Kardigan Valuation, Funding & Investors

Kardigan is valued at $1.5B as of January 2025.

Last Kardigan valuation

$1.5B

Series A · Jan 2025

Last Kardigan funding round

$254M

Series B · Oct 2025

Cumulative funding Kardigan raised

$554M

across 2 funding rounds

Key investors in Kardigan

  • ARCH Venture Partners
  • Sequoia Heritage
  • Fidelity
  • T. Rowe Price
  • Perceptive Advisors

Kardigan Overview

About Kardigan

Kardigan is a cardiovascular-focused biotechnology company, founded in 2024 by former MyoKardia executives including CEO Tassos Gianakakos, developing therapies for primary and secondary cardiomyopathies and related heart conditions through what it calls a cardiac intelligence platform. Its pipeline includes danicamtiv, a cardiac myosin activator for genetic dilated cardiomyopathy in-licensed from Bristol Myers Squibb; tonlamarsen, an acute severe hypertension candidate from Ionis Pharmaceuticals; and ataciguat, a guanylate cyclase activator for calcific aortic valve stenosis acquired from Sanofi and Mayo Clinic. The company is headquartered in South San Francisco, California and Princeton, New Jersey.


Founded

2023

HQ

United StatesUnited States

Status

Privately held

Customer focus

B2B

Revenue model

Product sales

Valuation

$1.5B (Jan 2025)

Kardigan Valuation

Kardigan is currently valued at $1.5B, based on its Series A in January 2025.

The $300M round was led by ARCH Venture Partners, Perceptive Advisors and Sequoia Heritage.

Kardigan valuation by funding round

Kardigan valuation by funding round
DateStageValuation
Jan 2025Series A$1.5B

Kardigan Funding History

Kardigan has raised a total of $554M across 2 funding rounds.

Kardigan's first fundraising round was a $300M Series A in January 2025. The most recent completed round was a $254M Series B in October 2025.

Kardigan funding rounds

Kardigan funding rounds
DateStageInvestorsRaisedValuationDeal Summary
Oct 2025Series BFidelity; T. Rowe Price; Sequoia Heritage; ARCH Venture Partners$254M-Kardigan, a biotechnology company focused on modernizing cardiovascular drug development through 'cardiac intelligence,' closed a $254 million Series B financing round on October 14, 2025. The round included new investors Fidelity Management & Research Company and accounts advised by T. Rowe Price Investment Management, alongside existing backers ARCH Venture Partners and Sequoia Heritage. Proceeds will advance three late-stage clinical programs: danicamtiv, a cardiac myosin activator for genetic dilated cardiomyopathy (DCM) in-licensed from Bristol Myers Squibb; tonlamarsen, an acute severe hypertension candidate from Ionis Pharmaceuticals; and ataciguat, a guanylate cyclase activator for calcific aortic valve stenosis (CAVS) acquired from Sanofi and Mayo Clinic. Launched in January 2025 with $300 million in initial financing, Kardigan has now raised over $550 million total. The company recently disclosed phase 2a data for danicamtiv showing improvements in left ventricular ejection fraction (LVEF) and left atrial function, presented as late-breaking at the Heart Failure Society of America (HFSA) 2025 conference with a JACC publication. Upcoming milestones include initiation of the KINSHIP-DCM phase 3 trial for danicamtiv in 2025 and multiple readouts starting in 2026, with KATALYST-AV phase 3 sites for ataciguat opening through 2025-2026. Kardigan aims to address unmet needs in cardiovascular diseases—the leading global cause of death—by targeting underlying disease drivers rather than symptoms. CEO Tassos Gianakakos emphasized the capital-efficient model powered by science, data, and technology to deliver first-in-class therapies. The addition of blue-chip public investors signals confidence in the pipeline's potential to transform standards of care in DCM, ASH, and CAVS. Headquartered in South San Francisco, California, and Princeton, New Jersey, Kardigan continues recruiting experts and positioning for pivotal trials and regulatory submissions, with some reports suggesting IPO preparations.
Jan 2025Series AARCH Venture Partners (lead); Perceptive Advisors (lead); Sequoia Heritage (lead)$300M$1.5BKardigan is a biotech company founded in 2024 by former MyoKardia executives, including CEO Tassos Gianakakos, focused on developing innovative therapies for cardiovascular diseases, particularly primary and secondary cardiomyopathies leading to heart failure. The company, headquartered in locations including Cambridge, MA, San Francisco, and Princeton, NJ, has curated a portfolio of late-stage clinical candidates matched to responsive patients using its cardiac intelligence platform, alongside plans for in-licensing and acquisitions. With around 60 employees, Kardigan positions itself to address unmet needs in cardiology where current treatments fall short. Kardigan raised $300 million in an oversize Series A funding round on January 1, 2025 (announced around January 10, 2025), led by Perceptive Advisors, ARCH Venture Partners, and Sequoia Heritage. This post-money valuation reached $1.5 billion, marking a significant milestone for the debutante biotech and reflecting strong investor confidence in its vision and team from the successful MyoKardia acquisition by Bristol Myers Squibb for $13.1 billion in 2020. The financing enables acceleration of clinical trials, including planned Phase 1 and Phase 2 studies for lead candidates targeting heart failure and related conditions. The funds will support scaling operations, advancing drug programs through clinical development, expanding research into novel therapeutic approaches, and building a pipeline via its discovery platform. Investors highlighted Kardigan's unique immune modulation and cardiac approaches as poised to impact autoimmune and cardiovascular spaces. While some reports variably describe focus areas as autoimmune or cardio-specific, consensus centers on cardiovascular therapeutics from MyoKardia veterans. This round positions Kardigan among notable HealthTech and biotech players, leveraging team expertise from Camzyos (mavacamten), which generated $484 million in sales in the first nine months of 2024.

Who has invested in Kardigan?

5 investors have backed Kardigan across its funding rounds, including ARCH Venture Partners, Sequoia Heritage, Fidelity, T. Rowe Price and Perceptive Advisors.

Lead investors include ARCH Venture Partners, Perceptive Advisors and Sequoia Heritage.


Kardigan Investors

Investors in Kardigan by funding rounds participated
InvestorHQRoundsRoleFirst check
Sequoia HeritageUnited StatesSan Francisco, CA2LeadJan 2025
ARCH Venture PartnersUnited StatesChicago, IL2LeadJan 2025
FidelityUnited StatesBoston, MA1ParticipantOct 2025

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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples

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Acquisitions by Kardigan

Kardigan has acquired 1 company to date.

Last acquisition by Kardigan was on March 27th 2025. Kardigan acquired Prolaio for undisclosed valuation.


Latest Acquisitions by Kardigan

Prolaio
Description
Prolaio is a HealthTech company applying prescriptive analytics to orthopedic care. Nashville-based, its platform analyzes patient data from wearables and EHRs to predict risks, optimize surgical planning, and monitor recovery. Prolaio partners with hospitals and surgeons to reduce readmissions and improve joint replacement outcomes.
HQ CountryUnited States
HQ City
Phoenix, AZ
Deal Date27 Mar 2025
Valuationundisclosed
EV/Revenue
EV/EBITDA

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Kardigan Competitors

Kardigan competitors include listed companies like Zhejiang Wolwo Bio-Pharma, Lotus Pharmaceutical, Bicara Therapeutics and Pharma Mar, and private ones like Anew Labs and Verdiva Bio.

Public and private companies comparable to Kardigan
CompanyHQStatusRevenueEBITDAValuationRevenue Multiple
Anew LabsChinaShanghaiPrivate--$1.5B-
Verdiva BioUnited KingdomLondonPrivate--$1.5B-
Zhejiang Wolwo Bio-PharmaChinaChinaPublicly listed$158M$69M$1.5B8.5x
Lotus PharmaceuticalTaiwanTaiwanPublicly listed$644M$252M$1.5B3.2x
Bicara TherapeuticsUnited StatesUnited StatesPublicly listed-($155M)$1.5B-
Pharma MarSpainSpainPublicly listed$255M$77M$1.5B5.5x

Kardigan Public Comps

Kardigan is still privately-owned, but its public comps include Zhejiang Wolwo Bio-Pharma, Lotus Pharmaceutical, Bicara Therapeutics, Pharma Mar, Nippon Shinyaku, Xeris Biopharma, Marksans Pharma, Avalyn Pharma, Innoviva and Natco Pharma.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
Zhejiang Wolwo Bio-Pharma$158M$69M8.3x8.5x19.0x-
Lotus Pharmaceutical$644M$252M4.9x3.2x12.4x8.9x
Bicara Therapeutics-($155M)--(6.4x)(5.4x)
Pharma Mar$255M$77M5.3x5.5x17.5x27.5x
Nippon Shinyaku$1.1B$271M1.0x0.9x3.9x3.9x
Xeris Biopharma$292M$38M5.7x4.6x44.1x28.2x
Marksans Pharma$307M$68M4.7x4.3x21.2x20.2x
Avalyn Pharma-($91M)--(12.5x)(10.1x)

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Common questions about Kardigan

When was Kardigan founded?Kardigan was founded in 2023.
Where is Kardigan headquartered?Kardigan is headquartered in United States.
Is Kardigan publicly listed?No, Kardigan is a private, VC-backed company.
What is Kardigan's valuation?Kardigan was last valued at $1.5B in its Series A in January 2025.
How much funding has Kardigan raised?Kardigan has raised $554M across 2 funding rounds.
What was Kardigan's last funding round?Kardigan's last funding round was a $254M Series B in October 2025.
Who are Kardigan's investors?Kardigan's investors include Sequoia Heritage, ARCH Venture Partners, Fidelity, T. Rowe Price and Perceptive Advisors.
Which companies are comparable to Kardigan?Companies comparable to Kardigan include Anew Labs, Verdiva Bio, Zhejiang Wolwo Bio-Pharma, Lotus Pharmaceutical, Bicara Therapeutics and Pharma Mar.
How many companies has Kardigan acquired?Kardigan has acquired 1 company, including Prolaio.

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