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- Atsena Therapeutics
Atsena Therapeutics Valuation, Funding & Investors
Atsena Therapeutics is valued at $126M as of December 2020.
Last Atsena Therapeutics valuation
$126M
Series A · Dec 2020
Last Atsena Therapeutics funding round
$150M
Series C · Apr 2025
Cumulative funding Atsena Therapeutics raised
$238M
across 4 funding rounds
Key investors in Atsena Therapeutics
OUP (Osage University Partners)
Hatteras Venture Partners
Sofinnova Investments
Lightstone Ventures
Abingworth
Foundation Fighting Blindness
About Atsena Therapeutics
Atsena Therapeutics is a clinical-stage gene therapy company developing treatments for inherited retinal diseases. The firm advances AAV-based therapies for X-linked retinoschisis and GUCY2D-associated Leber congenital amaurosis using its spreading capsid AAV.SPR platform. Headquartered in Raleigh, North Carolina, Atsena Therapeutics conducts trials targeting genetic mutations causing blindness.
Founded
2019
HQ
Website
Status
Privately held
Customer focus
B2C
Revenue model
Product sales
Valuation
$126M (Dec 2020)
Atsena Therapeutics Valuation
Atsena Therapeutics is currently valued at $126M, based on its Series A in December 2020.
The $55M round was led by Sofinnova Investments, with participation from Lightstone Ventures, University of Florida, Retinal Degeneration Fund, Abingworth, Hatteras Venture Partners and 2 other investors.
Atsena Therapeutics valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Dec 2020 | Series A | $126M |
Atsena Therapeutics Funding History
Atsena Therapeutics has raised a total of $238M across 4 funding rounds.
Atsena Therapeutics' first fundraising round was a $8M Series A in April 2020. The most recent completed round was a $150M Series C in April 2025.
Atsena Therapeutics funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Apr 2025 | Series C | Bain Capital (lead); Lightstone Ventures; Wellington Management; Abingworth; Foundation Fighting Blindness; Sofinnova Investments; Hatteras Venture Partners; OUP (Osage University Partners); Manning Family Foundation | $150M | - | Atsena Therapeutics is a clinical-stage gene therapy company based in Durham, NC, focused on developing genetic medicines to reverse or prevent blindness caused by inherited retinal diseases. The company leverages its proprietary AAV.SPR capsid technology, which enables lateral spreading in ocular tissues, to deliver therapies more effectively. Its lead candidate, ATSN-201, targets X-linked retinoschisis (XLRS), a childhood-onset genetic condition leading to progressive vision loss and eventual blindness, with no approved treatments currently available. ATSN-201 has received FDA Fast Track, Rare Pediatric Disease, and Orphan Drug designations, and positive preliminary data from its ongoing Phase 1/2 LIGHTHOUSE trial are anticipated in late 2025. On April 2, 2025, Atsena announced the closing of an oversubscribed $150 million Series C financing round, led by Bain Capital Life Sciences with new participation from Wellington Management and full support from existing investors including Abingworth, Sofinnova Investments, Lightstone Ventures, Foundation Fighting Blindness, Hatteras Venture Partners, Osage University Partners (OUP), and Manning Family Foundation. The proceeds will fund the advancement of ATSN-201 through potential FDA approval and commercial launch, support preclinical pipeline development for other inherited retinal diseases, and expand the AAV.SPR platform. The round builds on prior funding, including a $24.5 million Series B in October 2023, and aims to carry the company through a biologics license application and beyond, pending FDA discussions on accelerated approval pathways. Atsena's broader pipeline includes ATSN-101 for Leber Congenital Amaurosis type 1 (LCA1), which has shown promising Phase 1/2 results and received FDA Rare Pediatric Disease, Orphan Drug, and Regenerative Medicine Advanced Therapy designations; it is advancing toward a pivotal trial through a collaboration with Nippon Shinyaku announced earlier. Biopharma executive Norbert Riedel, PhD, joined the board as part of the Series C. The funding reflects investor confidence in Atsena's novel science and clinical data amid challenges in the gene therapy sector, positioning it among few ocular gene therapy companies securing nine-figure rounds recently, such as Beacon, Ray, and Frontera. |
| Oct 2023 | Undisclosed stage | - | $25M | - | Atsena Therapeutics is a clinical-stage gene therapy company focused on developing treatments to reverse or prevent blindness, particularly for inherited retinal diseases like X-linked retinoschisis (XLRS). Its lead program, ATSN-201, is an investigational gene therapy in a phase 1/2 Lighthouse trial targeting XLRS, which has no approved treatments and has received FDA fast track, rare pediatric disease, and orphan drug designations. The company employs novel spreading AAV.SPR capsid technology to reach hard-to-treat retinal areas without surgical risks. A much larger oversubscribed $150 million Series C financing closed on April 2, 2025, led by Bain Capital with participation from Wellington Management and existing investors like Sofinnova Investments, Abingworth, Lightstone Ventures, Foundation Fighting Blindness, Hatteras Venture Partners, Osage University Partners, and the Manning Family Foundation. Proceeds will advance ATSN-201 toward potential approval, support the preclinical pipeline including ATSN-101 (partnered with Nippon Shinyaku for a global pivotal study), and expand AAV.SPR applications. As of April 2025, Atsena's total funding reached approximately $237.7 million to $238 million across rounds, with a secondary market valuation of $340 million implying a capital efficiency of 1.43x total capital raised. |
| Dec 2020 | Series A | Sofinnova Investments (lead); Lightstone Ventures; University of Florida; Retinal Degeneration Fund; Abingworth; Hatteras Venture Partners; OUP (Osage University Partners); Manning Family Foundation | $55M | $126M | Atsena Therapeutics is a clinical-stage gene therapy company developing treatments to reverse or prevent blindness from inherited retinal diseases, with a focus on ocular gene therapies using novel AAV vectors. Its lead program targets Leber congenital amaurosis type 1 (LCA1) caused by GUCY2D mutations, affecting about 20% of LCA patients, along with preclinical assets and capsid development. On December 16, 2020, the company closed an oversubscribed $55 million Series A financing led by Sofinnova Investments, with participation from new investors Abingworth and Lightstone Ventures, plus existing backers Hatteras Venture Partners, Foundation Fighting Blindness’ Retinal Degeneration Fund, Osage University Partners, University of Florida, and Manning Family Foundation. The proceeds were allocated to advance the LCA1 gene therapy clinical program, two preclinical assets, and novel capsid development for ocular diseases, while expanding the board with Sarah Bhagat (Sofinnova), Jackie Grant (Abingworth), and Jason Lettmann (Lightstone), and building out the team. Sofinnova highlighted Atsena’s strong foundation in ocular gene therapy as positioning it to become a partner of choice. This round followed seed funding, with a post-money valuation of $125.97 million noted in secondary market data. Atsena continued fundraising post-Series A, raising $24.5 million in a Series B in October 2023 and $150 million in an oversubscribed Series C in April 2025 led by Bain Capital, with returning investors including Sofinnova, Abingworth, and others, to advance lead candidate ATSN-201 for X-linked retinoschisis (XLRS) through phase 1/2 trials and ATSN-101 with partner Nippon Shinyaku. The company faced 2023 layoffs amid gene therapy sector challenges but persists in pivotal studies. |
| Apr 2020 | Series A | Foundation Fighting Blindness (lead); Hatteras Venture Partners (lead); University of Florida; PBM Capital Group; OUP (Osage University Partners) | $8M | - | Atsena Therapeutics, a Durham-based clinical-stage gene therapy company founded in 2019 by Shannon Boye and Sanford Boye, develops treatments to prevent or reverse inherited retinal diseases causing blindness, including Leber congenital amaurosis (LCA1) due to GUCY2D mutations. The company acquired exclusive rights to a gene therapy for LCA1 from Sanofi, originally licensed from the University of Florida, where the therapy was created. In April 2020, Atsena closed a Series 1 funding round of $8.15 million or $8.2 million, led by Foundation Fighting Blindness and Hatteras Venture Partners, with participation from Osage University Partners, PBM Capital, and University of Florida. This funding supported the company's formation and initial development efforts, including proof-of-concept studies backed by the Foundation Fighting Blindness over 15 years. Atsena advanced its pipeline, entering Phase I/II trials for the LCA1 therapy and developing additional programs using adeno-associated virus (AAV) technologies. Subsequent rounds included a $55 million Series A in 2020 and a $24.5 million Series B in October 2023. |
Who has invested in Atsena Therapeutics?
12 investors have backed Atsena Therapeutics across its funding rounds, including OUP (Osage University Partners), Hatteras Venture Partners, Sofinnova Investments, Lightstone Ventures, Abingworth and Foundation Fighting Blindness.
Lead investors include Bain Capital, Sofinnova Investments, Foundation Fighting Blindness and Hatteras Venture Partners.
Atsena Therapeutics Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 3 | Lead | Apr 2020 | ||
| 3 | Participant | Apr 2020 | ||
| 2 | Participant | Dec 2020 | ||
| 2 | Participant | Apr 2020 | ||
| 2 | Participant | Dec 2020 | ||
| 2 | Lead | Apr 2020 | ||
| 2 | Lead | Dec 2020 | ||
| 2 | Participant | Dec 2020 | ||
| 1 | Participant | Apr 2025 | ||
| 1 | Participant | Dec 2020 | ||
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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
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Start Free TrialAtsena Therapeutics Competitors
Atsena Therapeutics competitors include listed companies like Cibus and enGene Therapeutics, and private ones like PlaqueTec, Immunomic Therapeutics, 54gene and Juno Diagnostics.
| Company | HQ | Status | Revenue | EBITDA | Valuation | Revenue Multiple |
|---|---|---|---|---|---|---|
| Private | - | - | $129M | - | ||
| Private | - | - | $150M | - | ||
| Private | - | - | $162M | - | ||
| Publicly listed | $4M | ($91M) | $125M | 28.9x | ||
| Private | - | - | $125M | - | ||
| Publicly listed | - | ($123M) | $128M | - |
Atsena Therapeutics Public Comps
Atsena Therapeutics is still privately-owned, but its public comps include vTv Therapeutics, Orient Europharma Co, Cibus, Inovio Pharmaceuticals, enGene Therapeutics, Nyrada, BRIM Biotechnology, Naturland Holding, Tiziana Life Sciences and Biomea Fusion.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| - | ($33M) | - | 1.5x | (1.2x) | - | |||
| $144M | ($1M) | 1.5x | - | (200.2x) | - | |||
| $4M | ($91M) | 37.8x | 28.9x | (1.5x) | (2.3x) | |||
| $65K | ($84M) | 1475.9x | 194.7x | (1.1x) | - | |||
| - | ($123M) | - | - | - | - | |||
| - | - | - | - | - | - | |||
| $172K | ($14M) | 552.2x | 589.9x | (6.9x) | - | |||
| $19M | $5M | 6.4x | - | 22.7x | - | |||
This data is available for Pro users. Sign up to see all Atsena Therapeutics competitors and their valuation data. Start Free Trial | ||||||||
Common questions about Atsena Therapeutics
| When was Atsena Therapeutics founded? | Atsena Therapeutics was founded in 2019. |
| Where is Atsena Therapeutics headquartered? | Atsena Therapeutics is headquartered in Durham, NC, United States. |
| Is Atsena Therapeutics publicly listed? | No, Atsena Therapeutics is a private, VC-backed company. |
| What is Atsena Therapeutics' valuation? | Atsena Therapeutics was last valued at $126M in its Series A in December 2020. |
| How much funding has Atsena Therapeutics raised? | Atsena Therapeutics has raised $238M across 4 funding rounds. |
| What was Atsena Therapeutics' last funding round? | Atsena Therapeutics' last funding round was a $150M Series C in April 2025, led by Bain Capital. |
| Who are Atsena Therapeutics' investors? | Atsena Therapeutics' investors include Hatteras Venture Partners, OUP (Osage University Partners), Lightstone Ventures, University of Florida, Abingworth, Foundation Fighting Blindness, Sofinnova Investments, Manning Family Foundation, Wellington Management, Retinal Degeneration Fund and 2 others. |
| Which companies are comparable to Atsena Therapeutics? | Companies comparable to Atsena Therapeutics include PlaqueTec, Immunomic Therapeutics, 54gene, Cibus, Juno Diagnostics and enGene Therapeutics. |
See companies similar to Atsena Therapeutics
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