Blueprint Medicines Acquisition, Valuation, Funding & Investors

Blueprint Medicines was acquired by Sanofi for $9.5B in June 2025, a 17.0x multiple on $560M of revenue.

Blueprint Medicines acquisition price

$9.5B

Acquired by Sanofi · Jun 2025

Blueprint Medicines revenue at acquisition

$560M

Last twelve months · Jun 2025

Blueprint Medicines revenue multiple at acquisition

17.0x

EV/Revenue · Jun 2025

Cumulative funding Blueprint Medicines raised

$115M

across 3 funding rounds

Blueprint Medicines Overview

About Blueprint Medicines

Blueprint Medicines is a Cambridge, Massachusetts-headquartered biopharmaceutical company that develops kinase-targeted therapies for genomically defined cancers and rare blood disorders. Founded in 2011 and listed on Nasdaq as BPMC, its approved products include Ayvakit for systemic mastocytosis and GIST with PDGFRA exon 18 mutations, and Ayvakyt for pediatric applications. The pipeline features BLU-701 for EGFR-driven lung cancers and BLU-945, advancing precision oncology through mutant-selective inhibitors.


Founded

2011

HQ

United StatesCambridge, MA

Status

Acquired

Customer focus

B2B

Revenue model

Product sales

Revenue

$560M (Jun 2025)

Valuation

$9.5B (acquired Jun 2025)

Blueprint Medicines Acquisition

Blueprint Medicines was acquired by Sanofi for $9.5B on 2 June 2025.

The acquisition price implies a 17.0x revenue multiple on $560M of revenue.

Before the acquisition Blueprint Medicines had raised $115M across 3 funding rounds.

Sanofi agreed to acquire Blueprint Medicines Corporation, a US-based biopharmaceutical company specializing in systemic mastocytosis (SM) and other KIT-driven diseases, in a transaction announced June 2, 2025, and completed July 18, 2025. Under the deal terms, Sanofi paid $129.00 per share in cash, representing an equity value of approximately $9.1 billion, with Blueprint shareholders also receiving contingent value rights (CVRs) entitling them to potential milestone payments of up to $6 per CVR tied to the development and regulatory milestones of BLU-808, bringing the total transaction value to approximately $9.5 billion on a fully diluted basis. The acquisition was completed via merger of a Sanofi subsidiary into Blueprint under Delaware law Section 251(h), with Blueprint becoming a wholly owned indirect subsidiary of Sanofi. Blueprint's primary asset is Ayvakit (avapritinib), the only FDA and EU-approved medicine for advanced and indolent systemic mastocytosis, which generated approximately $150 million in first-quarter 2025 revenue and was on a trajectory toward $1 billion in annual sales. The company's pipeline includes elenestinib, in late-stage development for systemic mastocytosis, alongside other early-stage KIT-driven disease candidates. Sanofi financed the transaction through a combination of cash on hand and commercial paper issuances, with no financing condition attached to the tender offer that expired July 17, 2025. The acquisition immediately accretive to gross margin and is accretive to business operating income and EPS after 2026, with no significant impact on Sanofi's 2025 financial guidance. The strategic rationale centered on expanding Sanofi's immunology portfolio and rare disease capabilities while leveraging Blueprint's established relationships with allergists, dermatologists, and immunologists to advance Sanofi's growing immunology pipeline. Blueprint's stock ceased trading on the NASDAQ Global Select Stock Market on July 18, 2025, following completion of the merger.

Blueprint Medicines acquisition details
AcquirerDateTypePriceEV/Revenue
2 Jun 2025Strategic M&A$9.5B17.0x

Sources: sanofi.com

Blueprint Medicines Funding History

Blueprint Medicines has raised a total of $115M across 3 funding rounds.

Blueprint Medicines' first fundraising round was a $40M Series A in April 2011. The most recent completed round was a $50M Series C in November 2014.

Blueprint Medicines funding rounds

Blueprint Medicines funding rounds
DateStageInvestorsRaisedDeal Summary
Nov 2014Series CPartner Fund Management (lead); Sabby Capital; Wellington Management; Nextech Invest; Redmile Group; Casdin Capital; Third Rock Ventures; Cowen Group; RA Capital Management; Tavistock Life Sciences; Perceptive Advisors; Fidelity Biosciences$50MBlueprint Medicines completed a $50 million Series C financing in November 2014. The round was led by Partner Fund Management and included new investors Wellington Management Company, RA Capital, Tavistock Life Sciences, Perceptive Advisors, Sabby Capital, Cowen Investments and Redmile Group, alongside existing shareholders Biotechnology Value Fund, Casdin Capital, Fidelity Biosciences, Nextech Invest and Third Rock Ventures. The proceeds were earmarked to carry two lead candidates into clinical trials during 2015 and to fund continued development of the company's kinase discovery platform and pipeline. Those candidates were BLU-285, a selective KIT inhibitor aimed at systemic mastocytosis and gastrointestinal stromal tumours, and BLU-554, an FGFR4 inhibitor for hepatocellular carcinoma. The company was founded in 2011 and is based in Cambridge, Massachusetts, where it develops highly selective kinase inhibitors for genomically defined cancers using a proprietary compound library and target discovery engine. Jeffrey Albers was chief executive at the time of the financing. The Series C was the last private round before Blueprint's NASDAQ listing in April 2015.
Jan 2014Series BNextech Invest (lead); Casdin Capital; Third Rock Ventures; Biotechnology Value Fund; F-Prime; Fidelity Biosciences$25MBlueprint Medicines, founded in 2011 by the developers of cancer drug Gleevec (imatinib) and Third Rock Ventures, develops targeted cancer therapeutics using a novel target discovery engine and proprietary compound library to create highly selective kinase inhibitors for genomically defined diseases. The company focuses on patient-defined medicines, including selective inhibitors for KIT D816V mutation in systemic mastocytosis and gastrointestinal stromal tumors, as well as isoform-selective FGFR4 inhibitors for hepatocellular carcinoma and other tumors. In January 2014, Nextech Invest led Blueprint Medicines' $25 million Series B financing round, with participation from Biotechnology Value Fund, Casdin Capital, Fidelity Biosciences, Third Rock Ventures, and other undisclosed investors. The funds supported advancement of the pipeline toward clinical trials expected to start in 2015 for KIT and FGFR4 programs, aiming for proof-of-concept in well-defined patient populations, initially as single agents in late-stage or resistant cases and in combinations. Prior to Series B, Blueprint raised $40 million in a Series A round in April 2011. Following Series B, in November 2014, the company secured a $50 million mezzanine Series C financing led by Partner Fund Management, with new investors like Wellington Management, RA Capital, and participation from existing shareholders including Biotechnology Value Fund, Casdin Capital, Fidelity Biosciences, Nextech Invest, and Third Rock Ventures. By April 2015 IPO, total financings reached $260 million, with NASDAQ debut under BPMC at a market cap of $465 million.
Apr 2011Series AThird Rock Ventures (lead)$40MBlueprint Medicines was launched in April 2011 with a $40 million Series A financing from Third Rock Ventures, at the time the largest Series A the firm had committed to a new company. The round funded the company from its first day of operations, before it had an established drug pipeline, on the strength of its founding science and team. The founders were Chris Varma, who became president and chief executive, together with Nicholas Lydon, Brian Druker and David Armistead; Lydon and Druker had both been central to the development of Gleevec (imatinib). Mark Levin and Alexis Borisy of Third Rock joined the board. The company is based in Cambridge, Massachusetts and set out to build kinase-targeted, patient-defined cancer medicines using a proprietary compound library and a target discovery engine it called the Insights-to-Validation platform. Blueprint planned to hire roughly sixteen chemists, biochemists and bioinformaticians in its first year. The Series A was followed by a $25 million Series B in January 2014 and a $50 million Series C in November 2014 before the company listed on NASDAQ in April 2015.

Who has invested in Blueprint Medicines?

14 investors have backed Blueprint Medicines across its funding rounds, including Third Rock Ventures, Casdin Capital, Nextech Invest, Fidelity Biosciences, F-Prime and RA Capital Management.

Lead investors include Partner Fund Management, Nextech Invest and Third Rock Ventures.


Blueprint Medicines Investors

Investors in Blueprint Medicines by funding rounds participated
InvestorHQRoundsRoleFirst check
Third Rock VenturesUnited StatesBoston, MA3LeadApr 2011
Nextech InvestSwitzerlandZurich2LeadJan 2014
Casdin CapitalUnited StatesNew York City, NY2ParticipantJan 2014
Fidelity BiosciencesUnited StatesBoston, MA2ParticipantJan 2014
Sabby CapitalUnited StatesUpper Saddle River, NJ1ParticipantNov 2014
Wellington ManagementUnited StatesBoston, MA1ParticipantNov 2014
Redmile GroupUnited StatesSan Francisco, CA1ParticipantNov 2014
Biotechnology Value FundUnited StatesSan Francisco, CA1ParticipantJan 2014
F-PrimeUnited StatesUnited States1ParticipantJan 2014
Partner Fund ManagementUnited StatesUnited States1LeadNov 2014
Cowen GroupUnited StatesUnited States1ParticipantNov 2014
RA Capital ManagementUnited StatesBoston, MA1ParticipantNov 2014

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Acquisitions by Blueprint Medicines

Blueprint Medicines has acquired 1 company to date.

Last acquisition by Blueprint Medicines was on November 29th 2021. Blueprint Medicines acquired Lengo Therapeutics for $250M.


Latest Acquisitions by Blueprint Medicines

Lengo Therapeutics
Description
Lengo Therapeutics is a biopharmaceutical company in San Francisco focused on oncology drug discovery targeting undruggable cancer mutations. The firm develops small-molecule inhibitors for KRAS and other driver mutations previously overlooked by standard therapies. Lengo Therapeutics collaborates with academic institutions like Stanford University and has advanced two candidates into preclinical trials. Founded in 2020, it operates a lab in the Bay Area with expertise in precision medicine.
HQ CountryUnited States
HQ City
San Diego, CA
Deal Date29 Nov 2021
Valuation$250M
EV/Revenue
EV/EBITDA

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Blueprint Medicines Competitors

Blueprint Medicines competitors include listed companies like Lupin, Madrigal Pharmaceuticals, TG Therapeutics and ImmunityBio, and private ones like Intas Pharmaceuticals and Biosplice Therapeutics.

Public and private companies comparable to Blueprint Medicines
CompanyHQStatusRevenueEBITDAValuationRevenue Multiple
LupinIndiaIndiaPublicly listed$2.9B$885M$9.7B3.0x
Madrigal PharmaceuticalsUnited StatesUnited StatesPublicly listed$958M($302M)$9.3B5.8x
TG TherapeuticsUnited StatesUnited StatesPublicly listed$616M$134M$9.2B10.3x
ImmunityBioUnited StatesUnited StatesPublicly listed$113M($226M)$9.2B45.7x
Intas PharmaceuticalsIndiaAhmedabadPrivate$2B-$8.5B-
Biosplice TherapeuticsUnited StatesSan Diego, CAPrivate--$12B-

Blueprint Medicines Public Comps

Blueprint Medicines is no longer listed, but its public comps include Lupin, Madrigal Pharmaceuticals, TG Therapeutics, ImmunityBio, Spyre Therapeutics, Haisco Pharmaceutical, Krystal Biotech, Vaxcyte, Akeso and Fosun Pharma.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
Lupin$2.9B$885M3.2x3.0x10.7x11.4x
Madrigal Pharmaceuticals$958M($302M)9.1x5.8x(28.7x)-
TG Therapeutics$616M$134M15.2x10.3x69.7x43.7x
ImmunityBio$113M($226M)84.8x45.7x(42.5x)-
Spyre Therapeutics-($180M)--(49.6x)(31.6x)
Haisco Pharmaceutical$658M$84M15.2x10.1x119.4x35.6x
Krystal Biotech$389M$168M20.6x16.6x47.7x32.4x
Vaxcyte-($870M)--(10.4x)(7.4x)

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Common questions about Blueprint Medicines

When was Blueprint Medicines founded?Blueprint Medicines was founded in 2011.
Where is Blueprint Medicines headquartered?Blueprint Medicines is headquartered in Cambridge, MA, United States.
Is Blueprint Medicines publicly listed?No, Blueprint Medicines was acquired by Sanofi in June 2025.
Who acquired Blueprint Medicines?Blueprint Medicines was acquired by Sanofi in June 2025.
How much was Blueprint Medicines acquired for?Blueprint Medicines was acquired for $9.5B in June 2025, a 17.0x revenue multiple.
How much funding has Blueprint Medicines raised?Blueprint Medicines has raised $115M across 3 funding rounds.
What was Blueprint Medicines' last funding round?Blueprint Medicines' last funding round was a $50M Series C in November 2014, led by Partner Fund Management.
Who are Blueprint Medicines' investors?Blueprint Medicines' investors include Third Rock Ventures, Nextech Invest, Casdin Capital, Fidelity Biosciences, Sabby Capital, Wellington Management, Redmile Group, Biotechnology Value Fund, F-Prime, Partner Fund Management and 4 others.
Which companies are comparable to Blueprint Medicines?Companies comparable to Blueprint Medicines include Lupin, Madrigal Pharmaceuticals, TG Therapeutics, ImmunityBio, Intas Pharmaceuticals and Biosplice Therapeutics.
How many companies has Blueprint Medicines acquired?Blueprint Medicines has acquired 1 company, including Lengo Therapeutics.
What was the largest acquisition by Blueprint Medicines?The $250M acquisition of Lengo Therapeutics in November 2021 is the largest acquisition Blueprint Medicines has made to date.

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