OncoResponse Valuation, Funding & Investors

OncoResponse is valued at $106M as of September 2018.

Last OncoResponse valuation

$106M

Series B · Sep 2018

Last OncoResponse funding round

$14M

Series D · May 2023

Cumulative funding OncoResponse raised

$117M

across 6 funding rounds

Key investors in OncoResponse

  • Canaan Partners
  • ARCH Venture Partners
  • 3B Future Health Fund
  • RiverVest
  • Alexandria Venture Investments
  • Redmile Group

OncoResponse Overview

About OncoResponse

OncoResponse is an immuno-oncology company employing a human antibody discovery platform to target immunosuppressive myeloid cells in the tumor microenvironment. Its antibodies, such as those against CD73 and TIGIT, aim to enhance T-cell activation in solid tumors. Headquartered in Boston, Massachusetts, and founded in 2015, the firm raised over $100 million in funding from ARCH Venture Partners and others. OncoResponse advances multiple candidates into preclinical development for cold tumor conversion.


Founded

2016

HQ

United StatesSeattle, WA

Status

Privately held

Customer focus

B2B

Revenue model

Licensing

Valuation

$106M (Sep 2018)

OncoResponse Valuation

OncoResponse is currently valued at $106M, based on its Series B in September 2018.

The $40M round was led by RiverVest, with participation from Canaan Partners, Redmile Group, Alexandria Venture Investments, Qatar Investment Authority, 3B Future Health Fund and 3 other investors.

OncoResponse valuation by funding round

OncoResponse valuation by funding round
DateStageValuation
Sep 2018Series B$106M

OncoResponse Funding History

OncoResponse has raised a total of $117M across 6 funding rounds.

OncoResponse's first fundraising round was a $13M Series A in May 2016. The most recent completed round was a $14M Series D in May 2023.

OncoResponse funding rounds

OncoResponse funding rounds
DateStageInvestorsRaisedValuationDeal Summary
May 2023Series DRiverVest (lead); Canaan Partners; Takeda Ventures; 3B Future Health Fund; Bering Capital; InterVest Co.; ARCH Venture Partners$14M-OncoResponse is a clinical-stage immuno-oncology biotech company developing cancer immunotherapies by identifying novel antibodies from patients with elite responses to cancer treatments. The company operates through a proprietary B-cell discovery platform developed in strategic alliance with MD Anderson Cancer Center, targeting immune cells in the tumor microenvironment. OncoResponse's lead candidates include OR502 and OR2805, fully human monoclonal antibodies designed to modulate immunosuppression. In May 2023, the company raised $14 million in Series D equity financing led by RiverVest Venture Partners alongside co-investors including ARCH Venture Partners, Canaan Partners, 3B Future Health Fund, Bering Capital, Takeda Ventures, and InterVest. Simultaneously, OncoResponse secured a $13 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to support advancement of OR502 toward investigational new drug status and clinical trials. The company uses its discovery engine to rapidly identify therapeutically relevant antibody candidates across multiple cancer types, positioning itself to expand immunotherapy treatment options for cancer patients.
Mar 2021Series CMagnetar Capital (lead); Canaan Partners; Redmile Group; Qatar Investment Authority; 3B Future Health Fund; Yonjin Venture; Bering Capital; RiverVest; ARCH Venture Partners$41M-OncoResponse, a Seattle-based biotechnology company spun out from MD Anderson Cancer Center and Theraclone Sciences in 2015, develops fully human antibodies derived from the immune systems of cancer patients who responded well to immunotherapies. The company's proprietary screening platform identifies antibodies that modulate immune cells in the tumor microenvironment to enhance immune activation and tumor killing, with its lead candidate OR2805 targeting immunosuppressive myeloid cells for cancer immunotherapy. On March 31, 2021, OncoResponse raised $40.6 million in a Series C financing round led by Magnetar Capital (Magnetar Group), with participation from new investors Yonjin Venture and Bering Capital, alongside existing investors including RiverVest Venture Partners, Qatar Investment Authority, Redmile Group, 3B Future Health Fund (Helsinn Investment Fund), Canaan Partners, and ARCH Venture Partners. The proceeds fund advancement of OR2805 into Phase 1 and 2 clinical studies across multiple tumor types and support a pipeline of preclinical assets toward IND. Ted Koutouzis from Magnetar, Daguang Wang from Yonjin Venture, and Patrick Hojlo from QIA joined the board. By 2021, OncoResponse had raised nearly $110 million total, advancing toward clinical trials with OR2805 entering studies in summer 2021. The company operates in the competitive cancer immunotherapy space, focusing on overcoming resistance to existing treatments by targeting tumor microenvironment immunosuppression.
Sep 2018Series BRiverVest (lead); Canaan Partners; Redmile Group; Alexandria Venture Investments; Qatar Investment Authority; 3B Future Health Fund; Rice University; ARCH Venture Partners; HT Capital$40M$106MOncoResponse is a Seattle-based immunotherapy company founded in 2016 that develops novel antibodies derived from the immune systems of cancer patients who responded exceptionally well to immunotherapies. The company leverages a proprietary B-cell technology platform, in alliance with MD Anderson Cancer Center, to discover therapeutic monoclonal antibodies targeting high-value cancer targets, particularly those modulating immunosuppression in the tumor microenvironment. Its portfolio includes multiple drug candidates advancing from discovery to preclinical and clinical development. On September 11, 2018, OncoResponse completed a $40 million Series B equity financing round led by RiverVest Venture Partners, matching the query's investors including Qatar Investment Authority, Redmile Group, Alexandria Venture Investments, ARCH Venture Partners, Canaan Partners, HT Family Office (likely HT Capital), and William Marsh Rice University. The proceeds were designated to advance five drug candidates into preclinical and clinical stages, transitioning the company from target identification to patient-focused development. CEO Clifford J. Stocks, with prior experience at Theraclone Sciences and ICOS Corporation, highlighted the addition of strong syndicate investors to support this shift. RiverVest's John McKearn praised the platform's rapid screening capabilities and the potential of the unique drug candidates to expand immunotherapy's promise.
Mar 2017Series A-$3M-OncoResponse is a biotechnology company that mines the human immune system to discover and develop therapeutic monoclonal antibodies for cancer immunotherapy. The company's I-STAR technology platform identifies antibodies from the immune systems of patients who have responded exceptionally well to cancer immunotherapies, with research developed in partnership with MD Anderson Cancer Center. OncoResponse announced the final closing of its Series A financing at $22.5 million in March 2017, which followed an initial closing in October 2015. The company's focus areas included melanoma, non-small cell lung cancer, prostate cancer, gastric cancer, and chronic myeloid leukemia, with plans to advance five antibody programs into preclinical and clinical development.
Oct 2016Series A3B Future Health Fund (lead); GreatPoint Ventures (lead)$7M-OncoResponse, an immuno-oncology antibody discovery company based in Houston, Texas, raised $7 million in a supplemental Series A financing on October 10, 2016. The round consisted of $3.5 million from GreatPoint Ventures and $3.5 million from the Helsinn Investment Fund. This brought the total Series A financing to $19.5 million, including a prior $3 million investment from Baxalta (now Shire) in May 2016, toward a supplemental goal of $10 million with an expected total raise of $22.5 million. The funds supported OncoResponse’s efforts to interrogate the humoral response of elite responders to cancer immunotherapy, aiming to identify antibodies and potential targets for novel therapeutic development in various oncology indications. GreatPoint Ventures, a thesis-driven venture capital firm investing in innovative solutions to global problems, highlighted OncoResponse’s pioneering approach to novel target and antibody discovery from elite responders.
May 2016Series AARCH Venture Partners (lead); Baxalta (lead); Canaan Partners; Alexandria Venture Investments; The University of Texas M.D. Anderson Cancer Center; Rice University$13M-OncoResponse is an immuno-oncology antibody discovery company spun out from MD Anderson Cancer Center, utilizing a platform to screen antibodies from elite cancer immunotherapy responders for novel targets and therapeutics. The company collaborates with MD Anderson for patient samples and expertise. In October 2015, OncoResponse closed an initial Series A financing of $9.5 million co-led by ARCH Venture Partners, Canaan Partners, and MD Anderson, with participation from William Marsh Rice University and Alexandria Real Estate Equities. In May 2016, Baxalta invested an additional $3 million. By October 2016, GreatPoint Ventures and Helsinn Investment Fund each contributed $3.5 million in supplemental Series A funding, bringing the total Series A to $19.5 million toward a $22.5 million goal. Funds supported interrogation of humoral responses in elite responders to identify antibodies and targets.

Who has invested in OncoResponse?

17 investors have backed OncoResponse across its funding rounds, including Canaan Partners, ARCH Venture Partners, 3B Future Health Fund, RiverVest, Alexandria Venture Investments and Redmile Group.

Lead investors include RiverVest, Magnetar Capital, 3B Future Health Fund, GreatPoint Ventures, ARCH Venture Partners and 1 other investor.


OncoResponse Investors

Investors in OncoResponse by funding rounds participated
InvestorHQRoundsRoleFirst check
Canaan PartnersUnited StatesUnited States4ParticipantMay 2016
3B Future Health FundGermanyGermany4LeadOct 2016
ARCH Venture PartnersUnited StatesChicago, IL4LeadMay 2016
RiverVestUnited StatesUnited States3LeadSep 2018
Redmile GroupUnited StatesSan Francisco, CA2ParticipantSep 2018
Alexandria Venture InvestmentsUnited StatesLos Angeles, CA2ParticipantMay 2016
Qatar Investment AuthorityQatarQatar2ParticipantSep 2018
Bering CapitalUnited StatesSan Francisco, CA2ParticipantMar 2021
Rice UniversityUnited StatesHouston, TX2ParticipantMay 2016
GreatPoint VenturesUnited StatesNew Haven, CT1LeadOct 2016
Takeda VenturesUnited StatesSan Diego, CA1ParticipantMay 2023
The University of Texas M.D. Anderson Cancer CenterUnited StatesHouston, TX1ParticipantMay 2016
Yonjin VentureUnited StatesUnited States1ParticipantMar 2021

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Acquisitions by OncoResponse

OncoResponse has acquired 1 company to date.

Last acquisition by OncoResponse was on November 7th 2017. OncoResponse acquired Paganini Biopharma for undisclosed valuation.


Latest Acquisitions by OncoResponse

Paganini Biopharma
Description
Paganini Biopharma is a Vancouver-based biotechnology firm developing therapeutics for cancer and infectious diseases. Its lead candidate is a human monoclonal antibody targeting breast cancer stem cells for triple-negative breast cancer treatment. The company advances candidates through preclinical stages with partnerships in monoclonal antibody production.
HQ CountryUnited States
HQ City
Los Angeles, CA
Deal Date7 Nov 2017
Valuationundisclosed
EV/Revenue
EV/EBITDA

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OncoResponse Competitors

OncoResponse competitors include listed companies like SynAct Pharma, Semnur Pharmaceuticals, Pure Biologics and Citius Oncology, and private ones like iVIEW Therapeutics and Aminex Therapeutics.

Public and private companies comparable to OncoResponse
CompanyHQStatusRevenueEBITDAValuationRevenue Multiple
SynAct PharmaSwedenSwedenPublicly listed-($12M)$106M-
Semnur PharmaceuticalsUnited StatesUnited StatesPublicly listed-($160M)$106M-
Pure BiologicsPolandPolandPublicly listed-($1M)$106M-
Citius OncologyUnited StatesUnited StatesPublicly listed-($24M)$106M7.4x
iVIEW TherapeuticsUnited StatesPhiladelphia, PAPrivate--$107M-
Aminex TherapeuticsUnited StatesSeattle, WAPrivate--$105M-

OncoResponse Public Comps

OncoResponse is still privately-owned, but its public comps include SynAct Pharma, Semnur Pharmaceuticals, Pure Biologics, Citius Oncology, Eurofins-Cerep, Polaryx Therapeutics, Guerbet, Dimerix, Cumberland and BGM Group.

Last FYEV/RevenueEV/EBITDA
RevenueEBITDALast FYLTM2027ELast FYLTM2027E
SynAct Pharma-($12M)--(8.7x)(14.6x)
Semnur Pharmaceuticals-($160M)--(0.8x)-
Pure Biologics-($1M)--(76.0x)-
Citius Oncology-($24M)-7.4x(4.2x)-
Eurofins-Cerep$47M$7M1.7x-11.8x-
Polaryx Therapeutics-($9M)--(10.6x)-
Guerbet$920M($34M)0.5x0.5x(13.1x)5.5x
Dimerix$3M($25M)30.2x24.2x(3.7x)(4.1x)

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Common questions about OncoResponse

When was OncoResponse founded?OncoResponse was founded in 2016.
Where is OncoResponse headquartered?OncoResponse is headquartered in Seattle, WA, United States.
Is OncoResponse publicly listed?No, OncoResponse is a private, VC-backed company.
What is OncoResponse's valuation?OncoResponse was last valued at $106M in its Series B in September 2018.
How much funding has OncoResponse raised?OncoResponse has raised $117M across 6 funding rounds.
What was OncoResponse's last funding round?OncoResponse's last funding round was a $14M Series D in May 2023, led by RiverVest.
Who are OncoResponse's investors?OncoResponse's investors include Canaan Partners, 3B Future Health Fund, ARCH Venture Partners, RiverVest, Redmile Group, Alexandria Venture Investments, Qatar Investment Authority, Bering Capital, Rice University, GreatPoint Ventures and 7 others.
Which companies are comparable to OncoResponse?Companies comparable to OncoResponse include SynAct Pharma, Semnur Pharmaceuticals, Pure Biologics, Citius Oncology, iVIEW Therapeutics and Aminex Therapeutics.
How many companies has OncoResponse acquired?OncoResponse has acquired 1 company, including Paganini Biopharma.

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