Tizona Therapeutics Valuation, Funding & Investors

Tizona Therapeutics is valued at $601M as of July 2020.

Last Tizona Therapeutics valuation

$601M

Strategic investment · Jul 2020

Last Tizona Therapeutics funding round

$300M

Strategic investment · Jul 2020

Cumulative funding Tizona Therapeutics raised

$370M

across 3 funding rounds

Key investors in Tizona Therapeutics

  • InterWest Partners
  • MPM Capital
  • Amgen Ventures
  • Astellas Venture Management
  • Canaan Partners
  • Lightstone Ventures

Tizona Therapeutics Overview

About Tizona Therapeutics

Tizona Therapeutics advances immuno-oncology therapies targeting regulatory T cells to overcome tumor immunosuppression. Collaborating closely with its scientific founders, the company investigates Treg roles across various cancer types to inform precision treatments. South San Francisco-headquartered, Tizona differentiates through data-driven insights into tumor microenvironments.


Founded

2014

HQ

United StatesSan Francisco, CA

Status

Privately held

Customer focus

B2B

Revenue model

Licensing

Valuation

$601M (Jul 2020)

Tizona Therapeutics Valuation

Tizona Therapeutics is currently valued at $601M, based on its strategic investment round in July 2020.

The $300M round was led by Gilead Sciences.

Tizona Therapeutics' valuation has grown 5.4x from $112M at its Series A in January 2016 to $601M in July 2020, across 2 priced rounds.

Tizona Therapeutics valuation by funding round

Tizona Therapeutics valuation by funding round
DateStageValuation
Jul 2020Strategic investment$601M
Jan 2016Series A$112M

Tizona Therapeutics Funding History

Tizona Therapeutics has raised a total of $370M across 3 funding rounds.

Tizona Therapeutics' first fundraising round was a $27M Series A in January 2016. The most recent completed round was a $300M strategic investment round in July 2020.

Tizona Therapeutics funding rounds

Tizona Therapeutics funding rounds
DateStageInvestorsRaisedValuationDeal Summary
Jul 2020Strategic investmentGilead Sciences (lead)$300M$601MTizona Therapeutics is a privately held biopharmaceutical company based in South San Francisco developing first-in-class cancer immunotherapies. The company's lead program is TTX-080, an investigational antibody candidate designed to target HLA-G, a novel immune checkpoint expressed across multiple tumor types. Tizona discovered TTX-080 and obtained FDA clearance for an investigational new drug application, with plans to initiate Phase I clinical trials in the third quarter of 2020 evaluating the candidate as both monotherapy and in combination therapy in patients with advanced cancers. In July 2020, Gilead Sciences invested $300 million to acquire a 49.9% equity interest in Tizona, with an exclusive option to purchase the remaining equity for up to an additional $1.25 billion including an option exercise fee and potential milestone payments. The option could be exercised following the readout of Phase 1b studies for TTX-080 or earlier at Gilead's discretion. Under the deal terms, Gilead would appoint two individuals to Tizona's Board of Directors upon closing, and would provide funding support for the company's ongoing research and development activities. Prior to the Gilead transaction, Tizona had partnered with AbbVie on TTX-030, an anti-CD39 antibody, which was required to be spun off into a separate entity as it was not subject to the Gilead agreement.
Mar 2016Series BAbingworth (lead); Lightstone Ventures; Amgen Ventures; Canaan Partners; MPM Capital; Astellas Venture Management; InterWest Partners$43M-Tizona Therapeutics completed a $43 million Series B financing round on March 8, 2016, co-led by Abingworth and Canaan Partners. The round included investments from Lightstone Ventures and existing Series A investors including MPM Capital, Amgen Ventures, Astellas Venture Management, and InterWest Partners. This brought the company's total financing to over $70 million across Series A and B rounds. Tizona is an immuno-oncology company focused on developing therapies that activate the body's immune system to fight cancer or prevent it from attacking healthy tissues in autoimmune diseases. The company's lead drug candidate is an anti-CCR4 monoclonal antibody designed to deplete regulatory T cells to induce antitumor activity, with clinical entry expected in 2017. The financing also supported advancement of Tizona's pipeline based on an immunosuppressive cytokine called IL-35. The company was founded by MPM Capital and is led by Pablo J. Cagnoni as President and Chief Executive Officer.
Jan 2016Series AAmgen Ventures; MPM Capital; Astellas Venture Management; InterWest Partners$27M$112MTizona Therapeutics is a South San Francisco-based biotech company focused on immuno-oncology, developing first-in-class antibodies to modulate the immune system against cancer, including a CCR4-targeting antibody to deplete regulatory T cells and an IL-35 candidate, with plans for additional programs entering clinical trials annually. The company emerged from stealth in 2016 after securing funding across early rounds. Tizona's pipeline at the time emphasized novel mechanisms to counter tumor immunosuppression, positioning it in the competitive immuno-oncology field alongside efforts to release effector T cell brakes. A previously unannounced Series A round raised roughly $27 million from MPM Capital, Amgen Ventures, Astellas Venture Management, and InterWest Partners, matching the specified investors. This was followed closely by a Series B round on March 8, 2016, with a post-money valuation of $111.94 million. Tizona continued raising capital post-2016, including later involvement from Abingworth, Canaan, Lightstone Ventures, and AbbVie Ventures. By July 2020, Gilead Sciences invested $300 million for a 49.9% equity stake, with an option to acquire the remainder for up to $1.25 billion, reflecting strong validation of its pipeline like TTX-080, an anti-HLA-G antibody. Prior to closing, Tizona spun off TTX-030 (in alliance with AbbVie) into a separate entity. Overall funding reached $343 million across four rounds.

Who has invested in Tizona Therapeutics?

8 investors have backed Tizona Therapeutics across its funding rounds, including InterWest Partners, MPM Capital, Amgen Ventures, Astellas Venture Management, Canaan Partners and Lightstone Ventures.

Lead investors include Gilead Sciences and Abingworth.


Tizona Therapeutics Investors

Investors in Tizona Therapeutics by funding rounds participated
InvestorHQRoundsRoleFirst check
Amgen VenturesUnited StatesSan Francisco, CA2ParticipantJan 2016
MPM CapitalUnited StatesBoston, MA2ParticipantJan 2016
Astellas Venture ManagementUnited StatesSan Francisco, CA2ParticipantJan 2016
InterWest PartnersUnited StatesSan Francisco, CA2ParticipantJan 2016
Lightstone VenturesUnited StatesSan Francisco, CA1ParticipantMar 2016
Gilead SciencesUnited StatesSan Francisco, CA1LeadJul 2020

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Tizona Therapeutics Competitors

Tizona Therapeutics competitors include listed companies like Bright Minds Biosciences and Alkaloid, and private ones like Elpiscience Biopharmaceuticals, Iambic, Ottimo Pharma and Terray Therapeutics.

Public and private companies comparable to Tizona Therapeutics
CompanyHQStatusRevenueEBITDAValuation
Elpiscience BiopharmaceuticalsChinaShanghaiPrivate--$600M
IambicUnited StatesSan Diego, CAPrivate--$600M
Ottimo PharmaUnited KingdomSandwichPrivate--$600M
Terray TherapeuticsUnited StatesLos Angeles, CAPrivate--$600M
Bright Minds BiosciencesUnited StatesUnited StatesPublicly listed-($10M)$604M
AlkaloidNorth MacedoniaNorth MacedoniaPublicly listed$391M$62M$605M

Tizona Therapeutics Public Comps

Tizona Therapeutics is still privately-owned, but its public comps include Bright Minds Biosciences, Alkaloid, Allogene Therapeutics, Avalon Pharma, Cormedix, Scribe Therapeutics, Agomab Therapeutics, TTY Biopharm, CytomX Therapeutics and Shattuck Labs.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
Bright Minds Biosciences-($10M)--(39.2x)(10.0x)
Alkaloid$391M$62M1.7x-10.7x-
Allogene Therapeutics-($197M)-122.7x(1.7x)(1.7x)
Avalon Pharma$123M$34M5.1x4.6x18.2x18.3x
Cormedix$312M$164M1.6x1.5x3.0x-
Scribe Therapeutics$51M($21M)14.2x-(34.0x)-
Agomab Therapeutics-($74M)-975.9x(4.2x)(3.8x)
TTY Biopharm$203M$72M2.9x2.8x8.3x-

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Common questions about Tizona Therapeutics

When was Tizona Therapeutics founded?Tizona Therapeutics was founded in 2014.
Where is Tizona Therapeutics headquartered?Tizona Therapeutics is headquartered in San Francisco, CA, United States.
Is Tizona Therapeutics publicly listed?No, Tizona Therapeutics is a private, VC-backed company.
What is Tizona Therapeutics' valuation?Tizona Therapeutics was last valued at $601M in its strategic investment round in July 2020.
How much funding has Tizona Therapeutics raised?Tizona Therapeutics has raised $370M across 3 funding rounds.
What was Tizona Therapeutics' last funding round?Tizona Therapeutics' last funding round was a $300M strategic investment round in July 2020, led by Gilead Sciences.
Who are Tizona Therapeutics' investors?Tizona Therapeutics' investors include Amgen Ventures, MPM Capital, Astellas Venture Management, InterWest Partners, Lightstone Ventures, Gilead Sciences, Canaan Partners and Abingworth.
Which companies are comparable to Tizona Therapeutics?Companies comparable to Tizona Therapeutics include Elpiscience Biopharmaceuticals, Iambic, Ottimo Pharma, Terray Therapeutics, Bright Minds Biosciences and Alkaloid.

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