x38.7x27.0x
Johnson & Johnson$94B$40B7.2x6.8x17.0x18.3x
AbbVie$61B$17B8.7x8.1x30.6x17.6x
Merck$65B$28B6.3x6.1x14.7x21.0x
Roche$77B$26B4.9x4.9x14.5x12.2x
Novartis$57B$22B5.4x5.4x14.0x13.2x
AstraZeneca$59B$19B4.9x4.6x14.9x12.9x
Amgen$37B$17B6.9x6.6x15.0x14.6x

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Common questions about XyloCor Therapeutics

When was XyloCor Therapeutics founded?XyloCor Therapeutics was founded in 2013.
Where is XyloCor Therapeutics headquartered?XyloCor Therapeutics is headquartered in Philadelphia, PA, United States.
Is XyloCor Therapeutics publicly listed?No, XyloCor Therapeutics is a private, VC-backed company.
How much funding has XyloCor Therapeutics raised?XyloCor Therapeutics has raised $107M across 3 funding rounds.
What was XyloCor Therapeutics' last funding round?XyloCor Therapeutics' last funding round was a $68M Series B in January 2025, led by Jeito Capital.
Who are XyloCor Therapeutics' investors?XyloCor Therapeutics' investors include EQT, Lumira Ventures, Fountain Healthcare Partners, Sofinnova Investments, Longwood Fund and Jeito Capital.
Which companies are comparable to XyloCor Therapeutics?Companies comparable to XyloCor Therapeutics include Roche, Heyuan Biotechnology, ArsenalBio, Formation Bio, Immunai and Johnson & Johnson.

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