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Denali Therapeutics Inc is a biotechnology company that is engaged in developing and discovering therapeutics to defeat neurodegeneration disease. The company's development programs include the LRRK2 Inhibitor Program, which develops brain penetrant small molecule LRRK2 inhibitor product candidates for Parkinson's disease. Its key products include DNL201, DNL151, DNL747, ATV (Antibody Transport Vehicle), ETV (Enzyme Transport Vehicle), and others.
2013
422
LTM Revenue $6.4M
LTM EBITDA -$466M
$1.4B
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Denali Therapeutics has a last 12-month revenue of $6.4M and a last 12-month EBITDA of -$466M.
In the most recent fiscal year, Denali Therapeutics achieved revenue of n/a and an EBITDA of -$493M.
Denali Therapeutics expects next 12-month revenue of XXX and NTM EBITDA of XXX
See Denali Therapeutics valuation multiples based on analyst estimates| FY 2023 | FY 2024 | FY 2025 | LTM | NTM | |
|---|---|---|---|---|---|
| Revenue | $331M | n/a | XXX | XXX | XXX |
| Gross Profit | n/a | n/a | XXX | XXX | XXX |
| Gross Margin | NaN% | NaN% | XXX | XXX | XXX |
| EBITDA | -$180M | -$493M | XXX | XXX | XXX |
| EBITDA Margin | -54% | -Infinity% | XXX | XXX | XXX |
| Net Profit | -$326M | -$145M | XXX | XXX | XXX |
| Net Margin | -99% | -Infinity% | XXX | XXX | XXX |
| Net Debt | n/a | n/a | XXX | XXX | XXX |
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As of March 12, 2025, Denali Therapeutics's stock price is $15.
Denali Therapeutics has current market cap of $2.2B, and EV of $1.4B.
See Denali Therapeutics trading valuation data| EV | Market Cap | Price 1D | Price 1M | Price 3M | Price 12M | EPS |
|---|---|---|---|---|---|---|
| $1.4B | $2.2B | XXX | XXX | XXX | XXX | $-2.63 |
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Sign UpAs of March 12, 2025, Denali Therapeutics has market cap of $2.2B and EV of $1.4B.
Denali Therapeutics's trades at 219.6x LTM EV/Revenue multiple, and -3.0x LTM EBITDA.
Analysts estimate Denali Therapeutics's 2025E EV/Revenue multiple at XXX and 2025E EV/EBITDA multiple at XXX
See valuation multiples for Denali Therapeutics and 10K+ public comps| FY 2024 | FY 2025E | FY 2026E | FY 2027E | |
|---|---|---|---|---|
| EV | $1.4B | XXX | XXX | XXX |
| EV/Revenue | n/a | XXX | XXX | XXX |
| EV/EBITDA | -2.8x | XXX | XXX | XXX |
| P/E | -5.2x | XXX | XXX | XXX |
| P/E/Growth | n/a | XXX | XXX | XXX |
| EV/FCF | -3.9x | XXX | XXX | XXX |
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Access all public comps and forward-looking valuation multiples like EV/Revenue in 2025, based on equity research analyst estimates.
Sign UpDenali Therapeutics's NTM/LTM revenue growth is 707%
Denali Therapeutics's revenue per employee for the last fiscal year averaged n/a, while opex per employee averaged $1.2M for the same period.
Over next 12 months, Denali Therapeutics's ratio of sales and marketing spend to revenue is estimated to be XXX , while its R&D spend to revenue to be XXX .
Analysts estimate Denali Therapeutics's 2025E EV/Revenue multiple at XXX and 2025E EV/EBITDA multiple at XXX
See operational valuation multiples for Denali Therapeutics and other 10K+ public comps| FY 2024 | NTM | FY 2025E | FY 2026E | FY 2027E | |
|---|---|---|---|---|---|
| Revenue Growth | -100% | XXX | XXX | XXX | XXX |
| EBITDA Margin | n/a | XXX | XXX | XXX | XXX |
| EBITDA Growth | 174% | XXX | XXX | XXX | XXX |
| Rule of 40 (SaaS-only) | n/a | XXX | XXX | XXX | XXX |
| Revenue per Employee | n/a | XXX | XXX | XXX | XXX |
| Opex per Employee | $1.2M | XXX | XXX | XXX | XXX |
| S&M Expenses to Revenue | n/a | XXX | XXX | XXX | XXX |
| G&A Expenses to Revenue | n/a | XXX | XXX | XXX | XXX |
| R&D Expenses to Revenue | n/a | XXX | XXX | XXX | XXX |
| Opex to Revenue | n/a | XXX | XXX | XXX | XXX |
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Benchmark public comps and private revenue and EBITDA valuation multiples across GRC software, cloud infrastructure, DevOps, online marketplaces and so much more!
| EV/Revenue | EV/EBITDA | |||||
|---|---|---|---|---|---|---|
| 2025E | 2026E | 2027E | 2025E | 2026E | 2027E | |
| Julphar | XXX | XXX | XXX | XXX | XXX | XXX |
| Benevolent AI | XXX | XXX | XXX | XXX | XXX | XXX |
| Galapagos | XXX | XXX | XXX | XXX | XXX | XXX |
| Pharming | XXX | XXX | XXX | XXX | XXX | XXX |
| Vivoryon Therapeutics | XXX | XXX | XXX | XXX | XXX | XXX |
| XXXXXXXX | XXX | XXX | XXX | XXX | XXX | XXX |
| XXXXXXXX | XXX | XXX | XXX | XXX | XXX | XXX |
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Denali Therapeutics acquired XXX companies to date.
Last acquisition by Denali Therapeutics was XXXXXXXX, XXXXX XXXXX XXXXXX . Denali Therapeutics acquired XXXXXXXX for XXX (EV/Revenue multiple of XXX ).
See M&A valuation multiples| Acquired Company | EV | EV/Revenue | EV/EBITDA |
|---|---|---|---|
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
| XXXXXXXXX | XXX | XXX | XXX |
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Sign Up| When was Denali Therapeutics founded? | Denali Therapeutics was founded in 2013. |
| Where is Denali Therapeutics headquartered? | Denali Therapeutics is headquartered in United States of America. |
| How many employees does Denali Therapeutics have? | As of today, Denali Therapeutics has 422 employees. |
| Who is the CEO of Denali Therapeutics? | Denali Therapeutics's CEO is Dr. Ryan J. Watts, PhD. |
| Is Denali Therapeutics publicy listed? | Yes, Denali Therapeutics is a public company listed on NAS. |
| What is the stock symbol of Denali Therapeutics? | Denali Therapeutics trades under DNLI ticker. |
| When did Denali Therapeutics go public? | Denali Therapeutics went public in 2017. |
| Who are competitors of Denali Therapeutics? | Similar companies to Denali Therapeutics include e.g. Julphar, Benevolent AI, Galapagos, Pharming. |
| What is the current market cap of Denali Therapeutics? | Denali Therapeutics's current market cap is $2.2B |
| What is the current revenue of Denali Therapeutics? | Denali Therapeutics's last 12-month revenue is $6.4M. |
| What is the current EBITDA of Denali Therapeutics? | Denali Therapeutics's last 12-month EBITDA is -$466M. |
| What is the current EV/Revenue multiple of Denali Therapeutics? | Current revenue multiple of Denali Therapeutics is 219.6x. |
| What is the current EV/EBITDA multiple of Denali Therapeutics? | Current EBITDA multiple of Denali Therapeutics is -3.0x. |
| Is Denali Therapeutics profitable? | Yes, Denali Therapeutics is EBITDA-positive (as of the last 12 months). |
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