Seismic Therapeutic Valuation, Funding & Investors

Seismic Therapeutic is valued at $210M as of February 2022.

Last Seismic Therapeutic valuation

$210M

Series A · Feb 2022

Last Seismic Therapeutic funding round

$25M

Series B · Sep 2024

Cumulative funding Seismic Therapeutic raised

$247M

across 3 funding rounds

Key investors in Seismic Therapeutic

  • Lightspeed Venture Partners
  • GV
  • Polaris Partners
  • Samsara BioCapital
  • Boxer Capital
  • Timothy A. Springer

Seismic Therapeutic Overview

About Seismic Therapeutic

Seismic Therapeutic is a Boston-based biotech firm using machine learning for biologics discovery in immunology. Its IMPACT platform combines protein engineering, structural modeling, and immune assays to develop antibodies for autoimmune diseases like rheumatoid arthritis. Founded in 2023, it raised $110 million in Series A funding from ARCH Venture Partners.


Founded

2020

HQ

United StatesBoston, MA

Status

Privately held

Customer focus

B2B

Revenue model

Licensing

Valuation

$210M (Feb 2022)

Seismic Therapeutic Valuation

Seismic Therapeutic is currently valued at $210M, based on its Series A in February 2022.

The $101M round was led by Lightspeed Venture Partners, with participation from Boxer Capital, GV, Polaris Partners, Other People's Capital, Timothy A. Springer and 1 other investor.

Seismic Therapeutic valuation by funding round

Seismic Therapeutic valuation by funding round
DateStageValuation
Feb 2022Series A$210M

Seismic Therapeutic Funding History

Seismic Therapeutic has raised a total of $247M across 3 funding rounds.

Seismic Therapeutic's first fundraising round was a $101M Series A in February 2022. The most recent completed round was a $25M Series B in September 2024.

Seismic Therapeutic funding rounds

Seismic Therapeutic funding rounds
DateStageInvestorsRaisedValuationDeal Summary
Sep 2024Series BAbrdn; The Pags Group; SymBiosis$25M-Seismic Therapeutic is a biotechnology company based in Watertown, MA, leveraging its proprietary IMPACT platform that integrates machine learning with structural biology, protein engineering, and translational immunology to develop biologics targeting dysregulated adaptive immunity for autoimmune and inflammatory diseases. The company maintains a preclinical pipeline of best-in-class and first-in-class candidates and is co-founded by CEO Jo Viney, Ph.D. Notable prior investors include Bessemer Venture Partners, Amgen Ventures, Lightspeed Venture Partners, Polaris Partners, and others, supporting its operations in the Boston biotech hub. The company actively engages with the investment community, participating in conferences such as Guggenheim’s Inaugural Healthcare Innovation Conference in November 2024, Stifel Healthcare Conference, Jefferies London Healthcare Conference, Piper Sandler 36th Annual Healthcare Conference, and Wells Fargo Virtual Private Biotech Symposium in December 2024. Recent activities include presentations at the J.P. Morgan Healthcare Conference and Antibody Engineering & Therapeutics US Conference, covering topics like engineering for optimal receptor agonism and structure-based design of proteases to degrade IgE for allergy treatments.
Dec 2023Series BBessemer Venture Partners (lead); Boxer Capital; Amgen Ventures; GC&H Investments; GV; Alexandria Venture Investments; Polaris Partners; Lightspeed Venture Partners; Timothy A. Springer; Gaingels; Samsara BioCapital; Codon Capital$121M-Seismic Therapeutic is a Cambridge, Massachusetts-based biotechnology company specializing in machine learning-driven immunology drug discovery and development. The company uses its proprietary IMPACT platform, a machine learning-enabled system, to advance innovative immunotherapy candidates targeting autoimmune diseases. Seismic's two lead programs include S-1117, a pan-immunoglobulin G protease sculpting enzyme candidate, and S-4321, a PD-1 agonist selective dual-cell bidirectional antibody candidate. In December 2023, Seismic closed a $121 million Series B financing round led by new investor Bessemer Venture Partners, with participation from additional new investors including Amgen Ventures, Codon Capital, Alexandria Venture Investments, Gaingels, and GC&H, alongside existing investors Timothy A. Springer, Lightspeed Venture Partners, Polaris Partners, Boxer Capital, GV, and Samsara BioCapital. The proceeds were designated to advance the two lead programs through Phase 1 proof-of-mechanism trials, expand the pipeline in immunoglobulin-sculpting and dual-cell bidirectional antibody areas, and further develop the IMPACT platform with additional machine learning methodologies to enhance biologics drug discovery. The Series B brought Seismic's total raised capital to $222 million since its founding in 2020, following a $101 million Series A round in 2022. The company's integration of machine learning with immunology expertise positions it to pioneer a new generation of biologics drugs addressing unmet medical needs in autoimmune disease treatment.
Feb 2022Series ALightspeed Venture Partners (lead); Boxer Capital; GV; Polaris Partners; Other People's Capital; Timothy A. Springer; Samsara BioCapital$101M$210MSeismic Therapeutic is a biotechnology company integrating machine learning across the entire biologics discovery process to accelerate immunology drug development. Founded in 2010 and based in Watertown, Massachusetts, the company uses its proprietary IMPACT platform to combine machine learning with structural biology, protein engineering, and translational immunology to create optimized therapies for autoimmune diseases. The company has an emerging pipeline of novel biologics focused on treating adaptive immune system dysregulation. On February 9, 2022, Seismic Therapeutic closed a Series A funding round totaling $101 million, with a post-money valuation of $210.35 million. The round was led by Lightspeed Venture Partners and included participation from Boxer Capital, GV, Polaris Partners, Samsara BioCapital, and Timothy A. Springer. The funding was directed toward advancing two lead drug programs—one targeting Ig-mediated autoimmunity and the other targeting cell-mediated autoimmunity—through IND-enabling studies and supporting continued development of the IMPACT platform. Seismic Therapeutic's leadership is led by co-founder and CEO Jo Viney, Ph.D., with a team described as expert drug hunters, technology integrators, and company builders. The company's approach leverages machine learning to address central challenges in biologics discovery and development, aiming to create better and faster pathways to bring new medicines for patients with autoimmune diseases to market.

Who has invested in Seismic Therapeutic?

16 investors have backed Seismic Therapeutic across its funding rounds, including Lightspeed Venture Partners, GV, Polaris Partners, Samsara BioCapital, Boxer Capital and Timothy A. Springer.

Lead investors include Bessemer Venture Partners and Lightspeed Venture Partners.


Seismic Therapeutic Investors

Investors in Seismic Therapeutic by funding rounds participated
InvestorHQRoundsRoleFirst check
Boxer CapitalUnited StatesOrlando, FL2ParticipantFeb 2022
GVUnited StatesSan Francisco, CA2ParticipantFeb 2022
Polaris PartnersUnited StatesBoston, MA2ParticipantFeb 2022
Lightspeed Venture PartnersUnited StatesSan Francisco, CA2LeadFeb 2022
Timothy A. SpringerUnited StatesUnited States2ParticipantFeb 2022
Samsara BioCapitalUnited StatesSan Francisco, CA2ParticipantFeb 2022
Amgen VenturesUnited StatesSan Francisco, CA1ParticipantDec 2023
AbrdnUnited KingdomChelmsford1ParticipantSep 2024
The Pags GroupUnited StatesBoston, MA1ParticipantSep 2024
GC&H InvestmentsUnited StatesSan Francisco, CA1ParticipantDec 2023
Alexandria Venture InvestmentsUnited StatesLos Angeles, CA1ParticipantDec 2023
SymBiosisUnited StatesBentonville, AR1ParticipantSep 2024
Other People's CapitalUnited StatesNew York City, NY1ParticipantFeb 2022

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Seismic Therapeutic Competitors

Seismic Therapeutic competitors include listed companies like Sol-Gel Technologies and Journey Medical, and private ones like CarbonSilicon AI, Recludix Pharma, Culture Biosciences and Activ Surgical.

Public and private companies comparable to Seismic Therapeutic
CompanyHQStatusRevenueEBITDAValuationRevenue Multiple
CarbonSilicon AIChinaHangzhouPrivate--$176M-
Recludix PharmaUnited StatesSan Diego, CAPrivate--$204M-
Culture BiosciencesUnited StatesSan Francisco, CAPrivate--$220M-
Activ SurgicalUnited StatesBoston, MAPrivate--$225M-
Sol-Gel TechnologiesChinaChinaPublicly listed$19M($7M)$211M27.5x
Journey MedicalUnited StatesUnited StatesPublicly listed$62M($4M)$208M2.7x

Seismic Therapeutic Public Comps

Seismic Therapeutic is still privately-owned, but its public comps include Sol-Gel Technologies, Veraxa Biotech, Journey Medical, Abeja, Alector, Eledon Pharmaceuticals, PepGen, REPLOID Group, Expert.ai and Savior Lifetec.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
Sol-Gel Technologies$19M($7M)8.5x27.5x(22.1x)-
Veraxa Biotech$29K($79M)7313.2x-(2.6x)-
Journey Medical$62M($4M)3.4x2.7x(53.0x)24.2x
Abeja$23M$3M7.8x6.4x60.9x-
Alector$21M($133M)3.1x4.7x(0.5x)(0.5x)
Eledon Pharmaceuticals-($45M)--(3.7x)-
PepGen-($88M)--(1.2x)-
REPLOID Group$44M$15M5.1x-15.0x-

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Common questions about Seismic Therapeutic

When was Seismic Therapeutic founded?Seismic Therapeutic was founded in 2020.
Where is Seismic Therapeutic headquartered?Seismic Therapeutic is headquartered in Boston, MA, United States.
Is Seismic Therapeutic publicly listed?No, Seismic Therapeutic is a private, VC-backed company.
What is Seismic Therapeutic's valuation?Seismic Therapeutic was last valued at $210M in its Series A in February 2022.
How much funding has Seismic Therapeutic raised?Seismic Therapeutic has raised $247M across 3 funding rounds.
What was Seismic Therapeutic's last funding round?Seismic Therapeutic's last funding round was a $25M Series B in September 2024.
Who are Seismic Therapeutic's investors?Seismic Therapeutic's investors include Boxer Capital, GV, Polaris Partners, Lightspeed Venture Partners, Timothy A. Springer, Samsara BioCapital, Amgen Ventures, Abrdn, The Pags Group, GC&H Investments and 6 others.
Which companies are comparable to Seismic Therapeutic?Companies comparable to Seismic Therapeutic include CarbonSilicon AI, Recludix Pharma, Culture Biosciences, Activ Surgical, Sol-Gel Technologies and Journey Medical.

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