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- Hexagon Bio
Hexagon Bio Valuation, Funding & Investors
Hexagon Bio is valued at $297M as of October 2022.
Last Hexagon Bio valuation
$297M
Series B · Oct 2022
Last Hexagon Bio funding round
$62M
Series C · Oct 2026
Cumulative funding Hexagon Bio raised
$256M
across 5 funding rounds
Key investors in Hexagon Bio
8VC
The Column Group
Two Sigma Ventures
Nextech Invest
CPP Investments
SoftBank Group
About Hexagon Bio
Hexagon Bio is a Menlo Park-based biotechnology company engineering small molecule therapeutics from fungal genomes. Its platform merges data science and synthetic biology to identify drug candidates targeting unmet needs in infectious diseases and oncology through natural product optimization.
Founded
2016
HQ
Website
Status
Privately held
Customer focus
B2B
Revenue model
Licensing
Valuation
$297M (Oct 2022)
Hexagon Bio Valuation
Hexagon Bio is currently valued at $297M, based on its Series B in October 2022.
The $77M round included Nextech Invest, The Column Group, 8VC, ATEL Growth Capital, CPP Investments and 1 other investor.
Hexagon Bio valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Oct 2022 | Series B | $297M |
Hexagon Bio Funding History
Hexagon Bio has raised a total of $256M across 5 funding rounds.
Hexagon Bio's first fundraising round was a $8M seed round in June 2017. The most recent completed round was a $62M Series C in October 2026.
Hexagon Bio funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Oct 2026 | Series C | The Column Group (lead); Nextech Invest; Deviation Capital; 8VC; CPP Investments | $62M | - | Hexagon Bio, a Menlo Park biopharmaceutical company, announced the closing of a USD 62 million Series C financing on 23 October 2026. The round was led by The Column Group, with participation from existing investors Nextech Invest, Deviation Capital, 8VC and CPP Investments. The company said the proceeds will advance HEX-360, a HER2-targeting antibody-drug conjugate with a novel translation inhibitor payload, into the clinic and expand its pipeline of antibody-drug conjugates with novel payload mechanisms. A first-in-human study of HEX-360 is anticipated to begin in the first half of 2027. Hexagon Bio develops antibody-drug conjugate payloads with mechanisms beyond topoisomerase and tubulin inhibitors, aiming to bypass resistance pathways in solid tumours. The company was founded in 2016 and is led by co-founder and chief executive Maureen Hillenmeyer. It previously raised USD 61 million in September 2021 for small-molecule medicines mined from microbial genomes. |
| Oct 2022 | Series B | Nextech Invest; The Column Group; 8VC; ATEL Growth Capital; CPP Investments; Two Sigma Ventures | $77M | $297M | Hexagon Bio is a Menlo Park, California-based biopharmaceutical company that pioneers the discovery of small molecule therapeutics encoded in the global metagenome of microbes such as bacteria and fungi. Its interdisciplinary platform integrates machine learning, genomics, chemistry, and synthetic biology to build a proprietary database of microbial genomes 10x larger than public databases, enabling systematic identification and optimization of novel compounds targeting proteins implicated in diseases. The company focuses initially on oncology and infectious diseases, mining uncultured microbial genomes to uncover metabolites evolved to inhibit disease-relevant proteins. In February 2023, Hexagon Bio announced a $77.3 million Series B financing round with participation from existing investors including The Column Group, Two Sigma Ventures, 8VC, and Nextech Invest, joined by new investor Canada Pension Plan Investment Board (CPP Investments). This followed a $61 million raise in 2021 led by Nextech Invest and a $47 million Series A in 2020 led by The Column Group, bringing total venture financing to over $185 million since 2017. Proceeds are intended to expand the platform's capabilities, grow the team across disciplines, and advance initial programs toward development candidate nomination. The Series B announcement coincided with leadership strengthening: Tara Arvedson, former Executive Director of Oncology Research at Amgen, was promoted to Chief Scientific Officer after joining as SVP Research, and Victor Cee, former Amgen project leader for Lumakras (sotorasib), joined as SVP Drug Discovery. |
| Sep 2021 | Undisclosed stage | Nextech Invest (lead); The Column Group; SoftBank Group; 8VC; Casdin Capital; Two Sigma Ventures | $61M | - | Hexagon Bio is a biopharmaceutical company based in Menlo Park, CA, pioneering the discovery of novel small-molecule medicines by mining microbial genomes from the global metagenome. Its interdisciplinary platform integrates machine learning, genomics, synthetic biology, and automation to identify drug-like compounds evolved over millions of years, targeting diseases with unmet needs, initially in oncology and infectious diseases. The company raised $61 million in a funding round announced on September 22, 2021, led by Nextech Invest, with participation from new investors SoftBank Vision Fund 2 and Casdin Capital, plus existing investors The Column Group, 8VC, and Two Sigma Ventures. This brought total committed funding to over $108 million, following a prior $47 million Series A. Proceeds were allocated to expand the drug discovery platform and advance a preclinical pipeline. Nextech Invest's managing partner Jakob Loven, Ph.D., joined the board. |
| Sep 2020 | Series A | The Column Group (lead); 8VC; LeFrak; Two Sigma Ventures | $47M | - | Hexagon Bio is a data-driven biotechnology company headquartered in Menlo Park, CA, that develops targeted small molecule therapeutics by combining data science, genomics, synthetic biology, and automation to mine fungal genomes for potent, evolutionarily refined molecules addressing unmet needs in oncology, infectious diseases, and potentially immunology, cardiovascular, neurological, and metabolic disorders. The company launched in 2017 and focuses on discovering secondary metabolites and their protein targets to combat drug-resistant infections and cancer. On approximately September 15, 2020, Hexagon Bio closed a $47 million Series A financing round led by The Column Group, with participation from 8VC and Two Sigma Ventures, bringing total funding to $55 million at that point. The round valued the company at $33.2 million and supported expansion of its interdisciplinary platform, addition of drug discovery capabilities, and hiring Tod Smeal, PhD, formerly of Eli Lilly, Pfizer, and SUGEN, as Chief Scientific Officer. The company has continued raising capital, including additional Series A extensions and a $61 million round in September 2021 led by Nextech Invest with SoftBank Vision Fund 2, Casdin Capital, and existing investors, totaling over $108 million, followed by a $77.3 million Series B in February 2023, pushing cumulative funding to $205.6 million across multiple rounds with the same core investors. |
| Jun 2017 | Seed | 8VC (lead); bpd partners | $8M | - | Hexagon Bio, a biopharmaceutical company, uses data science, genomics, synthetic biology, and automation to discover potent small molecules from fungal genomes for therapeutics targeting oncology and infectious diseases. The company launched in 2017. In June or July 2017, Hexagon Bio raised $8.3 million in a seed round led by 8VC with participation from bpd partners or others, followed by additional early financings including an $8.4 million Series Seed in November 2017. Subsequent rounds included a $47 million Series A in 2020 led by The Column Group with 8VC and Two Sigma Ventures, bringing total funding to $55 million at that time, a $61 million round in September 2021 led by Nextech Invest with SoftBank Vision Fund 2, Casdin Capital, The Column Group, 8VC, and Two Sigma Ventures, and a $77.3 million Series B in February 2023 with The Column Group, Two Sigma Ventures, 8VC, Nextech, and CPP Investments, for total funding over $205 million across six rounds. |
Who has invested in Hexagon Bio?
11 investors have backed Hexagon Bio across its funding rounds, including 8VC, The Column Group, Two Sigma Ventures, Nextech Invest, CPP Investments and SoftBank Group.
Lead investors include The Column Group, Nextech Invest and 8VC.
Hexagon Bio Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 5 | Lead | Jun 2017 | ||
| 4 | Lead | Sep 2020 | ||
| 3 | Lead | Sep 2021 | ||
| 3 | Participant | Sep 2020 | ||
| 2 | Participant | Oct 2022 | ||
| 1 | Participant | Jun 2017 | ||
| 1 | Participant | Oct 2026 | ||
| 1 | Participant | Sep 2021 | ||
| 1 | Participant | Sep 2021 | ||
This data is available for Pro users. Sign up to see all 11 Hexagon Bio investors. Start Free Trial | ||||
Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
Sign up to see data on 350K+ funding rounds and disclosed revenue and EBITDA valuation multiples, from seed, through growth stage, to pre-IPO.
Start Free TrialHexagon Bio Competitors
Hexagon Bio competitors include listed companies like Scribe Therapeutics and Abclon, and private ones like Geneplus-Beijing Co. Ltd., Valo Health, CureGenetics and Next Generation Gene Therapeutics.
| Company | HQ | Status | Revenue | EBITDA | Valuation |
|---|---|---|---|---|---|
| Private | - | - | $295M | ||
| Private | - | - | $300M | ||
| Private | - | - | $311M | ||
| Private | - | - | $267M | ||
| Publicly listed | $51M | ($21M) | $294M | ||
| Publicly listed | $4M | ($13M) | $273M |
Hexagon Bio Public Comps
Hexagon Bio is still privately-owned, but its public comps include Benitec Biopharma, Ildong Pharmaceutical, Agenus, Gen İlaç, SAB Bio, Scribe Therapeutics, Northwest Biotherapeutics, Julphar, Valerio Therapeutics and ARS Pharmaceuticals.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| - | ($51M) | - | - | (2.5x) | - | |||
| $424M | $49M | 0.8x | 0.8x | 7.0x | - | |||
| $114M | $62M | 2.8x | 2.6x | 5.2x | - | |||
| $384M | $48M | 1.1x | - | 8.7x | - | |||
| - | $15M | - | - | 13.7x | (2.5x) | |||
| $51M | ($21M) | 8.1x | - | (19.2x) | - | |||
| $1M | ($50M) | 258.5x | - | (7.2x) | (6.4x) | |||
| $293M | $34M | 0.9x | 0.9x | 8.0x | 5.9x | |||
This data is available for Pro users. Sign up to see all Hexagon Bio competitors and their valuation data. Start Free Trial | ||||||||
Common questions about Hexagon Bio
| When was Hexagon Bio founded? | Hexagon Bio was founded in 2016. |
| Where is Hexagon Bio headquartered? | Hexagon Bio is headquartered in San Francisco, CA, United States. |
| Is Hexagon Bio publicly listed? | No, Hexagon Bio is a private, VC-backed company. |
| What is Hexagon Bio's valuation? | Hexagon Bio was last valued at $297M in its Series B in October 2022. |
| How much funding has Hexagon Bio raised? | Hexagon Bio has raised $256M across 5 funding rounds. |
| What was Hexagon Bio's last funding round? | Hexagon Bio's last funding round was a $62M Series C in October 2026, led by The Column Group. |
| Who are Hexagon Bio's investors? | Hexagon Bio's investors include 8VC, The Column Group, Nextech Invest, Two Sigma Ventures, CPP Investments, bpd partners, Deviation Capital, SoftBank Group, Casdin Capital, ATEL Growth Capital and 1 other. |
| Which companies are comparable to Hexagon Bio? | Companies comparable to Hexagon Bio include Geneplus-Beijing Co. Ltd., Valo Health, CureGenetics, Next Generation Gene Therapeutics, Scribe Therapeutics and Abclon. |
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