TISSIUM Valuation, Funding & Investors

Convergent Therapeutics is a clinical-stage biotechnology company based in Cambridge, Massachusetts, that develops radiopharmaceuticals for cancer treatment. Its lead program, CONV01-alpha, is a radioantibody that binds to prostate-specific membrane antigen to deliver a radioactive payload selectively to prostate cancer cells while sparing healthy tissue. The company is building a broader pipeline of similar radioantibody therapies targeting prostate cancer and other solid tumors.

Restor3d is a Durham, North Carolina-headquartered medical device company specializing in 3D-printed orthopedic implants. The firm produces patient-specific titanium craniomaxillofacial plates, spinal spacers, and pelvic reconstruction devices using AI-optimized designs for osseointegration. FDA-cleared products serve surgeons at hospitals like Mayo Clinic, integrating digital planning software for precise anatomical fits in trauma and oncology cases.

Unlearn.AI is a clinical trial platform generating digital twins of patients using machine learning models trained on historical data. Its TwinRCT design accelerates biopharma studies by reducing required participants while maintaining statistical power for endpoints. Headquartered in San Francisco, the company partners with Pfizer and Roche on trials for Alzheimer's and oncology indications.

EndoQuest Robotics is a US-based medical device company developing the ColubrisMX robotic system for minimally invasive fetal and neurosurgery. The platform enables access to uterine and intracranial spaces for treating spina bifida, tumors, and vascular malformations. Headquartered in Newark, California, EndoQuest collaborates with fetal medicine centers for clinical trials, aiming for procedures via 3mm incisions.

Alleviant Medical develops the Alleviant Heart Stabilizer, a transcatheter mitral valve repair device for congestive heart failure patients. Inserted via femoral artery access, the implant reshapes the mitral annulus to reduce regurgitation and improve cardiac output. Targeting the 6 million US heart failure cases, the system aims to cut hospital readmissions by 50 percent in clinical trials. Based in Tampa, Florida, the company raised Series A funding in 2021 and plans FDA pivotal studies.

Anika Therapeutics Inc is an orthopedic medicines company. It is committed to improving the lives of patients with degenerative orthopedic diseases and traumatic conditions with clinically meaningful therapies. The company focuses on orthopedics, including osteoarthritis pain management, regenerative solutions, soft tissue repair, and bone preserving joint technologies. Geographically, it derives a majority of its revenue from the United States and also has its presence in Europe and Other countries.

Dong-A ST Co Ltd is a Korea-based company principally engaged in the manufacturing and distribution of specialty pharmaceuticals. The company also involves in the provision of medical devices, diagnostic detection, as well as overseas sale business. Its in-house developed original drugs are used for gastritis treatment, erectile dysfunction treatment, functional dyspepsia, oxazolidinone class antibiotic, and diabetes treatment.

Aerin Medical is a Sunnyvale, California-headquartered health technology company developing radiofrequency devices for nasal airway treatments. Its VivAer system treats nasal obstruction, while RhinAer addresses chronic rhinitis by remodeling soft tissues in outpatient procedures. FDA-cleared in 2019 and 2020, the products equip ENT physicians in over 500 U.S. clinics as surgery alternatives.

Profound Medical Corp is a commercial-stage medical device company focused on the development and marketing of customizable, incision-free therapeutic systems for the image-guided ablation of diseased tissue utilizing its platform technologies and leveraging the healthcare system's existing imaging infrastructure. The company's product TULSA-PRO system combines real-time MRI, robotically driven transurethral sweeping-action thermal ultrasound with closed-loop temperature feedback control for the ablation of prostate tissue. The product is comprised of one-time-use devices and durable equipment that are used in conjunction with a customer's existing MRI scanner.

Medipost Co Ltd is a Korea-based stem cell biotechnology company. The company is engaged in developing products to meet unmet medical needs. The company operates its business through four distinct segments: Stem Cell Therapeutics, Cord Blood Bank, Cosmetics, and Health Supplements. The Cord Blood Bank Division is involved in collecting and storing stem cells from the newborn's umbilical cord. The Stem Cell Therapeutics division manufactures allogeneic stem cell drug products. The Health Supplements division offers vitamins and nutritional supplements. The Cosmetics division is involved in the sales and marketing of natural cosmetics.