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- Tizona Therapeutics
Tizona Therapeutics Valuation, Funding & Investors
Tizona Therapeutics is valued at $601M as of July 2020.
Last Tizona Therapeutics valuation
$601M
Strategic investment · Jul 2020
Last Tizona Therapeutics funding round
$300M
Strategic investment · Jul 2020
Cumulative funding Tizona Therapeutics raised
$370M
across 3 funding rounds
Key investors in Tizona Therapeutics
InterWest Partners
MPM Capital
Amgen Ventures
Astellas Venture Management
Canaan Partners
Lightstone Ventures
About Tizona Therapeutics
Tizona Therapeutics advances immuno-oncology therapies targeting regulatory T cells to overcome tumor immunosuppression. Collaborating closely with its scientific founders, the company investigates Treg roles across various cancer types to inform precision treatments. South San Francisco-headquartered, Tizona differentiates through data-driven insights into tumor microenvironments.
Founded
2014
HQ
Website
Status
Privately held
Customer focus
B2B
Revenue model
Licensing
Valuation
$601M (Jul 2020)
Sectors
Tizona Therapeutics Valuation
Tizona Therapeutics is currently valued at $601M, based on its strategic investment round in July 2020.
The $300M round was led by Gilead Sciences.
Tizona Therapeutics' valuation has grown 5.4x from $112M at its Series A in January 2016 to $601M in July 2020, across 2 priced rounds.
Tizona Therapeutics valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Jul 2020 | Strategic investment | $601M |
| Jan 2016 | Series A | $112M |
Tizona Therapeutics Funding History
Tizona Therapeutics has raised a total of $370M across 3 funding rounds.
Tizona Therapeutics' first fundraising round was a $27M Series A in January 2016. The most recent completed round was a $300M strategic investment round in July 2020.
Tizona Therapeutics funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Jul 2020 | Strategic investment | Gilead Sciences (lead) | $300M | $601M | Tizona Therapeutics is a privately held biopharmaceutical company based in South San Francisco developing first-in-class cancer immunotherapies. The company's lead program is TTX-080, an investigational antibody candidate designed to target HLA-G, a novel immune checkpoint expressed across multiple tumor types. Tizona discovered TTX-080 and obtained FDA clearance for an investigational new drug application, with plans to initiate Phase I clinical trials in the third quarter of 2020 evaluating the candidate as both monotherapy and in combination therapy in patients with advanced cancers. In July 2020, Gilead Sciences invested $300 million to acquire a 49.9% equity interest in Tizona, with an exclusive option to purchase the remaining equity for up to an additional $1.25 billion including an option exercise fee and potential milestone payments. The option could be exercised following the readout of Phase 1b studies for TTX-080 or earlier at Gilead's discretion. Under the deal terms, Gilead would appoint two individuals to Tizona's Board of Directors upon closing, and would provide funding support for the company's ongoing research and development activities. Prior to the Gilead transaction, Tizona had partnered with AbbVie on TTX-030, an anti-CD39 antibody, which was required to be spun off into a separate entity as it was not subject to the Gilead agreement. |
| Mar 2016 | Series B | Abingworth (lead); Lightstone Ventures; Amgen Ventures; Canaan Partners; MPM Capital; Astellas Venture Management; InterWest Partners | $43M | - | Tizona Therapeutics completed a $43 million Series B financing round on March 8, 2016, co-led by Abingworth and Canaan Partners. The round included investments from Lightstone Ventures and existing Series A investors including MPM Capital, Amgen Ventures, Astellas Venture Management, and InterWest Partners. This brought the company's total financing to over $70 million across Series A and B rounds. Tizona is an immuno-oncology company focused on developing therapies that activate the body's immune system to fight cancer or prevent it from attacking healthy tissues in autoimmune diseases. The company's lead drug candidate is an anti-CCR4 monoclonal antibody designed to deplete regulatory T cells to induce antitumor activity, with clinical entry expected in 2017. The financing also supported advancement of Tizona's pipeline based on an immunosuppressive cytokine called IL-35. The company was founded by MPM Capital and is led by Pablo J. Cagnoni as President and Chief Executive Officer. |
| Jan 2016 | Series A | Amgen Ventures; MPM Capital; Astellas Venture Management; InterWest Partners | $27M | $112M | Tizona Therapeutics is a South San Francisco-based biotech company focused on immuno-oncology, developing first-in-class antibodies to modulate the immune system against cancer, including a CCR4-targeting antibody to deplete regulatory T cells and an IL-35 candidate, with plans for additional programs entering clinical trials annually. The company emerged from stealth in 2016 after securing funding across early rounds. Tizona's pipeline at the time emphasized novel mechanisms to counter tumor immunosuppression, positioning it in the competitive immuno-oncology field alongside efforts to release effector T cell brakes. A previously unannounced Series A round raised roughly $27 million from MPM Capital, Amgen Ventures, Astellas Venture Management, and InterWest Partners, matching the specified investors. This was followed closely by a Series B round on March 8, 2016, with a post-money valuation of $111.94 million. Tizona continued raising capital post-2016, including later involvement from Abingworth, Canaan, Lightstone Ventures, and AbbVie Ventures. By July 2020, Gilead Sciences invested $300 million for a 49.9% equity stake, with an option to acquire the remainder for up to $1.25 billion, reflecting strong validation of its pipeline like TTX-080, an anti-HLA-G antibody. Prior to closing, Tizona spun off TTX-030 (in alliance with AbbVie) into a separate entity. Overall funding reached $343 million across four rounds. |
Who has invested in Tizona Therapeutics?
8 investors have backed Tizona Therapeutics across its funding rounds, including InterWest Partners, MPM Capital, Amgen Ventures, Astellas Venture Management, Canaan Partners and Lightstone Ventures.
Lead investors include Gilead Sciences and Abingworth.
Tizona Therapeutics Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 2 | Participant | Jan 2016 | ||
| 2 | Participant | Jan 2016 | ||
| 2 | Participant | Jan 2016 | ||
| 2 | Participant | Jan 2016 | ||
| 1 | Participant | Mar 2016 | ||
| 1 | Lead | Jul 2020 | ||
This data is available for Pro users. Sign up to see all 8 Tizona Therapeutics investors. Start Free Trial | ||||
Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
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Start Free TrialTizona Therapeutics Competitors
Tizona Therapeutics competitors include listed companies like Bright Minds Biosciences and Alkaloid, and private ones like Elpiscience Biopharmaceuticals, Iambic, Ottimo Pharma and Terray Therapeutics.
| Company | HQ | Status | Revenue | EBITDA | Valuation |
|---|---|---|---|---|---|
| Private | - | - | $600M | ||
| Private | - | - | $600M | ||
| Private | - | - | $600M | ||
| Private | - | - | $600M | ||
| Publicly listed | - | ($10M) | $604M | ||
| Publicly listed | $391M | $62M | $605M |
Tizona Therapeutics Public Comps
Tizona Therapeutics is still privately-owned, but its public comps include Bright Minds Biosciences, Alkaloid, Allogene Therapeutics, Avalon Pharma, Cormedix, Scribe Therapeutics, Agomab Therapeutics, TTY Biopharm, CytomX Therapeutics and Shattuck Labs.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| - | ($10M) | - | - | (39.2x) | (10.0x) | |||
| $391M | $62M | 1.7x | - | 10.7x | - | |||
| - | ($197M) | - | 122.7x | (1.7x) | (1.7x) | |||
| $123M | $34M | 5.1x | 4.6x | 18.2x | 18.3x | |||
| $312M | $164M | 1.6x | 1.5x | 3.0x | - | |||
| $51M | ($21M) | 14.2x | - | (34.0x) | - | |||
| - | ($74M) | - | 975.9x | (4.2x) | (3.8x) | |||
| $203M | $72M | 2.9x | 2.8x | 8.3x | - | |||
This data is available for Pro users. Sign up to see all Tizona Therapeutics competitors and their valuation data. Start Free Trial | ||||||||
Common questions about Tizona Therapeutics
| When was Tizona Therapeutics founded? | Tizona Therapeutics was founded in 2014. |
| Where is Tizona Therapeutics headquartered? | Tizona Therapeutics is headquartered in San Francisco, CA, United States. |
| Is Tizona Therapeutics publicly listed? | No, Tizona Therapeutics is a private, VC-backed company. |
| What is Tizona Therapeutics' valuation? | Tizona Therapeutics was last valued at $601M in its strategic investment round in July 2020. |
| How much funding has Tizona Therapeutics raised? | Tizona Therapeutics has raised $370M across 3 funding rounds. |
| What was Tizona Therapeutics' last funding round? | Tizona Therapeutics' last funding round was a $300M strategic investment round in July 2020, led by Gilead Sciences. |
| Who are Tizona Therapeutics' investors? | Tizona Therapeutics' investors include Amgen Ventures, MPM Capital, Astellas Venture Management, InterWest Partners, Lightstone Ventures, Gilead Sciences, Canaan Partners and Abingworth. |
| Which companies are comparable to Tizona Therapeutics? | Companies comparable to Tizona Therapeutics include Elpiscience Biopharmaceuticals, Iambic, Ottimo Pharma, Terray Therapeutics, Bright Minds Biosciences and Alkaloid. |
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