Expedition Therapeutics Valuation, Funding & Investors

MiMedx Group Inc develops and markets regenerative biomaterial products and bioimplants made from the human amniotic membrane, birth tissues, and human skin & bone. Its products are targeted towards the wound-care, burn, surgical, sports medicine, and orthopedics markets. MiMedx's key products are allografts processed from amniotic tissue, which include EpiFix for external use and AmnioFix for internal use. AmnioCord, AmnioFill, EpiBurn, and EpiCord are some of its other products. Also, it sells allografts for ophthalmic surgery and dental applications through licenses to third parties.

Ring Therapeutics is a biotechnology company developing Anellovector gene therapies derived from human commensal viruses for redosable and targeted treatments. Backed by Flagship Pioneering and based in Cambridge, Massachusetts, it advances platforms beyond traditional gene replacement for diseases like liver disorders and muscle wasting. Founded in 2022, Ring Therapeutics pioneers viral vectors for immunology and oncology applications.

SmartCella is a Milan-based biotechnology company advancing cell therapy delivery for cardiac regeneration. Its SmartCella device enables precise intracoronary injection of stem cells, drugs, and RNA therapeutics during procedures. Tested in preclinical models for heart failure and myocardial infarction, it partners with clinics in Italy and the EU. Founded in 2016, SmartCella focuses on interventional cardiology applications.

Strand Therapeutics is a Cambridge-headquartered biotechnology firm founded in 2017 that engineers programmable mRNA medicines using synthetic biology principles. The platform deploys logic circuits within cells to detect tumor-specific signals and produce cancer-fighting proteins on demand, such as cytokines for immunotherapy. Their lead candidates target solid tumors including glioblastoma and head-and-neck cancers through intravenous administration. Strand Therapeutics collaborates with academic institutions like MIT and has progressed multiple programs into preclinical testing for oncology applications.

Ocumension Therapeutics is an ophthalmic pharmaceutical platform company identifying, developing, and commercializing ophthalmic therapies. It provides a pharmaceutical total solution to address unmet ophthalmic medical needs in China. Its product candidates include OT-401 (YUTIQ), OT-101, OT-301 (NCX 470), OT-1001 (ZERVIATE), OT-502 (DEXYCU), OT-202, OT-503 (NCX 4251), OT-701, Ou Qin, Brimonidine tartrate eye drop, 0.5% moxifloxacin eye drop, OT-601-C, OT-302, OT-1301, T-1601, and OT-1602.

Umoja Biopharma engineers in vivo CAR T-cell therapies that reprogram patients' T cells to attack solid tumors and hematological malignancies resistant to existing treatments. Seattle-headquartered, the company advances its AlloVector platform for localized immune cell activation without ex vivo manipulation. Partnerships with Biogen and Takeda support clinical progression in oncology pipelines targeting glioblastoma and other cancers.

Shoreline Biosciences is a biotechnology company developing allogeneic, off-the-shelf cellular immunotherapies for cancer, using induced pluripotent stem cells (iPSCs) to derive natural killer cell and macrophage therapies for solid tumors and blood cancers. Founded in 2020 by Kleanthis Xanthopoulos and based in San Diego, the company builds smart manufacturing capabilities to support its pipeline and holds strategic partnerships with Kite, a Gilead company, and BeiGene for cell therapy development.

Ollin Biosciences is an Austin, Texas-based clinical-stage biopharmaceutical company that acquires and develops bispecific antibody therapies for vision-threatening eye diseases rather than pursuing in-house drug discovery. Its lead candidate, OLN324, is a VEGF/Ang2 bispecific antibody licensed from China's Innovent Biologics that is advancing toward Phase 3 trials for diabetic macular edema and wet age-related macular degeneration. A second program, OLN102, licensed from VelaVigo, is a TSHR/IGF-1R bispecific antibody in development for thyroid eye disease and Graves' disease.

Yantai Lannacheng Biotechnology is a Yantai-based biotechnology company that develops class I integrated platforms for diagnosis and therapy using novel nuclear radiopharmaceuticals targeting tumors. The firm advances research in targeted radionuclide therapies and diagnostic agents for oncology applications. Its platform supports development of precision medicines for cancer treatment in China.

BenevolentAI is a London-headquartered clinical-stage company using artificial intelligence for drug discovery, listed on Euronext Amsterdam under BAI. Its platform supports 13 named programs and over 10 exploratory ones, with collaborations including AstraZeneca on respiratory and cardiovascular diseases. Facilities in Cambridge and New York enable wet-lab validation of AI-generated candidates.

Endeavor BioMedicines is a clinical-stage biopharmaceutical company developing therapies for idiopathic pulmonary fibrosis. Solana Beach-headquartered in California, it advances its lead candidate, ENDEAVOR-101, a TNIK inhibitor in Phase 2 trials targeting fibrotic pathways. The firm raised $115 million in Series A financing from investors like Alpha Wave Global and Sanofi Ventures. Founded in 2018 by veterans from Gilead and Roche, Endeavor focuses on precision medicine for rare lung diseases affecting over 100,000 patients in the US.

Galvanize Therapeutics is a Boston-headquartered medical device company developing pulsed field ablation platforms for respiratory, cardiac, and oncology applications. Its portfolio features the Galaxy system for bronchoscopic lung volume reduction in chronic obstructive pulmonary disease patients and the Pulse Field Ablation platform for atrial fibrillation. The company targets solid tumors through non-thermal tissue ablation and holds FDA Breakthrough Device Designation for its cardiac rhythm management tools. Backed by Apple Tree Partners since its 2022 inception, Galvanize Therapeutics advances therapies across U.S. clinical sites and international partnerships.

SetPoint Medical is a Los Angeles-based medical device company developing the SetPoint System, an implantable vagus nerve stimulator for treating rheumatoid arthritis in adults unresponsive to conventional therapies. The wireless device modulates inflammation via bioelectronic signals. SetPoint Medical advances clinical trials in the United States and Europe for autoimmune indications.

Neurogene Inc is a clinical-stage biotechnology company committed to overcoming the limitations of neurological diseases into treatable conditions, by harnessing its proprietary transgene regulation technology, EXACTTM (Expression Attenuation via Construct Tuning). It is building a differentiated product portfolio of genetic medicines for rare neurological diseases with high unmet needs. The drug candidates in the company's product pipeline include NGN-401, which is in development for the treatment of Rett syndrome, using its EXACT platform, and NGN-101, a non-EXACT, conventional gene therapy development candidate for the treatment of CLN5 Batten disease, designed to deliver the CLN5 gene and packaged in an AAV9 capsid.

Lepu Bio is a Beijing-headquartered biopharmaceutical company that develops oncology therapeutics, including antibody-drug conjugates like the HER2-targeting LPB-001 in phase 1 trials, oncolytic viruses such as LPB-R1, a PD-1/VEGF bispecific antibody in phase 2, and CAR-T cell therapies. Part of the Lepu Medical group, it maintains R&D centers in Beijing and San Diego. The company listed on the Shanghai STAR Market in August 2023 under stock code 688008, raising over 1 billion RMB. Its pipeline spans 10 clinical-stage candidates targeting solid tumors like breast, lung, and gastric cancers.

OmniAb Inc offers therapeutic antibody discovery technologies. It focuses on enabling the rapid development of therapeutics by pushing the frontiers of drug discovery technologies. Its technology platform is designed to enable the efficient discovery of high-quality, fully human antibodies for a wide range of diseases. The heart of the OmniAb technology platform is the Biological Intelligence of its proprietary transgenic animals, including OmniRat, OmniMouse, and OmniChicken, that have been genetically modified to generate antibodies with human sequences which are naturally optimized through in vivo affinity maturation.

MAXVAX is a China-based biotechnology firm developing vaccines for infectious diseases. Headquartered in Shanghai, the company advances novel platforms for HPV, influenza, and hand-foot-mouth disease vaccines, conducting clinical trials in partnership with Chinese CDC institutes.

Direct Biologics is an Austin-based developer and cGMP manufacturer of regenerative biologics derived from human amniotic tissue and umbilical cord sources. The company produces products like EmD (extracellular microenvironment dressing) for wound care and DBM (decellularized bone matrix) for orthopedic applications. As a leader in the biologics space, Direct Biologics supplies hospitals, surgery centers, and clinics with shelf-stable allografts that promote tissue repair and reduce inflammation. Operating FDA-registered facilities, the firm adheres to stringent quality standards for clinical use in sports medicine, spine surgery, and general orthopedics across the United States.