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- Matchpoint Therapeutics
Matchpoint Therapeutics Funding, Investors & Competitors
Matchpoint Therapeutics has raised $250M across 3 funding rounds, most recently a $150M Series B in October 2026.
Last Matchpoint Therapeutics funding round
$150M
Series B · Oct 2026
Cumulative funding Matchpoint Therapeutics raised
$250M
across 3 funding rounds
Key investors in Matchpoint Therapeutics
Atlas Venture
Access Biotechnology
Sanofi Ventures
Digitalis Ventures
Alexandria Venture Investments
Invus
Nextech Invest
JDRF T1D Fund
About Matchpoint Therapeutics
Matchpoint Therapeutics is a San Francisco-headquartered biotechnology firm developing covalent medicines for immunology. Its Advanced Covalent Exploration platform combines chemoproteomics, machine learning, and chemistry libraries. The pipeline targets immune diseases with precision inhibitors. Matchpoint advances candidates through preclinical stages via matchpointtx.com.
Founded
2021
HQ
Website
Status
Privately held
Customer focus
B2B
Revenue model
Product sales
Sectors
Matchpoint Therapeutics Funding History
Matchpoint Therapeutics has raised a total of $250M across 3 funding rounds.
Matchpoint Therapeutics' first fundraising round was a $30M seed round in November 2021. The most recent completed round was a $150M Series B in October 2026.
Matchpoint Therapeutics funding rounds
| Date | Stage | Investors | Raised | Deal Summary |
|---|---|---|---|---|
| Oct 2026 | Series B | Nextech Invest (lead); Norwest Corporation (lead); Digitalis Ventures; JDRF T1D Fund; BOLD Longevity Growth Fund; Invus; BB Biotech; Atlas Venture; Sanofi Ventures; Access Biotechnology | $150M | Nextech Invest and Norwest co-led a $150 million Series B financing in Matchpoint Therapeutics, which the company announced on 7 October 2026, with new investors Invus, BB Biotech, T1D Fund and BOLD Longevity Growth. Existing investors Access Biotechnology, Atlas Venture, Sanofi Ventures and Digitalis Ventures also participated, according to the company. The round follows a $70 million Series A led by Sanofi Ventures in 2022 and a $30 million seed round in 2021, according to MedPath. Kanishka Pothula of Nextech Invest and Brian Matesic of Norwest will join the company's board of directors. Chief executive Andre Turenne said the financing reflects substantial progress in discovering differentiated, first-in-class oral therapies for autoimmune and inflammatory diseases. The company, based in Watertown, Massachusetts, said the proceeds will advance its lead program MPT-062 into clinical development. Matchpoint is a biotechnology company that discovers precision covalent medicines, which form an irreversible bond with a single reactive amino acid in a disease-causing protein. |
| Oct 2022 | Series A | Sanofi Ventures (lead); Digitalis Ventures; Vertex Ventures HC; Alexandria Venture Investments; Atlas Venture; Access Biotechnology | $70M | Matchpoint Therapeutics is a biotechnology company founded in 2021 and based in Cambridge, Massachusetts, focused on leveraging covalency for the discovery of precision small molecule medicines, particularly for immunology and immune diseases. The company develops covalent drugs using its proprietary Advanced Covalent Exploration (ACE) platform, which identifies pathogenic proteins and utilizes proprietary libraries of covalent compounds. Founded by experts in covalent chemistry, proteomics, and computational sciences from Stanford University and Harvard Medical School, Matchpoint targets disease-causing proteins unamenable to traditional small molecule intervention. On October 14, 2022, Matchpoint announced its launch with $100 million in total financing, comprising a $70 million Series A round led by Sanofi Ventures, with participation from Vertex Ventures HC, Digitalis Ventures, Alexandria Venture Investments, Atlas Venture, Access Biotechnology, and other investors. This Series A followed a $30 million seed financing in November 2021 co-led by Atlas Venture and Access Biotechnology. The funds support advancement of the company's platform and discovery pipeline of novel covalent molecules, initially in immunology. Andre Turenne serves as President and CEO, bringing experience from Voyager Therapeutics and Sanofi, while Bruce Booth of Atlas Venture is Chair of the Board. The company positions itself to transform autoimmune and chronic disease treatments using advances in chemoproteomics, computational sciences, and synthetic chemistry. |
| Nov 2021 | Seed | Access Biotechnology (lead); Atlas Venture (lead) | $30M | Matchpoint Therapeutics is a Cambridge, Massachusetts-based biotechnology company founded in 2021 to develop precision covalent small molecule medicines, initially focused on immunology and autoimmune diseases, using its proprietary Advanced Covalent Exploration (ACE) platform for pathogenic protein identification and covalent compound libraries. The company was co-founded by Nathanael Gray from Stanford University and Edward Chouchani from Harvard Medical School and Dana-Farber Cancer Institute, with Andre Turenne, former Sanofi executive and CEO of Voyager Therapeutics, as president and CEO. Atlas Venture partner Bruce Booth serves as board chair. In November 2021, Matchpoint Therapeutics completed a $30 million seed financing round co-led by Atlas Venture and Access Biotechnology, which supported the company's emergence from stealth and initial platform development. This seed round preceded a $70 million Series A financing closed in October 2022 led by Sanofi Ventures, with participation from Vertex Ventures HC, Digitalis Ventures, Alexandria Venture Investments, and existing investors, bringing total funding to $100 million. The combined financing enabled advancement of multiple covalent drug programs targeting cysteine proteins in underserved autoimmune areas. At launch, Matchpoint employed 25 people and planned to expand to 45 by end-2023, while pursuing licensing deals and research collaborations with other drugmakers. The company's approach leverages advances in chemoproteomics, computational sciences, and synthetic chemistry to realize the potential of covalent modalities beyond oncology into chronic immune diseases. |
Who has invested in Matchpoint Therapeutics?
12 investors have backed Matchpoint Therapeutics across its funding rounds, including Atlas Venture, Access Biotechnology, Sanofi Ventures, Digitalis Ventures, Alexandria Venture Investments and Invus.
Lead investors include Nextech Invest, Norwest Corporation, Sanofi Ventures, Access Biotechnology and Atlas Venture.
Matchpoint Therapeutics Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 3 | Lead | Nov 2021 | ||
| 3 | Lead | Nov 2021 | ||
| 2 | Participant | Oct 2022 | ||
| 2 | Lead | Oct 2022 | ||
| 1 | Lead | Oct 2026 | ||
| 1 | Participant | Oct 2026 | ||
| 1 | Participant | Oct 2026 | ||
| 1 | Lead | Oct 2026 | ||
| 1 | Participant | Oct 2022 | ||
| 1 | Participant | Oct 2022 | ||
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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
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Start Free TrialMatchpoint Therapeutics Competitors
Matchpoint Therapeutics competitors include listed companies like Eli Lilly, Johnson & Johnson, AbbVie and Roche, and private ones like Biosplice Therapeutics and Intas Pharmaceuticals.
| Company | HQ | Status | Revenue | EBITDA | Valuation | Revenue Multiple |
|---|---|---|---|---|---|---|
| Publicly listed | $65B | $28B | $1.2T | 14.3x | ||
| Publicly listed | $94B | $40B | $665B | 6.9x | ||
| Publicly listed | $61B | $17B | $515B | 8.8x | ||
| Publicly listed | $78B | $26B | $382B | 5.3x | ||
| Private | - | - | $12B | - | ||
| Private | $2B | - | $8.5B | - |
Matchpoint Therapeutics Public Comps
Matchpoint Therapeutics is still privately-owned, but its public comps include Eli Lilly, Johnson & Johnson, AbbVie, Roche, Merck, Novartis, AstraZeneca, Amgen, Gilead Sciences and Novo Nordisk.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| $65B | $28B | 19.2x | 14.3x | 45.1x | 30.2x | |||
| $94B | $40B | 7.4x | 6.9x | 17.3x | 18.8x | |||
| $61B | $17B | 9.6x | 8.8x | 33.7x | 18.6x | |||
| $78B | $26B | 5.3x | 5.3x | 15.7x | 13.3x | |||
| $65B | $28B | 6.2x | 6.1x | 14.5x | 22.9x | |||
| $57B | $22B | 6.1x | 6.1x | 15.9x | 14.8x | |||
| $59B | $19B | 5.4x | 5.1x | 16.5x | 14.2x | |||
| $37B | $17B | 7.9x | 7.4x | 17.3x | 16.5x | |||
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Common questions about Matchpoint Therapeutics
| When was Matchpoint Therapeutics founded? | Matchpoint Therapeutics was founded in 2021. |
| Where is Matchpoint Therapeutics headquartered? | Matchpoint Therapeutics is headquartered in United States. |
| Is Matchpoint Therapeutics publicly listed? | No, Matchpoint Therapeutics is a private, VC-backed company. |
| How much funding has Matchpoint Therapeutics raised? | Matchpoint Therapeutics has raised $250M across 3 funding rounds. |
| What was Matchpoint Therapeutics' last funding round? | Matchpoint Therapeutics' last funding round was a $150M Series B in October 2026, led by Nextech Invest and Norwest Corporation. |
| Who are Matchpoint Therapeutics' investors? | Matchpoint Therapeutics' investors include Atlas Venture, Access Biotechnology, Digitalis Ventures, Sanofi Ventures, Norwest Corporation, JDRF T1D Fund, BOLD Longevity Growth Fund, Nextech Invest, Vertex Ventures HC, Alexandria Venture Investments and 2 others. |
| Which companies are comparable to Matchpoint Therapeutics? | Companies comparable to Matchpoint Therapeutics include Eli Lilly, Johnson & Johnson, AbbVie, Roche, Biosplice Therapeutics and Intas Pharmaceuticals. |
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