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- Arbor Biotechnologies
Arbor Biotechnologies Valuation, Funding & Investors
Arbor Biotechnologies is valued at $42M as of June 2017.
Last Arbor Biotechnologies valuation
$42M
Series A · Jun 2017
Last Arbor Biotechnologies funding round
$74M
Series C · Mar 2025
Cumulative funding Arbor Biotechnologies raised
$305M
across 3 funding rounds
Key investors in Arbor Biotechnologies
ARCH Venture Partners
TCG Crossover
Temasek
Alexandria Venture Investments
Ally Bridge Group
About Arbor Biotechnologies
Arbor Biotechnologies is a Boston-based biotechnology firm that engineers novel gene-editing enzymes for therapeutic applications in genetic diseases. The company employs artificial intelligence and high-throughput screening platforms to discover programmable editing systems beyond CRISPR-Cas9, targeting conditions like sickle cell disease and muscular dystrophy. Its TIGR-TnY system enables precise insertions into human genomes without double-strand breaks. Founded in 2016, Arbor partners with academic institutions and holds patents on RNA-guided integrases, advancing clinical candidates through its Cambridge, Massachusetts facilities.
Founded
2016
HQ
Website
Status
Privately held
Customer focus
B2B
Revenue model
Licensing
Valuation
$42M (Jun 2017)
Sectors
Arbor Biotechnologies Valuation
Arbor Biotechnologies is currently valued at $42M, based on its Series A in June 2017.
The $16M round included Alexandria Venture Investments and ARCH Venture Partners.
Arbor Biotechnologies valuation by funding round
| Date | Stage | Valuation |
|---|---|---|
| Jun 2017 | Series A | $42M |
Arbor Biotechnologies Funding History
Arbor Biotechnologies has raised a total of $305M across 3 funding rounds.
Arbor Biotechnologies' first fundraising round was a $16M Series A in June 2017. The most recent completed round was a $74M Series C in March 2025.
Arbor Biotechnologies funding rounds
| Date | Stage | Investors | Raised | Valuation | Deal Summary |
|---|---|---|---|---|---|
| Mar 2025 | Series C | ARCH Venture Partners (lead); TCG Crossover (lead) | $74M | - | Arbor Biotechnologies announced a $73.9 million Series C financing on March 18, 2025, led by ARCH Venture Partners and TCGX. The company is a gene-editing therapeutics developer focused on CRISPR-based genetic medicines for liver and central nervous system diseases. The financing extends Arbor's cash runway into 2027 and includes participation from new investors QIA, Partners Investment, Revelation Partners, and Kerna Ventures, alongside existing investors including Temasek, Ally Bridge Group, T. Rowe Price Associates, Vertex Pharmaceuticals, and others. The company's proprietary platform leverages machine learning and AI to access a database of billions of proteins, enabling development of wholly-owned CRISPR genomic editors with first-in-class potential. Arbor's lead program, ABO-101, targets primary hyperoxaluria type 1 and has received orphan drug designation and rare pediatric disease designation from the FDA, with a Phase 1/2 clinical trial listed. The proceeds will support clinical development of ABO-101 and advancement of additional programs including a reverse transcriptase-based editing program for a rare liver disease and a program targeting amyotrophic lateral sclerosis. The company has demonstrated capital-efficient execution with strong preclinical data across its pipeline. |
| Nov 2021 | Series B | Ally Bridge Group (lead); TCG Crossover (lead); Temasek (lead) | $215M | - | Arbor Biotechnologies, a Cambridge, MA-based biotechnology company co-founded by David Walt, Ph.D., and Feng Zhang, Ph.D., develops next-generation genetic medicines using a proprietary discovery engine that applies machine learning and AI to a protein database containing billions of proteins, creating the most extensive toolbox of wholly owned CRISPR genomic editors in the industry. The company focuses on precision editing therapeutics for serious genetic diseases, with lead programs targeting liver and CNS conditions, including primary hyperoxaluria, and maintains a collaboration with Vertex Pharmaceuticals on cell therapies for Type 1 diabetes, sickle cell disease, and beta thalassemia via a $1.2 billion biobucks deal adjusted three months prior. On November 9, 2021, Arbor announced the closing of an oversubscribed, up-sized $215 million Series B financing round, bringing total funding to over $300 million. The round was co-led by Temasek, Ally Bridge Group, and TCG Crossover, with participation from new investors including Arrowmark Partners, Deep Track Capital, Great Point Ventures, Illumina Ventures, Janus Henderson Investors, Logos Capital, Ono Venture Investment, Piper Heartland Healthcare Capital, Ridgeback Capital Investments, Section 32, Surveyor Capital (a Citadel company), T. Rowe Price Associates, Tao Capital Partners, and Tekla Capital Management, alongside existing investor Arch Venture Partners and strategic partner Vertex Pharmaceuticals. Chen Yu, Managing Partner at TCG Crossover, joined the board as part of the financing. Proceeds from the Series B are allocated to advance lead programs in liver and CNS diseases into the clinic, progress a pipeline of precision editing therapeutics, and invest further in the novel discovery engine for next-generation gene editing technology. CEO Devyn Smith, Ph.D., highlighted the support from top investors and Vertex to realize curative genetic medicines, while Ally Bridge Group CEO Frank Yu emphasized the platform's potential for novel gene editing approaches and therapies. |
| Jun 2017 | Series A | Alexandria Venture Investments; ARCH Venture Partners | $16M | $42M | Arbor Biotechnologies emerged from stealth in 2017 with a Series A funding round totaling $15.6 million, including an initial $12.2 million raised in June 2016 and the remainder in August 2017. Investors included ARCH Venture Partners, Faridan Ventures, and Alexandria Real Estate Equities. The company, founded in mid-2016, focuses on developing new CRISPR-associated enzymes, starting with the Cas13d discovery, as part of its gene editing platform. The founding team includes David Walt from Harvard and the Wyss Institute. Arbor has since advanced through multiple funding rounds, including a $215 million oversubscribed Series B in November 2021 and later Series C extensions, building a pipeline of precision gene editing therapeutics for liver and CNS diseases. |
Who has invested in Arbor Biotechnologies?
5 investors have backed Arbor Biotechnologies across its funding rounds, including ARCH Venture Partners, TCG Crossover, Temasek, Alexandria Venture Investments and Ally Bridge Group.
Lead investors include ARCH Venture Partners, TCG Crossover, Ally Bridge Group and Temasek.
Arbor Biotechnologies Investors
| Investor | HQ | Rounds | Role | First check |
|---|---|---|---|---|
| 2 | Lead | Nov 2021 | ||
| 2 | Lead | Jun 2017 | ||
| 1 | Lead | Nov 2021 | ||
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Benchmark 350K+ Funding Rounds and Disclosed VC Valuation Multiples
Sign up to see data on 350K+ funding rounds and disclosed revenue and EBITDA valuation multiples, from seed, through growth stage, to pre-IPO.
Start Free TrialAcquisitions by Arbor Biotechnologies
Arbor Biotechnologies has acquired 1 company to date.
Last acquisition by Arbor Biotechnologies was on May 8th 2024. Arbor Biotechnologies acquired Serendipity Biosciences for undisclosed valuation.
Latest Acquisitions by Arbor Biotechnologies
| Description | Serendipity Biosciences is a UK-based biotechnology company developing novel gene editing tools beyond CRISPR. Focused on therapeutic applications for genetic diseases, it leverages proprietary nucleases discovered through high-throughput screening, with preclinical programs in liver and muscle disorders. |
| HQ Country | |
| HQ City | - |
| Deal Date | 8 May 2024 |
| Valuation | undisclosed |
| EV/Revenue | |
| EV/EBITDA | |
This data is available for Pro users. Sign up to see all Arbor Biotechnologies acquisitions and their M&A valuation multiples. Start Free Trial | |
Arbor Biotechnologies Competitors
Arbor Biotechnologies competitors include listed companies like Herantis Pharma, Seres Therapeutics, Mendus and Incannex, and private ones like TearSolutions and CorriXR Therapeutics.
| Company | HQ | Status | Revenue | EBITDA | Valuation | Revenue Multiple |
|---|---|---|---|---|---|---|
| Private | - | - | $42M | - | ||
| Publicly listed | - | ($8M) | $42M | - | ||
| Publicly listed | $789K | ($62M) | $41M | 8.2x | ||
| Publicly listed | - | ($11M) | $41M | 45.5x | ||
| Publicly listed | $86K | ($46M) | $43M | - | ||
| Private | - | - | $43M | - |
Arbor Biotechnologies Public Comps
Arbor Biotechnologies is still privately-owned, but its public comps include Herantis Pharma, Seres Therapeutics, Mendus, Incannex, Veru, Neurothera Labs, Karyopharm Therapeutics, Corline Biomedical, Synthaverse and Prism Biolab.
| Last FY | EV/Revenue | EV/EBITDA | ||||||
|---|---|---|---|---|---|---|---|---|
| Revenue | EBITDA | Last FY | LTM | 2027E | Last FY | LTM | 2027E | |
| - | ($8M) | - | - | (5.0x) | (5.6x) | |||
| $789K | ($62M) | 104.4x | 8.2x | (1.3x) | - | |||
| - | ($11M) | - | 45.5x | (3.3x) | (3.5x) | |||
| $86K | ($46M) | - | - | - | - | |||
| - | ($16M) | - | - | (1.1x) | - | |||
| $856K | ($4M) | 55.7x | - | (11.7x) | - | |||
| $146M | ($153M) | 1.6x | 1.7x | (1.5x) | - | |||
| $780K | ($1M) | 47.3x | 15.1x | (24.7x) | (80.2x) | |||
This data is available for Pro users. Sign up to see all Arbor Biotechnologies competitors and their valuation data. Start Free Trial | ||||||||
Common questions about Arbor Biotechnologies
| When was Arbor Biotechnologies founded? | Arbor Biotechnologies was founded in 2016. |
| Where is Arbor Biotechnologies headquartered? | Arbor Biotechnologies is headquartered in United States. |
| Is Arbor Biotechnologies publicly listed? | No, Arbor Biotechnologies is a private, VC-backed company. |
| What is Arbor Biotechnologies' valuation? | Arbor Biotechnologies was last valued at $42M in its Series A in June 2017. |
| How much funding has Arbor Biotechnologies raised? | Arbor Biotechnologies has raised $305M across 3 funding rounds. |
| What was Arbor Biotechnologies' last funding round? | Arbor Biotechnologies' last funding round was a $74M Series C in March 2025, led by ARCH Venture Partners and TCG Crossover. |
| Who are Arbor Biotechnologies' investors? | Arbor Biotechnologies' investors include TCG Crossover, ARCH Venture Partners, Temasek, Alexandria Venture Investments and Ally Bridge Group. |
| Which companies are comparable to Arbor Biotechnologies? | Companies comparable to Arbor Biotechnologies include TearSolutions, Herantis Pharma, Seres Therapeutics, Mendus, Incannex and CorriXR Therapeutics. |
| How many companies has Arbor Biotechnologies acquired? | Arbor Biotechnologies has acquired 1 company, including Serendipity Biosciences. |
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