- Companies
- Brise Pharma
Brise Pharma Valuation, Funding & Investors
Brise Pharma is valued at $1.6B as of March 2022.
Last Brise Pharma valuation
$1.6B
Seed · Mar 2022
Last Brise Pharma funding round
$28M
Series A · Nov 2025
Cumulative funding Brise Pharma raised
$229M
across 4 funding rounds
Key investors in Brise Pharma
Qiming Venture Partners
BioTrack Capital
Shunxi Fund
Sherpa Healthcare Partners
INCE Capital
Sinopharm Capital
Brise Pharma Overview
About Brise Pharma
Brise Pharma is a provider of scientific research and technical services in the pharmaceutical sector, focusing on drug development support and laboratory testing.
Founded
2021
HQ
Website
Status
Privately held
Customer focus
B2B
Revenue model
Services
Valuation
$1.6B (Mar 2022)
Sectors
Brise Pharma Valuation
Brise Pharma is currently valued at $1.6B, based on its seed round in March 2022.
The $158M round was led by Boyuan Capital and Qiming Venture Partners, with participation from JIANYI CAPITAL.
Brise Pharma valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Mar 2022 | Seed | $1.6B |
Brise Pharma Funding History
Brise Pharma has raised a total of $229M across 4 funding rounds.
Brise Pharma's first fundraising round was a $23M angel round in October 2021. The most recent completed round was a $28M Series A in November 2025.
Brise Pharma funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Nov 2025 | Series A | Beijing Medical and Health Industry Investment Fund (lead); Prox Ventures; Qiming Venture Partners; Shunxi Fund; Guanghua Wutong Fund; INCE Capital | $28M | - | Brise Pharmaceuticals (also referred to as Brise Pharma) is a clinical-stage biopharmaceutical company focused on developing innovative and highly differentiated analgesic treatments for debilitating pain conditions, including migraine, neuropathic, musculoskeletal, inflammatory, and chronic pain, targeting significant unmet needs with biology-based platforms for the Dorsal Root Ganglion (DRG) and Trigeminovascular System (TVS). Led by CEO Dr. Guochun Li and based in Shanghai, the company has advanced two compounds to the clinical stage in the US and China. Funds from that 2024 raise were allocated to advancing the product pipeline through preclinical and clinical stages, as well as refining and validating the DRG and TVS drug development platforms. |
| Apr 2024 | Seed | Shunxi Fund (lead); Sherpa Healthcare Partners; Qiming Venture Partners; China Gas Yijing; Vinner Therapeutics; BioTrack Capital | $20M | - | Brise Pharmaceuticals is a clinical-stage biopharmaceutical company specializing in innovative treatments for acute and chronic pain, with a focus on migraine, neuropathic pain, and musculoskeletal pain. The company is headquartered in Shanghai, China, and is led by CEO Dr. Guochun Li. It has developed two proprietary drug development platforms: the Trigeminovascular System (TVS) biology-based platform and the Dorsal Root Ganglion (DRG) biology-based platform. In April 2024, Brise completed Pre-A and Pre-A+ financing rounds totaling approximately $20 million. The Pre-A round was led by Shunxi Fund and included participation from Cnfuel Capital, Vinner Therapeutics, and existing investors Qiming Venture Partners and BioTrack Capital. The Pre-A+ round was exclusively invested by Sherpa Healthcare Partners. The capital raised is intended to advance the company's preclinical and clinical product pipeline and further refine the TVS and DRG biology-based drug development platforms. Brise has advanced two molecules to the clinical stage in the United States and China. The company's pipeline includes BR-01T for chronic low back pain (currently in Phase I), BR-005 for acute and preventive migraine treatment, BR-007 for Camurati-Engelmann disease, BR-008 for chronic neuropathic pain, and BR-009 for preventive migraine treatment. As a clinical-stage biotech firm, Brise had no reported revenue at the time of the funding round. |
| Mar 2022 | Seed | Boyuan Capital (lead); Qiming Venture Partners (lead); JIANYI CAPITAL | $158M | $1.6B | Brise Pharma, based in Shanghai, China, and founded in 2021, is an innovative biomedical research and development company specializing in biotechnology, particularly in biopharmaceuticals, oncology/cancer treatment, specialty pharmaceuticals, and pharmaceutical R&D, with a focus on pain therapeutics, oncology, and chronic diseases. The company develops innovative biomedical products based on human genetic and pathological mechanisms to select optimal drug treatments and delivery routes, building its pain therapeutic pipeline through in-house research, co-development, mergers, and clinical trial strategies to enhance drug accessibility and commercial value. It generates revenue by providing innovative drugs in the field of pain treatment. Brise Pharma operates in the HealthTech and manufacturing sectors, with a website at www.brisepharma.com, and focuses on expanding clinical trials and drug pipelines. A later November 2025 Series A round was led by Shunxi Fund with participation from INCE Capital, Geuniom Group, Proxima Ventures, and returning investor Qiming Venture Partners, aimed at advancing the preclinical and clinical development of the BR005 program, a small molecule CGRP-class drug for pain treatment. |
| Oct 2021 | Angel | BioTrack Capital (lead); Sinopharm Capital; Qiming Venture Partners | $23M | - | Brise Pharma, founded in 2021 and based in Shanghai, China, is an innovative biomedical research and development company focusing on biotechnology, particularly in oncology, chronic diseases, and pain therapeutics. It develops innovative biomedical products based on human genetic and pathological mechanisms to select optimal drug treatments and delivery routes, building a pain therapeutic pipeline through in-house research, co-development, and mergers. The company generates revenue by providing innovative drugs in pain treatment and uses funding to advance preclinical and clinical-stage programs, such as the BR005 small molecule drug in the CGRP class. Later developments include a Series A funding in November 2025 led by returning investor Shunxi Fund, with participation from new investors INCE Capital, Geuniom Group, Proxima Ventures, and returning Qiming Venture Partners, to accelerate clinical trials for pain treatment pipelines. BioTrack Capital, a China-based VC firm focused on health care, biotechnology, and medical investments (Series A/B/C stages in China, US, Japan), is noted as a portfolio investor in Brise Pharma alongside others like Qiming Venture Partners. |
Who has invested in Brise Pharma?
13 investors have backed Brise Pharma across its funding rounds, including Qiming Venture Partners, BioTrack Capital, Shunxi Fund, Sherpa Healthcare Partners, INCE Capital and Sinopharm Capital.
Lead investors include Beijing Medical and Health Industry Investment Fund, Shunxi Fund, Boyuan Capital, Qiming Venture Partners and BioTrack Capital.
Brise Pharma Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 4 | Lead | Oct 2021 | ||
| 2 | Lead | Apr 2024 | ||
| 2 | Lead | Oct 2021 | ||
| 1 | Participant | Oct 2021 | ||
| 1 | Participant | Mar 2022 | ||
| 1 | Participant | Nov 2025 | ||
| 1 | Participant | Apr 2024 | ||
| 1 | Participant | Apr 2024 | ||
| -- | 1 | Participant | Apr 2024 | |
| 1 | Lead | Mar 2022 | ||
| 1 | Lead | Nov 2025 | ||
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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
Sign up to see data on 350K+ funding rounds and disclosed revenue and EBITDA valuation multiples, from seed, through growth stage, to pre-IPO.
Start Free TrialBrise Pharma Competitors
Brise Pharma competitors include listed companies like Syndax, Idorsia, Kardigan and Eton Pharmaceuticals, and private ones like Pathos and Anew Labs.
| Company | HQ | Status | Revenue | EBITDA | Valuation | Revenue Multiple |
|---|---|---|---|---|---|---|
| Publicly listed | $172M | ($274M) | $1.6B | 5.8x | ||
| Publicly listed | $268M | ($55M) | $1.6B | 11.5x | ||
| Publicly listed | - | ($197M) | $1.6B | - | ||
| Publicly listed | $80M | $3M | $1.6B | 12.3x | ||
| Private | $13M | $3M | $1.6B | 123.1x | ||
| Private | - | - | $1.5B | - |
Brise Pharma Public Comps
Brise Pharma is still privately-owned, but its public comps include Syndax, Idorsia, Kardigan, Eton Pharmaceuticals, Square Pharma, Yantai Dongcheng, Innoviva, Inhibrx Biosciences, Natco Pharma and Zhejiang Wolwo Bio-Pharma.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| $172M | ($274M) | 9.3x | 5.8x | (5.9x) | (8.6x) | |||
| $268M | ($55M) | 11.5x | 11.5x | (55.7x) | (50.7x) | |||
| - | ($197M) | - | - | (4.9x) | - | |||
| $80M | $3M | 19.9x | 12.3x | 496.2x | 39.4x | |||
| $620M | $183M | 1.7x | 1.5x | 5.8x | 5.0x | |||
| $409M | $81M | 4.2x | 4.3x | 21.5x | 18.8x | |||
| $411M | $349M | 3.0x | 2.8x | 3.5x | 5.2x | |||
| $1M | ($133M) | 1277.8x | 4528.3x | (12.5x) | - | |||
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Common questions about Brise Pharma
| When was Brise Pharma founded? | Brise Pharma was founded in 2021. |
| Where is Brise Pharma headquartered? | Brise Pharma is headquartered in Shanghai, China. |
| Is Brise Pharma publicly listed? | No, Brise Pharma is a private, VC-backed company. |
| What is Brise Pharma's valuation? | Brise Pharma was last valued at $1.6B in its seed round in March 2022. |
| How much funding has Brise Pharma raised? | Brise Pharma has raised $229M across 4 funding rounds. |
| What was Brise Pharma's last funding round? | Brise Pharma's last funding round was a $28M Series A in November 2025, led by Beijing Medical and Health Industry Investment Fund. |
| Who are Brise Pharma's investors? | Brise Pharma's investors include Qiming Venture Partners, Shunxi Fund, BioTrack Capital, Sinopharm Capital, JIANYI CAPITAL, Prox Ventures, Sherpa Healthcare Partners, China Gas Yijing, Vinner Therapeutics, Boyuan Capital and 3 others. |
| Which companies are comparable to Brise Pharma? | Companies comparable to Brise Pharma include Syndax, Idorsia, Kardigan, Eton Pharmaceuticals, Pathos and Anew Labs. |
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