Reprieve Cardiovascular Valuation, Funding & Investors

Cloudnine Hospitals is an India-based chain of specialty hospitals focused on maternity, gynecology, neonatology, and pediatrics care. Operating 20 facilities in Bengaluru, Chennai, Gurgaon, Mumbai, Pune, and Chandigarh since 2007, it delivers over 50,000 births annually with level 3 NICUs and fertility centers. The network adheres to NABH accreditation standards, providing services like high-risk pregnancy management and pediatric surgeries. Cloudnine expands to additional cities including Delhi and Hyderabad, serving urban middle-class families.

Myriad Genetics Inc is a molecular diagnostics and precision medicine company committed to advancing health and well-being for all. The company develops and commercializes molecular tests that help patients and providers uncover genetic insights. Its tests assess the risk of developing disease or disease progression and guide treatment decisions across medical specialties, supporting earlier detection, more precise treatment, and lowering healthcare costs. Its tests include BRACAnalysis CDx, EndoPredict, FirstGene, Foresight, GeneSight, MyChoice CDx, MyRisk (cancer treatment), MyRisk (cancer risk), Prequel, Precise Tumor, Prolaris, and SneakPeek. The company operates in the US and Rest of World, with maximum revenue from the US.

InSightec is a Haifa-based pioneer in magnetic resonance-guided focused ultrasound for non-invasive surgeries. The Exablate Neuro system treats essential tremor and Parkinsonian tremor, earning FDA approval in 2016 after initial uterine fibroid clearance in 2004. InSightec's technology also addresses bone metastases pain and adenomyosis, with installations in over 100 centers globally including Mayo Clinic and University of Toronto.

Orchestra BioMed Holdings Inc is a biomedical innovation company accelerating high-impact technologies to patients through risk-reward sharing partnerships. Its partnership-enabled business model focuses on forging strategic collaborations with medical device companies to drive the commercialization of the products it develops. The company's flagship product candidates include BackBeat Cardiac Neuromodulation Therapy (CNT) for the treatment of hypertension and Virtue Sirolimus AngioInfusionBalloon (SAB) for the treatment of atherosclerotic artery disease.

Shoulder Innovations Inc is a commercial-stage medical technology company exclusively focused on transforming the shoulder surgical care market. It currently offers advanced implant systems for shoulder arthroplasty. Its products include: InSet Total Shoulder Arthroplasty; InSet Reverse Shoulder Arthroplasty; ProVoyance Shoulder Planning Software; and InSet Tray System.

Calyxo is a medical device company based in Pleasanton, California, focused on treatments for kidney stones. Its CVAC Aspiration System uses irrigation and aspiration technology to remove kidney stones, aiming for surgically stone-free outcomes that have historically been difficult to achieve consistently. The system has been used to treat more than 1,300 patients in the United States as the company commercializes its technology.

Genalyte is a San Diego-headquartered life sciences company commercializing the Maverick platform for multiplexed protein and nucleic acid detection using silicon photonics. The technology enables rapid, chip-based immunoassays measuring dozens of biomarkers from a single blood sample in minutes. Genalyte targets autoimmune, infectious disease, and cardiology diagnostics, with FDA-cleared tests for rheumatoid arthritis and lupus markers.

Eko Health is an Emeryville-headquartered digital health firm developing FDA-cleared stethoscopes, telehealth software, and AI algorithms for cardiac and pulmonary disease detection. Its devices, like the CORE 500 and DUO ECG, integrate with electronic health records and are deployed in clinics, hospitals, and telemedicine across the United States and Europe, backed by partnerships with Mayo Clinic and Sutter Health.

TOPI Imaging Technology is a Taiwan-based medical device manufacturer producing optical coherence tomography systems for retinal diagnostics and swept-source optical biometers for intraocular lens calculations. The company's OCT devices image macular degeneration and glaucoma while biometers measure axial length pre-surgery. TOPI supplies systems to ophthalmology clinics in Asia and exports to Europe under ISO 13485 certification.

Beacon Therapeutics is a London-headquartered gene therapy company targeting inherited retinal diseases causing blindness. The firm advances GT005, an AAV-delivered therapy for wet AMD choroidal neovascularization, with Phase 2b trials ongoing in the United States and Europe following seed funding from Oxford Nanopore founders.

LightForce Orthodontics makes a fully personalized, 3D-printed braces system that uses AI and digital workflows to design custom brackets for each patient's anatomy. Orthodontists use the platform for treatment planning, from intraoral scans through final prescriptions, aiming to shorten treatment timelines and reduce the number of patient visits compared with standard orthodontics. The company manufactures its brackets in the United States, including at a facility in Wilmington, Massachusetts.

Perspective Therapeutics Inc is a radiopharmaceutical development company that is pioneering advanced treatment applications for cancers throughout the body. The Company has a proprietary technology that utilizes the alpha-emitting isotope Lead-212 (212Pb) to deliver powerful radiation specifically to cancer cells via specialized targeting moieties.