Peptilogics Valuation, Funding & Investors

Peptilogics is valued at $420M as of October 2025.

Last Peptilogics valuation

$420M

Series B · Oct 2025

Last Peptilogics funding round

$78M

Series B · Oct 2025

Cumulative funding Peptilogics raised

$119M

across 5 funding rounds

Key investors in Peptilogics

  • Founders Fund
  • Presight Capital
  • Peter Thiel
  • Innovation Works
  • Narya Capital
  • Beyond Ventures

Peptilogics Overview

About Peptilogics

Peptilogics is a Salt Lake City-headquartered clinical-stage biotech developing peptide therapeutics via its IPC platform. This computational system explores novel chemical spaces to design scalable, biologically active peptides. Lead candidate PLG0206 targets prosthetic joint infections, holding FDA Orphan Drug and QIDP designations. The firm advances additional programs in anti-infectives and partnered oncology indications.


Founded

2013

HQ

United StatesPittsburgh, PA

Status

Privately held

Customer focus

B2B

Revenue model

Licensing, Subscription

Valuation

$420M (Oct 2025)

Peptilogics Valuation

Peptilogics is currently valued at $420M, based on its Series B in October 2025.

The $78M round was led by Founders Fund, Presight Capital and Thiel Bio, with participation from Beyond Ventures, AMR Action Fund and Narya Capital.

Peptilogics valuation by funding round

Peptilogics valuation by funding round
DateStageValuation
Oct 2025Series B$420M

Peptilogics Funding History

Peptilogics has raised a total of $119M across 5 funding rounds.

Peptilogics' first fundraising round was a $400K seed round in January 2016. The most recent completed round was a $78M Series B in October 2025.

Peptilogics funding rounds

Peptilogics funding rounds
DateStageInvestorsRaisedValuationDeal Summary
Oct 2025Series BFounders Fund (lead); Presight Capital (lead); Thiel Bio (lead); Beyond Ventures; AMR Action Fund; Narya Capital$78M$420MPeptilogics, founded in 2020 and headquartered in San Francisco with operations in Pittsburgh, develops macrocyclic peptide therapeutics targeting challenging drug targets, particularly zaloganan for prosthetic joint infection (PJI) caused by antibiotic-resistant bacteria. The company raised $78 million in a Series B2 round on or around October 16, 2025, led by Presight Capital, Thiel Bio, and Founders Fund, with participation from AMR Action Fund, Narya Capital, and Beyond Ventures. This brought total equity funding to approximately $120 million, plus CARB-X grants. The $420 million valuation reflects strong investor confidence in Peptilogics' platform and pipeline. Zaloganan has QIDP, Orphan Drug, and Fast Track designations from the FDA. The funding will advance a Phase 2/3 pivotal trial starting December 2025 with 240 patients, measuring clinical failure rates and health economics like hospitalization duration. Although pre-revenue, Peptilogics employs 60-100 people and plans to accelerate product development, expand market reach, scale teams, and strengthen biotech positioning. Investors have backed successes like AbCellera and Kriya Therapeutics. The round aligns with biotech trends in innovative anti-infectives amid rising PJI burdens on healthcare systems.
Dec 2020Series BPresight Capital (lead); Peter Thiel; Founders Fund$35M-Peptilogics, a Pittsburgh-based biotech company founded around 2016-2017, develops a proprietary computational peptide drug design and discovery platform focused on macrocyclic peptides for challenging drug targets. The company closed a $35.4 million Series B financing on December 21, 2020, led by Presight Capital, with participation from Founders Fund and existing investor Peter Thiel. This round advanced the company's efforts in scalable rational peptide design, challenging traditional drug discovery by starting with a target drug profile and engineering novel molecules. Presight Capital, managed by Christian Angermayer and Fabian Hansen, highlighted Peptilogics' potential to lead in peptide therapeutics, positioning it among their investments in frontier biotech like AbCellera and Compass Pathways. Peter Thiel, known for early stakes in PayPal, Palantir, and biotech firms, continued support as an individual investor. The company, now headquartered in San Francisco with 60-100 employees, competes in the biotech space emphasizing technology-driven peptide innovation against players like Benchling and insitro.
Jun 2019Pre-seedInnovation Works; Tachyon Ventures$100K--
Sep 2017Series APeter Thiel; BlueTree Venture Fund; Stefan Roever$6M-Peptilogics is a Pittsburgh-based pre-clinical stage biotechnology company developing peptide therapeutics to treat multidrug-resistant bacterial infections using its proprietary eCAP platform. The company raised $5.5 million in Series A funding on September 29, 2017, from investors including Peter Thiel, Stefan Roever, and BlueTree Ventures. The financing supports advancing its lead candidate toward an IND filing, following preclinical data demonstrating broad-spectrum efficacy against resistant bacteria and an encouraging toxicity profile. BlueTree Ventures highlighted the platform's in vivo efficacy and safety potential, addressing the unmet need in multidrug-resistant infections. Peptilogics appointed Sanjay Kakkar, M.D., as CEO to lead the effort. The round positions the company to rapidly establish proof of concept for its peptide-based anti-infectives.
Jan 2016Seed-$400K--

Who has invested in Peptilogics?

11 investors have backed Peptilogics across its funding rounds, including Founders Fund, Presight Capital, Peter Thiel, Innovation Works, Narya Capital and Beyond Ventures.

Lead investors include Founders Fund, Presight Capital and Thiel Bio.


Peptilogics Investors

Investors in Peptilogics by funding rounds participated
InvestorHQRoundsRoleFirst check
Peter ThielUnited StatesSan Francisco, CA2ParticipantSep 2017
Founders FundUnited StatesSan Francisco, CA2LeadDec 2020
Presight CapitalUnited StatesLos Angeles, CA2LeadDec 2020
Innovation WorksUnited StatesPittsburgh, PA1ParticipantJun 2019
Thiel Bio--1LeadOct 2025
BlueTree Venture FundUnited StatesPittsburgh, PA1ParticipantSep 2017
Tachyon VenturesUnited StatesLos Angeles, CA1ParticipantJun 2019
Beyond VenturesHong KongHong Kong1ParticipantOct 2025
AMR Action FundUnited StatesBoston, MA1ParticipantOct 2025

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Peptilogics Competitors

Peptilogics competitors include listed companies like Ropeok Technology Group and Beijing Hanyi Innovation, and private ones like DualEntry, Jada Ai, Akur8 and AssetWatch.

Public and private companies comparable to Peptilogics
CompanyHQStatusRevenueEBITDAValuationRevenue Multiple
DualEntryUnited StatesNew York City, NYPrivate--$415M-
Jada AiUnited StatesWilmington, DEPrivate--$415M-
Akur8FranceParisPrivate--$432M-
AssetWatchUnited StatesColumbus, OHPrivate--$437M-
Ropeok Technology GroupChinaChinaPublicly listed$23M($28M)$396M-
Beijing Hanyi InnovationChinaChinaPublicly listed$28M$5M$493M13.9x

Peptilogics Public Comps

Peptilogics is still privately-owned, but its public comps include C4 Therapeutics, Atea Pharmaceuticals, Renata, Winner Technology, Editas Medicine, Zhejiang Shouxiangu, ARS Pharmaceuticals, Artiva Biotherapeutics, Nika Pharmaceuticals and Prothena Corp..

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
C4 Therapeutics$36M($113M)6.2x7.8x(2.0x)-
Atea Pharmaceuticals-($180M)--(1.1x)(1.1x)
Renata$348M$48M1.6x1.5x11.9x-
Winner Technology$46M($7M)9.0x-(60.9x)-
Editas Medicine$41M($157M)5.5x7.3x(1.4x)(1.9x)
Zhejiang Shouxiangu$95M$30M3.7x3.8x11.7x-
ARS Pharmaceuticals$84M($179M)4.3x3.1x(2.0x)-
Artiva Biotherapeutics-($87M)--(0.8x)-

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Common questions about Peptilogics

When was Peptilogics founded?Peptilogics was founded in 2013.
Where is Peptilogics headquartered?Peptilogics is headquartered in Pittsburgh, PA, United States.
Is Peptilogics publicly listed?No, Peptilogics is a private, VC-backed company.
What is Peptilogics' valuation?Peptilogics was last valued at $420M in its Series B in October 2025.
How much funding has Peptilogics raised?Peptilogics has raised $119M across 5 funding rounds.
What was Peptilogics' last funding round?Peptilogics' last funding round was a $78M Series B in October 2025, led by Founders Fund, Presight Capital and Thiel Bio.
Who are Peptilogics' investors?Peptilogics' investors include Peter Thiel, Founders Fund, Presight Capital, Innovation Works, Thiel Bio, BlueTree Venture Fund, Tachyon Ventures, Beyond Ventures, AMR Action Fund, Stefan Roever and 1 other.
Which companies are comparable to Peptilogics?Companies comparable to Peptilogics include DualEntry, Jada Ai, Akur8, AssetWatch, Ropeok Technology Group and Beijing Hanyi Innovation.

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