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- Aeovian Pharmaceuticals
Aeovian Pharmaceuticals Valuation, Funding & Investors
Aeovian Pharmaceuticals is valued at $172M as of December 2025.
Last Aeovian Pharmaceuticals valuation
$172M
Series B · Dec 2025
Last Aeovian Pharmaceuticals funding round
$55M
Series B · Dec 2025
Cumulative funding Aeovian Pharmaceuticals raised
$142M
across 3 funding rounds
Key investors in Aeovian Pharmaceuticals
Sofinnova Investments
venBio Partners
Apollo Health Ventures
Evotec
Hevolution
b2venture
About Aeovian Pharmaceuticals
Aeovian Pharmaceuticals is a San Francisco Bay Area-headquartered biopharmaceutical company developing small-molecule therapeutics for rare and age-related diseases. The firm targets pathways involving oxidative stress and mitochondrial dysfunction with lead candidates in preclinical stages for conditions like ALS and Parkinson's. Founded in 2012, Aeovian Pharmaceuticals advances compounds modulating NAD+ salvage pathways to restore cellular energy metabolism and halt disease progression.
Founded
2012
HQ
Website
Status
Privately held
Customer focus
B2C
Revenue model
Product sales
Valuation
$172M (Dec 2025)
Sectors
Aeovian Pharmaceuticals Valuation
Aeovian Pharmaceuticals is currently valued at $172M, based on its Series B in December 2025.
The $55M round was led by CTI Life Sciences Fund and Luma Group, with participation from The TSC Alliance Endowment Fund, Foresite Capital, venBio Partners, Sofinnova Investments, Apollo Health Ventures and 2 other investors.
Aeovian Pharmaceuticals valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Dec 2025 | Series B | $172M |
Aeovian Pharmaceuticals Funding History
Aeovian Pharmaceuticals has raised a total of $142M across 3 funding rounds.
Aeovian Pharmaceuticals' first fundraising round was a $37M Series A in October 2019. The most recent completed round was a $55M Series B in December 2025.
Aeovian Pharmaceuticals funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Dec 2025 | Series B | CTI Life Sciences Fund (lead); Luma Group (lead); The TSC Alliance Endowment Fund; Foresite Capital; venBio Partners; Sofinnova Investments; Apollo Health Ventures; Hevolution; Wilson Sonsini Goodrich & Rosati | $55M | $172M | Aeovian Pharmaceuticals is a Berkeley-based clinical-stage biopharmaceutical company developing highly selective small molecule therapeutics focused on restoring cellular metabolic quality control. The company's lead candidate, AV078, is a CNS-penetrant selective mTORC1 inhibitor designed to treat tuberous sclerosis complex (TSC)-related refractory epilepsy, with a broader pipeline targeting rare diseases and age-related conditions driven by similar biological mechanisms. On December 16, 2025, Aeovian closed an oversubscribed $55 million Series B financing round co-led by Luma Group and CTI Life Sciences Fund, with participation from new investors Foresite Capital, SymBiosis, the TSC Alliance Endowment Fund, and Wilson Sonsini, alongside existing investors Apollo Health Ventures, Hevolution, Sofinnova Investments, and venBio. The funding will accelerate development of AV078 and support completion of its Phase 2 proof-of-concept study. As part of the Series B, Themasap Khan, Ph.D., co-founder and partner at Luma Group, and Youssef Bennani, Ph.D., managing partner at CTI Life Sciences, joined the Board of Directors. The company was valued at $172.0 million as of December 15, 2025, having raised a total of $143.2 million across multiple rounds since inception. |
| Mar 2024 | Series A | Hevolution (lead); Evotec; b2venture; venBio Partners; Sofinnova Investments; Apollo Health Ventures | $50M | - | Aeovian Pharmaceuticals is a clinical-stage biopharmaceutical company developing highly selective small molecule therapeutics that restore cellular metabolic quality control, focusing on selective mTORC1 inhibitors for diseases like TSC refractory epilepsy, neurological diseases, and prevalent diseases of aging. On March 28, 2024, Hevolution Foundation announced a $20 million impact investment as the lead in a $50 million Series A financing extension, joined by Apollo Health Ventures, Sofinnova Investments, venBio Partners, Evotec, and b2venture. Hevolution's Chief Investment Officer, Dr. William Greene, joined Aeovian's Board of Directors to support growth. The funds support advancing the platform, including completion of a Phase 1 clinical trial in healthy volunteers and preparation for a Phase 2 trial in TSC refractory epilepsy patients. This extension followed an initial Series A and preceded a later $55 million oversubscribed Series B in December 2025, co-led by Luma Group and CTI Life Sciences Fund, with participation from Foresite Capital, SymBiosis, TSC Alliance Endowment Fund, Wilson Sonsini, and existing investors including Apollo Health Ventures, Hevolution, Sofinnova Investments, and venBio. The Series B funds completion of a Phase 2 proof-of-concept study for lead candidate AV078, a CNS-penetrant selective mTORC1 inhibitor, in TSC-related refractory epilepsy. Aeovian had dosed the first cohort in the Phase 1 trial around the Series A extension time. |
| Oct 2019 | Series A | Apollo Health Ventures (lead); Sofinnova Investments (lead); venBio Partners (lead); Evotec | $37M | - | Aeovian Pharmaceuticals, a San Francisco-based biotech company founded in 2012, develops innovative small-molecule therapies targeting the mTORC1 pathway to treat rare and age-related diseases, including CNS disorders like tuberous sclerosis complex (TSC)-related epilepsy. The company's lead selective mTORC1 inhibitor, initially AE116 and later AV078, aims to avoid side effects of existing inhibitors by sparing mTORC2, with potential applications in neurodegenerative diseases, sarcopenia, frailty, and anti-aging studies. Its platform, supported by IP from the Buck Institute, focuses on restoring cellular metabolic quality control. In October 2019, Aeovian closed a $37 million Series A financing round co-led by venBio Partners and Sofinnova Investments, with participation from Apollo Health Ventures and Evotec SE. Proceeds funded advancement of the lead candidate through IND-enabling studies into clinical development for an undisclosed rare CNS disease. New board members included Richard Gaster and Yvonne Yamanaka from venBio, Mike Powell and Sarah Bhagat from Sofinnova, and Jens Eckstein from Apollo. Later developments included a $50 million follow-on tranche in March 2024 from returning investors plus Hevolution Foundation, bringing total funding to $87 million, and a $55 million oversubscribed Series B in December 2025 to support Phase II trials for TSC-related refractory epilepsy. |
Who has invested in Aeovian Pharmaceuticals?
11 investors have backed Aeovian Pharmaceuticals across its funding rounds, including Sofinnova Investments, venBio Partners, Apollo Health Ventures, Evotec, Hevolution and b2venture.
Lead investors include CTI Life Sciences Fund, Luma Group, Hevolution, Apollo Health Ventures, Sofinnova Investments and 1 other investor.
Aeovian Pharmaceuticals Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 3 | Lead | Oct 2019 | ||
| 3 | Lead | Oct 2019 | ||
| 3 | Lead | Oct 2019 | ||
| 2 | Participant | Oct 2019 | ||
| 2 | Lead | Mar 2024 | ||
| 1 | Participant | Dec 2025 | ||
| 1 | Participant | Mar 2024 | ||
| 1 | Lead | Dec 2025 | ||
| 1 | Participant | Dec 2025 | ||
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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
Sign up to see data on 350K+ funding rounds and disclosed revenue and EBITDA valuation multiples, from seed, through growth stage, to pre-IPO.
Start Free TrialAeovian Pharmaceuticals Competitors
Aeovian Pharmaceuticals competitors include listed companies like MediWound, Huons Co, MediciNova and Organogenesis, and private ones like BlissBio and QureBio.
| Company | HQ | Status | Revenue | EBITDA | Valuation | Revenue Multiple |
|---|---|---|---|---|---|---|
| Publicly listed | $17M | ($23M) | $172M | 6.7x | ||
| Publicly listed | $452M | $58M | $170M | - | ||
| Private | - | - | $174M | - | ||
| Private | - | - | $174M | - | ||
| Publicly listed | $410K | ($13M) | $170M | 288.9x | ||
| Publicly listed | $563M | $72M | $175M | 1.1x |
Aeovian Pharmaceuticals Public Comps
Aeovian Pharmaceuticals is still privately-owned, but its public comps include MediWound, Huons Co, MediciNova, Organogenesis, Biomm, Mayne Pharma Group, Nykode Therapeutics, Nextbiomedical Co, IMBiologics and Searle Co..
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| $17M | ($23M) | 8.6x | 6.7x | (6.2x) | (5.1x) | |||
| $452M | $58M | 0.6x | - | 4.6x | - | |||
| $410K | ($13M) | 352.8x | 288.9x | (10.9x) | (9.8x) | |||
| $563M | $72M | 0.6x | 1.1x | 4.7x | (8.0x) | |||
| $52M | $370K | 3.7x | - | 526.5x | - | |||
| $269M | $57M | 0.6x | 0.5x | 2.7x | 6.2x | |||
| - | ($19M) | - | - | (6.4x) | (3.9x) | |||
| $12M | ($256K) | 13.1x | 11.5x | (611.8x) | (44.5x) | |||
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Common questions about Aeovian Pharmaceuticals
| When was Aeovian Pharmaceuticals founded? | Aeovian Pharmaceuticals was founded in 2012. |
| Where is Aeovian Pharmaceuticals headquartered? | Aeovian Pharmaceuticals is headquartered in San Francisco, CA, United States. |
| Is Aeovian Pharmaceuticals publicly listed? | No, Aeovian Pharmaceuticals is a private, VC-backed company. |
| What is Aeovian Pharmaceuticals' valuation? | Aeovian Pharmaceuticals was last valued at $172M in its Series B in December 2025. |
| How much funding has Aeovian Pharmaceuticals raised? | Aeovian Pharmaceuticals has raised $142M across 3 funding rounds. |
| What was Aeovian Pharmaceuticals' last funding round? | Aeovian Pharmaceuticals' last funding round was a $55M Series B in December 2025, led by CTI Life Sciences Fund and Luma Group. |
| Who are Aeovian Pharmaceuticals' investors? | Aeovian Pharmaceuticals' investors include venBio Partners, Sofinnova Investments, Apollo Health Ventures, Evotec, Hevolution, The TSC Alliance Endowment Fund, b2venture, Luma Group, Foresite Capital, CTI Life Sciences Fund and 1 other. |
| Which companies are comparable to Aeovian Pharmaceuticals? | Companies comparable to Aeovian Pharmaceuticals include MediWound, Huons Co, BlissBio, QureBio, MediciNova and Organogenesis. |
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