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- Dewpoint Therapeutics
Dewpoint Therapeutics Valuation, Funding & Investors
Dewpoint Therapeutics is valued at $504M as of September 2025.
Last Dewpoint Therapeutics valuation
$504M
Series D · Sep 2025
Last Dewpoint Therapeutics funding round
$59M
Series D · Sep 2025
Cumulative funding Dewpoint Therapeutics raised
$346M
across 4 funding rounds
Key investors in Dewpoint Therapeutics
Polaris Partners
Samsara BioCapital
Leaps by Bayer
EcoR1 Capital
ARCH Venture Partners
Maverick Ventures
About Dewpoint Therapeutics
Dewpoint Therapeutics is a Boston, Massachusetts-headquartered biotechnology company founded in 2018 modulating biomolecular condensates for diseases like ALS and cancer. The Condensate Dialysis platform screens compounds disrupting pathological condensates using AI-driven imaging, with lead candidates targeting FUS protein aggregates entering Phase 1 trials in 2023.
Founded
2018
HQ
Website
Status
Privately held
Customer focus
B2B
Revenue model
Product sales
Valuation
$504M (Sep 2025)
Dewpoint Therapeutics Valuation
Dewpoint Therapeutics is currently valued at $504M, based on its Series D in September 2025.
Dewpoint Therapeutics valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Sep 2025 | Series D | $504M |
Dewpoint Therapeutics Funding History
Dewpoint Therapeutics has raised a total of $346M across 4 funding rounds.
Dewpoint Therapeutics' first fundraising round was a $60M Series A in January 2019. The most recent completed round was a $59M Series D in September 2025.
Dewpoint Therapeutics funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Sep 2025 | Series D | - | $59M | $504M | Dewpoint Therapeutics is a biotechnology company pioneering condensate biology to develop first-in-class condensate modulators (c-mods) for difficult-to-treat diseases across oncology, neurodegenerative, cardiopulmonary, and metabolic areas. Its proprietary AI/ML-powered platform supports a broad drug discovery pipeline, with key programs like DPTX3186 targeting gastric cancer by disrupting oncogenic Wnt signaling via β-catenin condensates, and another targeting the undruggable MYC protein. The company maintains strategic collaborations with Bayer, Novo Nordisk, and Mitsubishi Tanabe Pharma to advance condensate-based medicines. Prior fundings include a $150 million Series C in February 2022 led by SoftBank Vision Fund 2, bringing total raised to approximately $346 million over five rounds. The round provides operational runway into early 2027, funding the initiation of clinical trials for DPTX3186 by year-end 2025, aiming for early proof-of-concept by end-2026, and accelerating MYC-targeted c-mod development. Dewpoint has faced challenges, including reported losses of alliances with Merck and Pfizer, and staff layoffs, but continues to progress clinically with orphan drug designation for DPTX3186 and partnerships like the up-to-$480 million ALS deal with Mitsubishi Tanabe. |
| Feb 2022 | Series C | SoftBank Group (lead); General Catalyst; Polaris Partners; Leaps by Bayer; Maverick Ventures; 3E Bioventures; Mubadala; Samsara BioCapital; EcoR1 Capital; Mirae Asset Capital; NS Investment; ARCH Venture Partners | $150M | - | Dewpoint Therapeutics, a biomolecular condensates company focused on drug discovery, completed a $150 million Series C financing on February 3, 2022, led by SoftBank Vision Fund 2, with new investors including General Catalyst, Mubadala Capital Ventures, 3E Bioventures Capital, Mirae Asset Capital, and NS Investment, alongside existing investors Leaps by Bayer, Polaris Partners, Samsara BioCapital, ARCH Venture Partners, EcoR1 Capital, and Maverick Ventures. The proceeds are designated to advance multiple pipeline programs through IND-enabling studies, invest in the company's fully integrated multi-component biology platform and AI-driven data science platform, and expand research infrastructure to support over 20 discovery and development programs across oncology, neuromuscular, cardiopulmonary, and virology indications. The financing underscores investor confidence in Dewpoint's leadership in biomolecular condensates, an emerging field for addressing diseases through condensate dysregulation, with CEO Ameet Nathwani highlighting the syndicate's support for breakthrough medicines and SoftBank's Vikas Parekh praising the team's experience and pharmaceutical partnerships. Dewpoint maintains collaborations such as a Pfizer deal valued at up to $239 million for myotonic dystrophy type 1 treatments, reflecting strategic alliances in rare genetic disorders. |
| Sep 2020 | Series B | ARCH Venture Partners (lead); Bellco Capital; Polaris Partners; Innovation Endeavors; Leaps by Bayer; Maverick Ventures; Samsara BioCapital; EcoR1 Capital | $77M | - | Dewpoint Therapeutics, a biotechnology company pioneering drugs targeting biomolecular condensates—non-membrane-bound cellular structures driving disease through protein interactions—raised $77 million in an oversubscribed Series B financing on September 29, 2020. ARCH Venture Partners led the round, with participation from new investors Maverick Ventures and Bellco Capital, alongside existing backers Leaps by Bayer, EcoR1 Capital, Polaris Partners, Samsara BioCapital, and Innovation Endeavors. The funds supported platform development to identify compounds modulating condensates and expansion into oncology, neurodegeneration, metabolic disease, and immunology. Prior to the Series B, Dewpoint launched in January 2019 with a $60 million Series A led by Polaris Partners, joined by Samsara BioCapital, 6 Dimensions Capital, EcoR1 Capital, Alexandria Venture Investments, and Leaps by Bayer. By mid-2020, the company had secured major collaborations: an exclusive deal with Merck in July 2020 for HIV treatments using its condensate platform, and a November 2019 partnership with Bayer leveraging its small molecule library for cardiovascular and gynecological diseases. Subsequent financings included a $150 million Series C in February 2022 led by SoftBank Vision Fund 2, with General Catalyst, Mubadala Capital, 3E Bioventures Capital, Mirae Asset Capital, and NS Investment as new investors, plus prior backers; proceeds advanced pipeline programs in oncology, neuromuscular, cardiopulmonary, and virology to IND stage while enhancing AI-driven data platforms. Later rounds totaled over $287 million across four, per aggregated reports, with a Series D grant noted in 2025. |
| Jan 2019 | Series A | Polaris Partners (lead); Alexandria Venture Investments; Leaps by Bayer; Samsara BioCapital; EcoR1 Capital; 6 Dimensions Capital | $60M | - | Dewpoint Therapeutics launched on January 30, 2019, with a $60 million Series A financing round led by founding investor Polaris Partners, joined by Samsara BioCapital, 6 Dimensions Capital, EcoR1 Capital, Alexandria Venture Investments, and Leaps by Bayer. The Cambridge, Massachusetts-based company focuses on drug discovery targeting biomolecular condensates, membraneless organelles that concentrate proteins and nucleic acids to drive cellular chemical reactions, an understudied area due to challenges with traditional methods like protein crystallography. This approach builds on research by founders Anthony Hyman from the Max Planck Institute of Molecular Cell Biology and Genetics and Richard Young from the Whitehead Institute. The financing supports Dewpoint's efforts to industrialize drugging condensates, with teams in Cambridge and Dresden, Germany, and a scientific advisory board including MIT professor Bob Langer. The company aims to address diseases involving condensate dysregulation, such as cancer, cardiovascular conditions, immunology, neurodegenerative disorders, virology, and women's health. Amir Nashat, managing partner at Polaris Partners, served as CEO at launch. Subsequent rounds include a $77 million Series B in September 2020 led by ARCH Venture Partners and a $150 million Series C in February 2022 led by SoftBank Vision Fund 2. |
Who has invested in Dewpoint Therapeutics?
16 investors have backed Dewpoint Therapeutics across its funding rounds, including Polaris Partners, Samsara BioCapital, Leaps by Bayer, EcoR1 Capital, ARCH Venture Partners and Maverick Ventures.
Lead investors include SoftBank Group, ARCH Venture Partners and Polaris Partners.
Dewpoint Therapeutics Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 3 | Lead | Jan 2019 | ||
| 3 | Participant | Jan 2019 | ||
| 3 | Participant | Jan 2019 | ||
| 3 | Participant | Jan 2019 | ||
| 2 | Participant | Sep 2020 | ||
| 2 | Lead | Sep 2020 | ||
| 1 | Participant | Feb 2022 | ||
| 1 | Participant | Sep 2020 | ||
| 1 | Lead | Feb 2022 | ||
| 1 | Participant | Jan 2019 | ||
| 1 | Participant | Sep 2020 | ||
| 1 | Participant | Feb 2022 | ||
| 1 | Participant | Feb 2022 | ||
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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
Sign up to see data on 350K+ funding rounds and disclosed revenue and EBITDA valuation multiples, from seed, through growth stage, to pre-IPO.
Start Free TrialDewpoint Therapeutics Competitors
Dewpoint Therapeutics competitors include listed companies like Avacta Group, Eikon Therapeutics and OmniAb, and private ones like Immvira, Biocytogen and Angiocrine Bioscience.
| Company | HQ | Status | Revenue | EBITDA | Valuation | Revenue Multiple |
|---|---|---|---|---|---|---|
| Private | - | - | $500M | - | ||
| Publicly listed | $152K | ($38M) | $495M | 184.3x | ||
| Publicly listed | - | ($315M) | $465M | - | ||
| Private | - | - | $425M | - | ||
| Publicly listed | $19M | ($47M) | $646M | 20.2x | ||
| Private | - | - | $697M | - |
Dewpoint Therapeutics Public Comps
Dewpoint Therapeutics is still privately-owned, but its public comps include Pharmicell, Ever Supreme Bio Technology, Vogenx, Kamada, Boiron, Onconic Therapeutics, Contineum Therapeutics, Autolus Therapeutics, Avacta Group and Assembly Biosciences.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| $83M | $27M | 5.7x | 6.2x | 17.6x | 18.6x | |||
| $32M | $16M | 14.9x | 14.6x | 29.1x | - | |||
| - | ($1M) | - | - | (349.7x) | - | |||
| $180M | $37M | 2.5x | 2.3x | 11.9x | 9.2x | |||
| $577M | $83M | 0.8x | - | 5.3x | - | |||
| $39M | $9M | 11.7x | - | 48.5x | - | |||
| - | ($68M) | - | 74.7x | (3.9x) | (3.7x) | |||
| $75M | ($258M) | 5.2x | 3.1x | (1.5x) | (1.8x) | |||
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Common questions about Dewpoint Therapeutics
| When was Dewpoint Therapeutics founded? | Dewpoint Therapeutics was founded in 2018. |
| Where is Dewpoint Therapeutics headquartered? | Dewpoint Therapeutics is headquartered in Boston, MA, United States. |
| Is Dewpoint Therapeutics publicly listed? | No, Dewpoint Therapeutics is a private, VC-backed company. |
| What is Dewpoint Therapeutics' valuation? | Dewpoint Therapeutics was last valued at $504M in its Series D in September 2025. |
| How much funding has Dewpoint Therapeutics raised? | Dewpoint Therapeutics has raised $346M across 4 funding rounds. |
| What was Dewpoint Therapeutics' last funding round? | Dewpoint Therapeutics' last funding round was a $59M Series D in September 2025. |
| Who are Dewpoint Therapeutics' investors? | Dewpoint Therapeutics' investors include Polaris Partners, Leaps by Bayer, Samsara BioCapital, EcoR1 Capital, Maverick Ventures, ARCH Venture Partners, General Catalyst, Bellco Capital, SoftBank Group, Alexandria Venture Investments and 6 others. |
| Which companies are comparable to Dewpoint Therapeutics? | Companies comparable to Dewpoint Therapeutics include Immvira, Avacta Group, Eikon Therapeutics, Biocytogen, OmniAb and Angiocrine Bioscience. |
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