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- Syndesi Therapeutics
Syndesi Therapeutics Acquisition, Valuation, Funding & Investors
Syndesi Therapeutics was acquired by AbbVie for $1B in March 2022.
Cumulative funding Syndesi Therapeutics raised
$28M
across 2 funding rounds
Key investors in Syndesi Therapeutics
Novo Holdings
Johnson & Johnson Innovation
S.R.I.W.
Fountain Healthcare Partners
V-Bio Ventures
VIVES Funds
UCB Ventures
About Syndesi Therapeutics
Syndesi Therapeutics is a Lausanne-based biotech developing small molecules targeting SV2A to modulate synaptic transmission for Alzheimer's and cognitive disorders. The platform, exclusively licensed from UCB in 2021, advances lead compounds into Phase 1 trials demonstrating safety and biomarker modulation. Syndesi focuses on protein-protein interactions regulating neurotransmitter release. Founded in 2020, it collaborates with CROs in Switzerland for preclinical efficacy in amyloid and tau models.
Founded
2018
HQ
Website
Status
Acquired
Customer focus
B2B
Revenue model
Product sales
Valuation
$1B (acquired Mar 2022)
Sectors
Syndesi Therapeutics Acquisition
Syndesi Therapeutics was acquired by AbbVie for $1B on 1 March 2022.
Before the acquisition Syndesi Therapeutics had raised $28M across 2 funding rounds.
| Acquirer | Date | Type | Price |
|---|---|---|---|
| 1 Mar 2022 | Strategic M&A | $1B |
Syndesi Therapeutics Funding History
Syndesi Therapeutics has raised a total of $28M across 2 funding rounds.
Syndesi Therapeutics' first fundraising round was a $21M Series A in February 2018. The most recent completed round was a $7M Series A in September 2020.
Syndesi Therapeutics funding rounds
| Date | Stage | Investors | Raised | Deal Summary |
|---|---|---|---|---|
| Sep 2020 | Series A | Novo Holdings (lead); S.R.I.W.; UCB Ventures; VIVES Funds; Fountain Healthcare Partners; V-Bio Ventures; Johnson & Johnson Innovation | $7M | Syndesi Therapeutics is a Belgium-based biotech company developing novel modulators of the synaptic vesicle protein 2A (SV2A), including lead candidate SDI-118, for treating cognitive impairment in neurodegenerative and neuropsychiatric diseases such as Alzheimer's and major depressive disorder. The company was co-created in 2018 by Novo Holdings' Novo Seeds and UCB Pharma, licensing SDI-118 from UCB to advance into clinical Phase 1b studies. Syndesi's Series A financing was co-led by Novo Holdings and Fountain Healthcare Partners, with participation from Johnson & Johnson Innovation – JJDC, Inc., SRIW, UCB Ventures, V-Bio Ventures, and Vives Louvain Technology Fund. In March 2022, AbbVie acquired Syndesi for up to $1 billion, including $130 million upfront and up to $870 million in milestones, to bolster its neuroscience portfolio with SDI-118, which had shown safety and tolerability in Phase 1 studies and was entering proof-of-principle trials. |
| Feb 2018 | Series A | Novo Holdings (lead); S.R.I.W.; VIVES Funds; Fountain Healthcare Partners; V-Bio Ventures; Johnson & Johnson Innovation | $21M | Syndesi Therapeutics is a Belgium-based biotech company focused on developing novel modulators of the synaptic vesicle protein 2A (SV2A) for treating cognitive impairment associated with neurodegenerative and neuropsychiatric disorders, including Alzheimer’s disease and major depressive disorder. The company exclusively licensed its lead candidate SDI-118, a first-in-class small molecule, from UCB Biopharma and progressed it into Phase 1b proof-of-principle studies. Syndesi was co-created in 2018 through a collaboration between Novo Seeds (part of Novo Holdings) and UCB Pharma as a spinout for assets no longer aligned with UCB's strategy. In February 2018, Syndesi raised a Series A round totaling €17 million (approximately $20.7 million), co-led by Novo Seeds and Fountain Healthcare Partners, with participation from Johnson & Johnson Innovation, S.R.I.W., V-Bio Ventures, and Vives Louvain Technology Fund. This funding enabled the company to advance SDI-118 from early development into clinical studies, including two small Phase I trials that demonstrated safety, tolerability, and promising EEG data on brain activity, followed by Phase Ib dosing about eight months later. In March 2022, AbbVie acquired Syndesi for up to $1 billion, including a $130 million upfront payment and up to $870 million in milestone payments, to bolster its neuroscience portfolio with SDI-118. Investors, including Fountain Healthcare Partners and Novo Holdings, benefited from the exit, positioning the program for late-stage development under AbbVie. |
Who has invested in Syndesi Therapeutics?
7 investors have backed Syndesi Therapeutics across its funding rounds, including Novo Holdings, Johnson & Johnson Innovation, S.R.I.W., Fountain Healthcare Partners, V-Bio Ventures and VIVES Funds.
Lead investors include Novo Holdings.
Syndesi Therapeutics Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 2 | Lead | Feb 2018 | ||
| 2 | Participant | Feb 2018 | ||
| 2 | Participant | Feb 2018 | ||
| 2 | Participant | Feb 2018 | ||
| 2 | Participant | Feb 2018 | ||
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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
Sign up to see data on 350K+ funding rounds and disclosed revenue and EBITDA valuation multiples, from seed, through growth stage, to pre-IPO.
Start Free TrialSyndesi Therapeutics Competitors
Syndesi Therapeutics competitors include listed companies like TchaikaPharma and Chengdu Kanghua, and private ones like BenevolentAI, Biossil, Immunai and Orca Bio.
| Company | HQ | Status | Revenue | EBITDA | Valuation | Revenue Multiple |
|---|---|---|---|---|---|---|
| Private | $10M | - | $1B | 100.0x | ||
| Private | - | - | $1B | - | ||
| Private | - | - | $1B | - | ||
| Private | - | - | $1B | - | ||
| Publicly listed | $37M | $5M | $1000M | - | ||
| Publicly listed | $175M | $50M | $996M | 4.6x |
Syndesi Therapeutics Public Comps
Syndesi Therapeutics is no longer listed, but its public comps include TchaikaPharma, Chengdu Kanghua, Changchun BCHT, Savara, Harrow, Alto Neuroscience, MoonLake, Strides Pharma, Oscotec and TOWA Pharmaceutical.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| $37M | $5M | 27.5x | - | 187.4x | - | |||
| $175M | $50M | 4.9x | 4.6x | 17.1x | 16.9x | |||
| $91M | ($30M) | 11.5x | 11.8x | (34.9x) | (39.5x) | |||
| - | ($123M) | - | 430.7x | (6.9x) | - | |||
| $272M | $42M | 4.5x | 3.6x | 28.8x | 16.6x | |||
| - | ($67M) | - | - | (11.5x) | (6.9x) | |||
| - | ($220M) | - | - | (2.7x) | (2.3x) | |||
| $492M | $106M | 2.3x | 2.1x | 10.9x | 10.7x | |||
This data is available for Pro users. Sign up to see all Syndesi Therapeutics competitors and their valuation data. Start Free Trial | ||||||||
Common questions about Syndesi Therapeutics
| When was Syndesi Therapeutics founded? | Syndesi Therapeutics was founded in 2018. |
| Where is Syndesi Therapeutics headquartered? | Syndesi Therapeutics is headquartered in Brussels, Belgium. |
| Is Syndesi Therapeutics publicly listed? | No, Syndesi Therapeutics was acquired by AbbVie in March 2022. |
| Who acquired Syndesi Therapeutics? | Syndesi Therapeutics was acquired by AbbVie in March 2022. |
| How much was Syndesi Therapeutics acquired for? | Syndesi Therapeutics was acquired for $1B in March 2022. |
| How much funding has Syndesi Therapeutics raised? | Syndesi Therapeutics has raised $28M across 2 funding rounds. |
| What was Syndesi Therapeutics' last funding round? | Syndesi Therapeutics' last funding round was a $7M Series A in September 2020, led by Novo Holdings. |
| Who are Syndesi Therapeutics' investors? | Syndesi Therapeutics' investors include Novo Holdings, S.R.I.W., VIVES Funds, Fountain Healthcare Partners, V-Bio Ventures, Johnson & Johnson Innovation and UCB Ventures. |
| Which companies are comparable to Syndesi Therapeutics? | Companies comparable to Syndesi Therapeutics include BenevolentAI, Biossil, Immunai, Orca Bio, TchaikaPharma and Chengdu Kanghua. |
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