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- Gate Bioscience
Gate Bioscience Valuation, Funding & Investors
Gate Bioscience is valued at $161M as of November 2025.
Last Gate Bioscience valuation
$161M
Series B · Nov 2025
Last Gate Bioscience funding round
$65M
Series B · Nov 2025
Cumulative funding Gate Bioscience raised
$125M
across 2 funding rounds
Key investors in Gate Bioscience
Andreessen Horowitz
GV
ARCH Venture Partners
Versant Ventures
Eli Lilly
Forbion Capital Partners
About Gate Bioscience
Gate Bioscience is a biotechnology firm developing Molecular Gates, a class of small-molecule drugs that target the Sec61 translocon to block secretion of disease-causing proteins like VEGF and TGFβ. This approach triggers intracellular degradation of targets, offering potential oral therapies for cancers and fibrotic diseases. The company's Sec61 platform integrates a library of gatekeeper molecules with secretion-focused assays and expertise in the secretory pathway. Headquartered in San Francisco, Gate Bioscience raised Series A funding in 2022 to advance its lead candidates into clinical trials.
Founded
2021
HQ
Website
Status
Privately held
Customer focus
B2B
Revenue model
Licensing
Valuation
$161M (Nov 2025)
Sectors
Gate Bioscience Valuation
Gate Bioscience is currently valued at $161M, based on its Series B in November 2025.
The $65M round was led by Forbion Capital Partners, with participation from GV, Versant Ventures, Andreessen Horowitz, Eli Lilly and ARCH Venture Partners.
Gate Bioscience valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Nov 2025 | Series B | $161M |
Gate Bioscience Funding History
Gate Bioscience has raised a total of $125M across 2 funding rounds.
Gate Bioscience's first fundraising round was a $60M Series A in November 2023. The most recent completed round was a $65M Series B in November 2025.
Gate Bioscience funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Nov 2025 | Series B | Forbion Capital Partners (lead); GV; Versant Ventures; Andreessen Horowitz; Eli Lilly; ARCH Venture Partners | $65M | $161M | Gate Bioscience is a biotechnology company developing a novel class of small-molecule medicines called molecular gates, designed to eliminate disease-causing proteins at their source inside the cell. The company offers oral drug candidates targeting inflammatory and neurological diseases, positioning its approach as a pill-based alternative to injectable biologics. Gate Bioscience closed a $65 million oversubscribed Series B financing round on November 13, 2025, led by new investor Forbion Capital Partners B.V. The round included participation from new investor Eli Lilly and Company and existing backers Versant Ventures, Andreessen Horowitz Bio + Health, GV, and ARCH Venture Partners. This funding brought the company's total capital raised to approximately $135 million and valued the company at $161.0 million as of November 6, 2025. The Series B proceeds will fund advancement of Gate's lead molecular gate programs into clinical trials, expand its broader portfolio of molecular gate candidates, and strengthen its discovery platform. The company's platform has matured into a drug discovery engine enabling efficient generation of molecular gates for both internal development and partnerships with biopharma companies. Vanessa Carle, Principal at Forbion, joined Gate's Board of Directors as part of the transaction, bringing experience in scaling therapeutic companies across Europe and the United States. |
| Nov 2023 | Series A | Andreessen Horowitz (lead); Versant Ventures (lead); GV; ARCH Venture Partners | $60M | - | Gate Bioscience is a preclinical biotechnology company founded in 2021 and based in Brisbane, CA, developing a novel class of small molecule therapeutics called Molecular Gates. These drugs selectively bind to the secretory channel to block and degrade disease-causing extracellular proteins at their source inside the cell, targeting over 1,000 such proteins implicated in conditions like inflammation, neurodegenerative diseases, and cancers. The platform combines a proprietary library of Molecular Gates, secretion-focused assays, and insights into secretory pathway biology for high-throughput screening. In November 2023, Gate emerged from stealth with a $60 million Series A financing led by Versant Ventures and Andreessen Horowitz (a16z Bio + Health), with participation from ARCH Venture Partners and GV. The funds support advancing preclinical research, regulatory processes, platform expansion, and partnerships to move Molecular Gate medicines toward clinical stages. The company is led by experienced drug developers with track records in modalities like molecular glues, PROTACs, and covalent inhibitors. Gate has since raised a $65 million oversubscribed Series B in November 2025 led by Forbion with Eli Lilly and existing investors, bringing total capital to $135 million to fund IND-enabling studies, Phase 1 trials, and pipeline expansion in inflammation and beyond. In July 2024, Gate partnered with Eli Lilly in a deal worth up to $856 million in biobucks, including undisclosed upfront and equity for molecular gate programs. |
Who has invested in Gate Bioscience?
6 investors have backed Gate Bioscience across its funding rounds, including Andreessen Horowitz, GV, ARCH Venture Partners, Versant Ventures, Eli Lilly and Forbion Capital Partners.
Lead investors include Forbion Capital Partners, Andreessen Horowitz and Versant Ventures.
Gate Bioscience Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 2 | Participant | Nov 2023 | ||
| 2 | Lead | Nov 2023 | ||
| 2 | Lead | Nov 2023 | ||
| 2 | Participant | Nov 2023 | ||
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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
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Start Free TrialGate Bioscience Competitors
Gate Bioscience competitors include listed companies like Pyridam Farma and TYK Medicines, and private ones like Brainsgate, PlasmaGen Biosciences, 54gene and Maxwell Biosciences.
| Company | HQ | Status | Revenue | EBITDA | Valuation |
|---|---|---|---|---|---|
| Private | - | - | $161M | ||
| Private | - | - | $161M | ||
| Publicly listed | $156M | ($7M) | $161M | ||
| Publicly listed | - | ($40M) | $161M | ||
| Private | - | - | $162M | ||
| Private | - | - | $160M |
Gate Bioscience Public Comps
Gate Bioscience is still privately-owned, but its public comps include Pyridam Farma, TYK Medicines, Humacyte, Syn2bio, Atrium Therapeutics, Jagsonpal Pharma, Actinogen Medical, Outlook Therapeutics, Searle Co. and Nykode Therapeutics.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| $156M | ($7M) | 3.0x | - | (64.9x) | - | |||
| - | ($40M) | - | - | (3.9x) | - | |||
| $2M | ($25M) | 71.7x | 47.2x | (5.9x) | - | |||
| - | ($7M) | - | - | (21.2x) | - | |||
| $19M | ($77M) | - | - | - | - | |||
| $30M | $6M | 4.9x | - | 25.1x | - | |||
| $359K | ($11M) | 410.8x | 23.5x | (13.8x) | (19.7x) | |||
| $1M | ($64M) | 122.5x | 84.9x | (2.7x) | - | |||
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Common questions about Gate Bioscience
| When was Gate Bioscience founded? | Gate Bioscience was founded in 2021. |
| Where is Gate Bioscience headquartered? | Gate Bioscience is headquartered in United States. |
| Is Gate Bioscience publicly listed? | No, Gate Bioscience is a private, VC-backed company. |
| What is Gate Bioscience's valuation? | Gate Bioscience was last valued at $161M in its Series B in November 2025. |
| How much funding has Gate Bioscience raised? | Gate Bioscience has raised $125M across 2 funding rounds. |
| What was Gate Bioscience's last funding round? | Gate Bioscience's last funding round was a $65M Series B in November 2025, led by Forbion Capital Partners. |
| Who are Gate Bioscience's investors? | Gate Bioscience's investors include GV, Versant Ventures, Andreessen Horowitz, ARCH Venture Partners, Eli Lilly and Forbion Capital Partners. |
| Which companies are comparable to Gate Bioscience? | Companies comparable to Gate Bioscience include Brainsgate, PlasmaGen Biosciences, Pyridam Farma, TYK Medicines, 54gene and Maxwell Biosciences. |
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