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- Antiva Biosciences
Antiva Biosciences Valuation, Funding & Investors
Antiva Biosciences is valued at $92M as of November 2021.
Last Antiva Biosciences valuation
$92M
Series D · Nov 2021
Last Antiva Biosciences funding round
$53M
Series E · Apr 2023
Cumulative funding Antiva Biosciences raised
$140M
across 7 funding rounds
Key investors in Antiva Biosciences
Canaan Partners
Sofinnova Investments
Alexandria Venture Investments
OUP (Osage University Partners)
Lumira Ventures
Brace Pharma
About Antiva Biosciences
Antiva Biosciences is a biotechnology company developing topical treatments for disease caused by human papillomavirus. Its therapeutic development includes ABI-2280 for precancerous cervical lesions and high-risk HPV infections. The company is based in South San Francisco and advances clinical studies intended to provide alternatives to surgical management. Antiva was founded in 2012 by Karl Hostetler of the University of California, San Diego, and raised a $31 million Series D financing in November 2021. The financing supported advancement of ABI-2280 into early clinical trials for high-grade cervical intraepithelial lesions. Its therapeutic strategy aims to treat precancerous tissue locally and provide an alternative to surgical procedures that can affect reproductive health. In April 2023 it announced a further $53 million financing and appointed Kristine Ball as chief executive to support the next stage of development.
Founded
2012
HQ
Website
Status
Privately held
Customer focus
B2B
Revenue model
Product sales
Valuation
$92M (Nov 2021)
Sectors
Antiva Biosciences Valuation
Antiva Biosciences is currently valued at $92M, based on its Series D in November 2021. Read the announcement ↗
The $31M round was led by Adjuvant Capital and HBM Healthcare Investments, with participation from Sirona Capital, Canaan Partners, GV, Lumira Ventures, Alexandria Venture Investments and 7 other investors.
Antiva Biosciences valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Nov 2021 | Series D | $92M |
Antiva Biosciences Funding History
Antiva Biosciences has raised a total of $140M across 7 funding rounds.
Antiva Biosciences' first fundraising round was a $1M seed round in March 2013. The most recent completed round was a $53M Series E in April 2023.
Antiva Biosciences funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Apr 2023 | Series E | BioImpact Capital (lead); Adjuvant Capital; Canaan Partners; GV; Lumira Ventures; HBM Partners; Sofinnova Investments | $53M | - | Antiva Biosciences is a biopharmaceutical company developing novel, topical therapeutics for pre-cancerous lesions caused by human papillomavirus (HPV) infection. Its lead candidate, ABI-2280, is a vaginal tablet with potent antiviral activity across all HPV serotypes, blocking replication and inducing apoptosis in infected lesions while sparing normal cells, enabling self-administration. On April 27, 2023, Antiva closed a $53 million Series E equity financing led by MPM-BioImpact Capital, with participation from existing investors including Canaan Partners, Sofinnova Investments, Adjuvant Capital, GV, and Lumira Ventures. The round also brought new board members: Kristine Ball as CEO (succeeding Gail Maderis, who became chair), and Florencia Segal, M.D., and Brian Goodman, Ph.D., from MPM-BioImpact Capital. Proceeds will fund ABI-2280 into late 2025, supporting Phase 2 trials in high-grade cervical intraepithelial neoplasia (CIN 2/3) and exploratory studies for high-risk HPV infections that lead to cancer, advancing the WHO's screen-and-treat approach. Antiva focuses on unmet needs in HPV-related indications with potential for global health impact. |
| Nov 2021 | Series D | Adjuvant Capital (lead); HBM Healthcare Investments (lead); Sirona Capital; Canaan Partners; GV; Lumira Ventures; Alexandria Venture Investments; Dong-A ST; Gaingels; Mana Ventures; Sofinnova Investments; Avestria Ventures; Brace Pharma; OUP (Osage University Partners) | $31M | $92M | Antiva Biosciences is a South San Francisco-based biopharmaceutical company developing novel topical therapeutics for treating pre-cancerous lesions caused by human papillomavirus (HPV) infection. The company's lead development candidate is ABI-2280, designed to prevent cervical lesions from progressing to cancer. On November 2, 2021, Antiva closed a $31 million Series D equity financing led by Adjuvant Capital, a women's health-focused venture firm backed by the Bill & Melinda Gates Foundation. The round included participation from GV (formerly Google Ventures), HBM Healthcare Investments, Avestria Ventures, Gaingels, Mana Ventures, and existing investors Canaan Partners, Sofinnova Ventures, Lumira Ventures, and others. Post-money valuation at the time of the Series D was estimated between $92 million and $123 million. Proceeds were designated to support continued development of ABI-2280, including advancement into Phase 1 clinical trials. The financing timing coincided with the company's progression toward first-in-human clinical testing. |
| Jul 2018 | Series C | Hillhouse Investment (lead); Sirona Capital (lead); Canaan Partners; Lumira Ventures; Alexandria Venture Investments; JLABS; Sofinnova Investments; NS Investment; Brace Pharma; OUP (Osage University Partners) | $15M | - | Antiva Biosciences raised $15 million in a Series C-1 financing round on July 10, 2018, led by Hillhouse Capital Management with participation from Sirona Capital and existing investors Canaan Partners, Sofinnova Ventures, Brace Pharma Capital, Osage University Partners, and Lumira Capital. The funds supported additional clinical studies for ABI-1968, a topical therapeutic for pre-cancerous lesions caused by HPV infection, including Phase 1b trials in high-grade cervical intraepithelial neoplasia (CIN 2,3) and anal intraepithelial neoplasia (AIN 2,3). Hillhouse appointed a representative to Antiva’s board of directors. |
| Mar 2017 | Series C | Brace Pharma (lead); Canaan Partners; Alexandria Venture Investments; Sofinnova Investments; NS Investment; OUP (Osage University Partners) | $22M | - | Antiva Biosciences, a clinical-stage biopharmaceutical company based in South San Francisco, develops novel topical therapeutics for pre-cancerous lesions caused by human papillomavirus (HPV) infection, such as high-grade cervical intraepithelial neoplasia (CIN) and anal intraepithelial neoplasia (AIN). The company's lead candidate, ABI-1968, was in Phase 1b clinical studies with results expected by year-end 2018. Founded in 2012 based on research by Dr. Karl Hostetler from the University of California San Diego, Antiva had previously raised $16 million in a Series B round in 2015 led by Canaan Partners and Sofinnova Ventures, following $4 million from undisclosed backers in 2013-2014. On March 28, 2017, Antiva closed a $22 million Series C financing led by Brace Pharma Capital, with participation from new investors NS Investment, Osage University Partners (OUP), and Alexandria Venture Investments, alongside existing investors Canaan Partners and Sofinnova Ventures (noted as Sofinnova Investments in later contexts). The funding supported ongoing development of its topical antivirals, including plans for head and neck cancer applications. Subsequent rounds included a $15 million Series C-1 in July 2018 led by Hillhouse Capital Management, bringing total funding to $57 million and enabling additional clinical trials and Phase 2 preparations for 2019. A $31 million Series D in November 2021 was led by Adjuvant Capital with GV and others, advancing ABI-2280 toward Phase 1 trials. Later, a $53 million Series E in April 2023 led by MPM-BioImpact Capital funded Phase 2 studies for ABI-2280 in CIN 2/3 and high-risk HPV. |
| Aug 2015 | Series B | Canaan Partners; Sofinnova Investments; Wende Hutton | $16M | - | - |
| Dec 2014 | Seed | - | $2M | - | - |
| Mar 2013 | Seed | - | $1M | - | - |
Who has invested in Antiva Biosciences?
20 investors have backed Antiva Biosciences across its funding rounds, including Canaan Partners, Sofinnova Investments, Alexandria Venture Investments, OUP (Osage University Partners), Lumira Ventures and Brace Pharma.
Lead investors include BioImpact Capital, Adjuvant Capital, HBM Healthcare Investments, Hillhouse Investment, Sirona Capital and 1 other investor.
Antiva Biosciences Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 5 | Participant | Aug 2015 | ||
| 5 | Participant | Aug 2015 | ||
| 3 | Participant | Jul 2018 | ||
| 3 | Participant | Mar 2017 | ||
| 3 | Lead | Mar 2017 | ||
| 3 | Participant | Mar 2017 | ||
| 2 | Lead | Jul 2018 | ||
| 2 | Lead | Nov 2021 | ||
| 2 | Participant | Nov 2021 | ||
| 2 | Participant | Mar 2017 | ||
| 1 | Lead | Nov 2021 | ||
| 1 | Lead | Jul 2018 | ||
| 1 | Participant | Nov 2021 | ||
This data is available for Pro users. Sign up to see all 20 Antiva Biosciences investors. Start Free Trial | ||||
Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
Sign up to see data on 350K+ funding rounds and disclosed revenue and EBITDA valuation multiples, from seed, through growth stage, to pre-IPO.
Start Free TrialAntiva Biosciences Competitors
Antiva Biosciences competitors include listed companies like Rallybio, IBT and Fractyl Health, and private ones like Dyve Biosciences, Novadip Biosciences and Vivace Therapeutics.
| Company | HQ | Status | Revenue | EBITDA | Valuation |
|---|---|---|---|---|---|
| Private | - | - | $93M | ||
| Publicly listed | $858K | ($11M) | $91M | ||
| Private | - | - | $93M | ||
| Publicly listed | - | ($7M) | $91M | ||
| Publicly listed | - | ($141M) | $94M | ||
| Private | - | - | $90M |
Antiva Biosciences Public Comps
Antiva Biosciences is still privately-owned, but its public comps include Rallybio, IBT, Fractyl Health, AlzeCure Pharma, ImmuCell, Ensol Biosciences, Faron Pharmaceuticals, Island Pharmaceuticals, Anixa Biosciences and Vistin Pharma.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| $858K | ($11M) | - | - | - | - | |||
| - | ($7M) | - | - | (11.4x) | (6.8x) | |||
| - | ($141M) | - | - | (0.8x) | (1.4x) | |||
| - | ($5M) | - | 7.3x | (19.6x) | 17.7x | |||
| $28M | $2M | 3.4x | - | 47.0x | - | |||
| $18K | ($3M) | 4131.4x | - | (25.0x) | - | |||
| - | ($30M) | - | 733.7x | (2.7x) | (3.1x) | |||
| $201K | ($7M) | 394.4x | 253.6x | (11.1x) | (12.1x) | |||
This data is available for Pro users. Sign up to see all Antiva Biosciences competitors and their valuation data. Start Free Trial | ||||||||
Common questions about Antiva Biosciences
| When was Antiva Biosciences founded? | Antiva Biosciences was founded in 2012. |
| Where is Antiva Biosciences headquartered? | Antiva Biosciences is headquartered in South San Francisco, United States. |
| Is Antiva Biosciences publicly listed? | No, Antiva Biosciences is a private, VC-backed company. |
| What is Antiva Biosciences' valuation? | Antiva Biosciences was last valued at $92M in its Series D in November 2021. |
| How much funding has Antiva Biosciences raised? | Antiva Biosciences has raised $140M across 7 funding rounds. |
| What was Antiva Biosciences' last funding round? | Antiva Biosciences' last funding round was a $53M Series E in April 2023, led by BioImpact Capital. |
| Who are Antiva Biosciences' investors? | Antiva Biosciences' investors include Canaan Partners, Sofinnova Investments, Lumira Ventures, Alexandria Venture Investments, Brace Pharma, OUP (Osage University Partners), Sirona Capital, Adjuvant Capital, GV, NS Investment and 10 others. |
| Which companies are comparable to Antiva Biosciences? | Companies comparable to Antiva Biosciences include Dyve Biosciences, Rallybio, Novadip Biosciences, IBT, Fractyl Health and Vivace Therapeutics. |
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