About Aliada Therapeutics
Aliada Therapeutics is a Boston-headquartered biotechnology firm developing novel therapies for central nervous system diseases. Its proprietary platform creates antibody-based binders targeting specific CNS proteins, advancing multiple programs from preclinical evaluation toward clinical trials for neurological disorders.
Founded
2021
HQ
Website
Status
Acquired
Customer focus
B2B
Revenue model
Product sales
Valuation
$1.4B (acquired Oct 2024)
Sectors
Aliada Therapeutics Acquisition
Aliada Therapeutics was acquired by AbbVie for $1.4B on 28 October 2024.
Before the acquisition Aliada Therapeutics had raised $32M across 1 funding round.
Aliada Therapeutics, a Boston-based biotechnology company founded in 2021, develops therapies for central nervous system diseases using its proprietary MODEL platform, a novel blood-brain barrier-crossing technology that enables low-volume subcutaneous delivery of therapeutics into the brain by attaching them to carrier molecules that bind to transport proteins. The company's lead asset, ALIA-1758, is an anti-pyroglutamate amyloid beta (3pE-Aβ) antibody in Phase 1 clinical trials for Alzheimer's disease, targeting stable, clumping forms of amyloid beta proteins linked to disease pathology. Aliada in-licensed technology from Johnson & Johnson and received seed funding from J&J's venture arm and RA Capital Management, which incubated the company through its Raven program. AbbVie, a global biopharmaceutical company, acquired Aliada for $1.4 billion in cash, purchasing all outstanding equity subject to customary adjustments. The deal was announced on October 28, 2024, with an expected close in Q4 2024, and completed on December 11, 2024, following regulatory approvals. This marks the second major exit from RA Capital's Raven incubator that year, after Novartis' $1 billion acquisition of Mariana Oncology. AbbVie views the acquisition as strengthening its neuroscience pipeline, a key growth area, by adding ALIA-1758 as a potential best-in-class Alzheimer's therapy and the MODEL platform to enhance CNS drug delivery across neurological disorders. The move follows AbbVie's termination of its internal anti-amyloid antibody ABBV-916 after Phase 2 data showed it was undifferentiated from approved drugs, positioning ALIA-1758 for potential superiority via improved brain penetration. It also intensifies competition with Denali Therapeutics in blood-brain barrier technology.
| Acquirer | Date | Type | Price |
|---|---|---|---|
| 28 Oct 2024 | PE buyout | $1.4B |
Aliada Therapeutics Funding History
Aliada Therapeutics has raised a total of $32M across 1 funding round.
Aliada Therapeutics funding rounds
| Date | Stage | Raised | Deal Summary |
|---|---|---|---|
| Dec 2022 | Undisclosed stage | $32M | Aliada Therapeutics raised $32M in a Seed VC round on December 30, 2022, led by OrbiMed Advisors, as part of its total funding of $33M across three rounds including earlier Seed and Debt financings. The company, founded in 2018 and headquartered in South San Francisco (with some references to Boston), focuses on biotechnology developing therapies for central nervous system (CNS) diseases using a novel blood-brain barrier (BBB)-crossing technology platform called MODEL, originally licensed from Johnson & Johnson scientists. Co-founded by Johnson & Johnson Innovation – JJDC, RA Capital, and RA Capital's Raven incubator, which co-led the series seed financing in 2021. Aliada's lead asset, ALIA-1758, is an anti-pyroglutamate amyloid beta (3pE-Aβ) antibody in Phase 1 clinical trials for Alzheimer's disease, leveraging the BBB platform for enhanced drug delivery to the brain. The company had grown to over 90 employees by the time of its later acquisition. No revenue, ARR, EBITDA, valuation, or traction metrics like user counts or other financials are reported for the 2022 round or near that period; sources explicitly list revenue as '0 FY undefined'. In October 2024, AbbVie agreed to acquire Aliada for $1.4 billion in cash, closing in December 2024, marking a significant exit for investors including RA Capital's second Raven portfolio company acquisition that year after Mariana Oncology. The deal was for all outstanding equity, subject to adjustments, to advance ALIA-1758 and the BBB platform, distinguishing it from competitors like Eli Lilly's Kisunla by superior brain penetration. No competitive landscape or market context beyond CNS focus is detailed, and the 2022 VC round lacks any disclosed post-money valuation or multiples. |
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Start Free TrialAliada Therapeutics Competitors
Aliada Therapeutics competitors include listed companies like First Tracks Biotherapeutics, ArriVent BioPharma, Phibro Animal Health and Pacific Shuanglin, and private ones like Moonlight Therapeutics and Grupo Cimed.
| Company | HQ | Status | Revenue | EBITDA | Valuation | Revenue Multiple |
|---|---|---|---|---|---|---|
| Private | - | - | $1.4B | - | ||
| Publicly listed | - | ($179M) | $1.4B | - | ||
| Publicly listed | - | ($178M) | $1.4B | - | ||
| Publicly listed | $1.5B | $231M | $1.4B | 1.4x | ||
| Publicly listed | $393M | $90M | $1.4B | - | ||
| Private | - | - | $1.4B | - |
Aliada Therapeutics Public Comps
Aliada Therapeutics is no longer listed, but its public comps include First Tracks Biotherapeutics, ArriVent BioPharma, Phibro Animal Health, Pacific Shuanglin, Damora Therapeutics, SOTHEMA, Zhejiang Jolly, Cullinan Therapeutics, Ascentage Pharma Group and Ultragenyx.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| - | ($179M) | - | - | (6.9x) | (7.6x) | |||
| - | ($178M) | - | - | (5.8x) | (5.2x) | |||
| $1.5B | $231M | 1.4x | 1.4x | 9.1x | 8.2x | |||
| $393M | $90M | 3.6x | - | 15.8x | - | |||
| - | ($211M) | - | - | (4.7x) | (6.1x) | |||
| $340M | $75M | 4.3x | 4.2x | 19.6x | - | |||
| $453M | $126M | 3.1x | 2.7x | 11.2x | 10.4x | |||
| - | ($242M) | - | 115.6x | (4.3x) | (5.0x) | |||
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Common questions about Aliada Therapeutics
| When was Aliada Therapeutics founded? | Aliada Therapeutics was founded in 2021. |
| Where is Aliada Therapeutics headquartered? | Aliada Therapeutics is headquartered in Boston, MA, United States. |
| Is Aliada Therapeutics publicly listed? | No, Aliada Therapeutics was acquired by AbbVie in October 2024. |
| Who acquired Aliada Therapeutics? | Aliada Therapeutics was acquired by AbbVie in October 2024. |
| How much was Aliada Therapeutics acquired for? | Aliada Therapeutics was acquired for $1.4B in October 2024. |
| How much funding has Aliada Therapeutics raised? | Aliada Therapeutics has raised $32M across 1 funding round. |
| What was Aliada Therapeutics' last funding round? | Aliada Therapeutics' last funding round was a $32M undisclosed-stage round in December 2022. |
| Which companies are comparable to Aliada Therapeutics? | Companies comparable to Aliada Therapeutics include Moonlight Therapeutics, First Tracks Biotherapeutics, ArriVent BioPharma, Phibro Animal Health, Pacific Shuanglin and Grupo Cimed. |
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